ChemInform Abstract: ASYMMETRIC SYNTHESIS OF CYCLOPROPANECARBOXYLATES: CATALYSIS OF DIAZOACETATE REACTIONS BY COPPER(II) SCHIFF BASE COMPLEXES DERIVED FROM α-AMINO ACIDS

1984 ◽  
Vol 15 (52) ◽  
Author(s):  
D. A. LAIDLER ◽  
D. J. MILNER
Keyword(s):  
Amino Acids ◽  
Schiff Base ◽  
Asymmetric Synthesis ◽  
Schiff Base Complexes

General method for the asymmetric synthesis of α-amino acids via alkylation of the chiral nickel(II) Schiff base complexes of glycine and alanine

1988 ◽  
pp. 305-312 ◽  
Author(s):  
Yuri. N. Belokon ◽  
Vladimir I. Bakhmutov ◽  
Nina I. Chernoglazova ◽  
Konstantin A. Kochetkov ◽  
Sergei V. Vitt ◽  
...  
Keyword(s):  
Amino Acids ◽  
Schiff Base ◽  
Asymmetric Synthesis ◽  
Schiff Base Complexes ◽  
General Method

ChemInform Abstract: General Method for the Asymmetric Synthesis of α-Amino Acids via Alkylation of the Chiral Nickel(II) Schiff Base Complexes of Glycine and Alanine.

ChemInform ◽  
1988 ◽  
Vol 19 (19) ◽  
Author(s):  
YU. N. BELOKON' ◽  
V. I. BAKHMUTOV ◽  
N. I. CHERNOGLAZOVA ◽  
K. A. KOCHETKOV ◽  
S. V. VITT ◽  
...  
Keyword(s):  
Amino Acids ◽  
Schiff Base ◽  
Asymmetric Synthesis ◽  
Schiff Base Complexes ◽  
General Method

2-[18F]Fluorophenylalanine: Synthesis by Nucleophilic 18F-Fluorination and Preliminary Biological Evaluation

Synthesis ◽  
2019 ◽  
Vol 51 (03) ◽  
pp. 664-676 ◽  
Author(s):  
Bernd Neumaier ◽  
Daniel Modemann ◽  
Boris Zlatopolskiy ◽  
Elizaveta Urusova ◽  
Johannes Zischler ◽  
...  
Keyword(s):  
Amino Acids ◽  
Schiff Base ◽  
Biological Evaluation ◽  
Schiff Base Complexes ◽  
Biological Study ◽  
Automated Synthesis ◽  
Pet Tracer ◽  
Iodonium Salt ◽  
Acidic Conditions

2-[18F]Fluorophenylalanine (2-[18F]FPhe), a promising PET tracer for imaging of cerebral infarction and tumors, was efficiently prepared from an easily accessible iodonium salt precursor using Cu-mediated radiofluorination under ‘low base’ or ‘minimalist’ conditions. Whereas significant racemization was initially observed if the ‘minimalist’ protocol was applied for radiolabeling, it was completely suppressed by the careful adjustment of 18F– preprocessing. The initial biological study revealed a higher uptake of 2-[18F]FPhe in different tumor cells in comparison to that of [18F]FET. In contrast to 4-[18F]FPhe, which suffered from rapid defluorination in vivo, 2-[18F]FPhe demonstrated a sufficient in vivo stability. Conclusively, 2-[18F]FPhe is a promising PET probe that is now readily available using Cu-mediated radiofluorination under ‘minimalist’ or ‘low base’ conditions. The simplicity of the translation of the proposed procedures to automated synthesis modules allows a broad biological evaluation of 2-[18F]FPhe. Notably, a novel protocol for the preparation of N-Boc protected amino acids from the respective Ni-Schiff base complexes was developed that avoided application of strongly acidic conditions.

scholarly journals Synthesis, Spectroscopic, Molecular Structure, and Antibacterial Studies of Dibutyltin(IV) Schiff Base Complexes Derived from Phenylalanine, Isoleucine, and Glycine

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Har Lal Singh ◽  
Jangbhadur Singh
Keyword(s):  
Amino Acids ◽  
Schiff Base ◽  
Schiff Bases ◽  
Molar Conductance ◽  
Schiff Base Complexes ◽  
Spectral Studies ◽  
E Coli ◽  
Elemental Analyses ◽  
In Vitro Antibacterial Activity

New series of organotin(IV) complexes and Schiff bases derived from amino acids have been designed and synthesized from condensation of1H-indole-2,3-dione, 5-chloro-1H-indole-2,3-dione, andα-amino acids (phenylalanine, isoleucine, and glycine). All compounds are characterized by elemental analyses, molar conductance measurements, and molecular weight determinations. Bonding of these complexes is discussed in terms of their UV-visible, infrared, and nuclear magnetic resonance (1H,13C, and119Sn NMR) spectral studies. The results suggest that Schiff bases behave as monobasic bidentate ligands and coordinate with dibutyltin(IV) in octahedral geometry according to the general formula [Bu2Sn(L)2]. Elemental analyses and NMR spectral data of the ligands with their dibutyltin(IV) complexes agree with their proposed distorted octahedral structures. Few representative compounds are tested for their in vitro antibacterial activity against Gram-positive (B. cereus,Staphylococcusspp.) and Gram-negative (E. coli,Klebsiellaspp.) bacteria. The results show that the dibutyltin complexes are more reactive with respect to their corresponding Schiff base ligands.

Preparation and characterisation of new oxovanadium(IV) Schiff base complexes derived from amino acids and aromatic o-hydroxyaldehydes

1999 ◽  
Vol 293 (1) ◽  
pp. 1-11 ◽  
Author(s):  
J.Costa Pessoa ◽  
I. Cavaco ◽  
I. Correia ◽  
M.T. Duarte ◽  
R.D. Gillard ◽  
...  
Keyword(s):  
Amino Acids ◽  
Schiff Base ◽  
Schiff Base Complexes
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