ChemInform Abstract: FURANS AS INTERMEDIATES FOR THE SYNTHESIS OF OXYGENATED NATURAL PRODUCTS. ASYMMETRIC SYNTHESIS OF PRELOG-DJERASSI LACTONE

1985 ◽  
Vol 16 (14) ◽  
Author(s):  
S. F. MARTIN ◽  
D. E. GUINN
Keyword(s):  
Natural Products ◽  
Asymmetric Synthesis

ChemInform Abstract: Organocatalytic Asymmetric Synthesis of Chiral Nitrogenous Heterocycles and Natural Products

ChemInform ◽  
2015 ◽  
Vol 46 (7) ◽  
pp. no-no
Author(s):  
Jie Yu ◽  
Ya Zhou ◽  
Dian-Feng Chen ◽  
Liu-Zhu Gong
Keyword(s):  
Natural Products ◽  
Asymmetric Synthesis

scholarly journals Heronapyrrole D: A case of co-inspiration of natural product biosynthesis, total synthesis and biodiscovery

2014 ◽  
Vol 10 ◽  
pp. 1228-1232 ◽  
Author(s):  
Jens Schmidt ◽  
Zeinab Khalil ◽  
Robert J Capon ◽  
Christian B W Stark
Keyword(s):  
Antibacterial Activity ◽  
Natural Products ◽  
Total Synthesis ◽  
Asymmetric Synthesis ◽  
Natural Product ◽  
Joint Effort ◽  
Natural Product Biosynthesis ◽  
New Members ◽  
Degree Of Oxidation ◽  
Rare Class

The heronapyrroles A–C have first been isolated from a marine-derived Streptomyces sp. (CMB-0423) in 2010. Structurally, these natural products feature an unusual nitropyrrole system to which a partially oxidized farnesyl chain is attached. The varying degree of oxidation of the sesquiterpenyl subunit in heronapyrroles A–C provoked the hypothesis that there might exist other hitherto unidentified metabolites. On biosynthetic grounds a mono-tetrahydrofuran-diol named heronapyrrole D appeared a possible candidate. We here describe a short asymmetric synthesis of heronapyrrole D, its detection in cultivations of CMB-0423 and finally the evaluation of its antibacterial activity. We thus demonstrate that biosynthetic considerations and the joint effort of synthetic and natural product chemists can result in the identification of new members of a rare class of natural products.

scholarly journals Asymmetric Synthesis and Cytotoxicity Evaluation of Right-Half Models of Antitumor Renieramycin Marine Natural Products

Marine Drugs ◽  
2018 ◽  
Vol 17 (1) ◽  
pp. 3 ◽  
Author(s):  
Takehiro Matsubara ◽  
Masashi Yokoya ◽  
Natchanun Sirimangkalakitti ◽  
Naoki Saito
Keyword(s):  
Prostate Cancer ◽  
Colorectal Cancer ◽  
Natural Products ◽  
Asymmetric Synthesis ◽  
Active Compound ◽  
Hct116 Cell ◽  
Human Prostate Cancer ◽  
Model Compounds ◽  
Structure Activity ◽  
Sar Study

A general protocol for the asymmetric synthesis of 3-N-arylmethylated right-half model compounds of renieramycins was developed, which enabled structure–activity relationship (SAR) study of several 3-N-arylmethyl derivatives. The most active compound (6a) showed significant cytotoxic activity against human prostate cancer DU145 and colorectal cancer HCT116 cell lines (IC50 = 11.9, and 12.5 nM, respectively).

Asymmetric Synthesis of the Tricyclooctane Core of Trachylobane Natural Products and Related Terpenoids

2019 ◽  
Vol 21 (21) ◽  
pp. 8705-8707 ◽  
Author(s):  
Michael Schneider ◽  
Matthieu J. R. Richter ◽  
Simon Krautwald ◽  
Erick M. Carreira
Keyword(s):  
Natural Products ◽  
Asymmetric Synthesis

Catalytic asymmetric synthesis of natural products with heterocyclic rings

1998 ◽  
Vol 35 (5) ◽  
pp. 1057-1064 ◽  
Author(s):  
Masakatsu Shibasaki ◽  
Akihiko Kojima ◽  
Satoshi Shimizu
Keyword(s):  
Natural Products ◽  
Asymmetric Synthesis ◽  
Catalytic Asymmetric Synthesis ◽  
Catalytic Asymmetric

Organometallics-Based Catalytic (Asymmetric) Synthesis of Natural Products

2018 ◽  
pp. 191-259
Author(s):  
Hongbin Zhai ◽  
Yun Li ◽  
Bin Cheng ◽  
Zhiqiang Ma ◽  
Peng Gao ◽  
...  
Keyword(s):  
Natural Products ◽  
Asymmetric Synthesis ◽  
Catalytic Asymmetric Synthesis ◽  
Catalytic Asymmetric
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