ChemInform Abstract: ANTIOXIDANT ACTIVITY OF PHENOLS RELATED TO VITAMIN E. ARE THERE CHAIN-BREAKING ANTIOXIDANTS BETTER THAN α-TOCOPHEROL?

1983 ◽  
Vol 14 (50) ◽  
Author(s):  
G. W. BURTON ◽  
L. HUGHES ◽  
K. U. INGOLD
Keyword(s):  
Antioxidant Activity ◽  
Vitamin E ◽  
Chain Breaking ◽  
Better Than

scholarly journals Synthesis, DFT Calculations, and In Vitro Antioxidant Study on Novel Carba-Analogs of Vitamin E

Antioxidants ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. 589 ◽  
Author(s):  
Aneta Baj ◽  
Jakub Cedrowski ◽  
Ewa Olchowik-Grabarek ◽  
Artur Ratkiewicz ◽  
Stanislaw Witkowski
Keyword(s):  
Antioxidant Activity ◽  
Electron Transfer ◽  
Vitamin E ◽  
Density Functional ◽  
Lone Pair ◽  
Hydrogen Atom Transfer ◽  
Hydroxyl Group ◽  
Styrene Oxidation ◽  
Chain Breaking

Vitamin E is the most active natural lipophilic antioxidant with a broad spectrum of biological activity. α-Tocopherol (α-T), the main representative of the vitamin E family, is a strong inhibitor of lipid peroxidation as a chain-breaking antioxidant. Antioxidant and antiradical properties of vitamin E result from the presence of a phenolic hydroxyl group at the C-6 position. Due to stereoelectronic effects in the dihydropyranyl ring, the dissociation enthalpy for phenolic O–H bond (BDEOH) is reduced. The high chain-breaking reactivity of α-T is mainly attributed to orbital overlapping of the 2p-type lone pair on the oxygen atom (O1) in para position to the phenolic group, and the aromatic π-electron system. The influence of the O1 atom on the antioxidant activity of vitamin E was estimated quantitatively. The all-rac-1-carba-α-tocopherol was synthesized for the first time. Along with model compounds, 1-carba-analog of Trolox and its methyl ester were screened for their in vitro antioxidant activity by inhibition of styrene oxidation, and for the radical-reducing properties by means of 2,2-diphenyl-1-picrylhydrazyl free radical (DPPH) scavenging assay. To study the antioxidant activity, density functional theory (DFT) was also applied. Reaction enthalpies related to HAT (hydrogen atom transfer), SET–PT (sequential electron transfer—proton transfer), and SPLET (sequential proton loss—electron transfer) mechanisms were calculated.

scholarly journals Effect of phytyl side chain of vitamin E on its antioxidant activity.

1985 ◽  
Vol 260 (4) ◽  
pp. 2191-2196
Author(s):  
E Niki ◽  
A Kawakami ◽  
M Saito ◽  
Y Yamamoto ◽  
J Tsuchiya ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Vitamin E ◽  
Side Chain

Influence of vitamin E on gastric mucosal antioxidant activity in chronic gastritis

1993 ◽  
Vol 2 (Supplement) ◽  
pp. 22 ◽  
Author(s):  
I Beno ◽  
L Koszeghyová ◽  
K Volkovová ◽  
M Staruchová
Keyword(s):  
Antioxidant Activity ◽  
Vitamin E ◽  
Chronic Gastritis

Antioxidant activity and metabolite profile of quercetin in vitamin-E-depleted rats

2008 ◽  
Vol 19 (7) ◽  
pp. 467-474 ◽  
Author(s):  
Clement K. Ameho ◽  
C.-Y. Oliver Chen ◽  
Donald Smith ◽  
Concepción Sánchez-Moreno ◽  
Paul E. Milbury ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Vitamin E ◽  
Metabolite Profile

The extraordinary antioxidant activity of vitamin E phosphate

2004 ◽  
Vol 1683 (1-3) ◽  
pp. 16-21 ◽  
Author(s):  
Bashir M Rezk ◽  
Guido R.M.M Haenen ◽  
Wim J.F van der Vijgh ◽  
Aalt Bast
Keyword(s):  
Antioxidant Activity ◽  
Vitamin E

scholarly journals Antioxidant Activity, Phenolic Profile, and Nephroprotective Potential of Anastatica hierochuntica Ethanolic and Aqueous Extracts against CCl4-Induced Nephrotoxicity in Rats

Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2973
Author(s):  
Tariq I. Almundarij ◽  
Yousef M. Alharbi ◽  
Hassan A. Abdel-Rahman ◽  
Hassan Barakat
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Therapeutic Agent ◽  
Kidney Tissue ◽  
Kidney Injury ◽  
Total Phenolic ◽  
Drug Induced ◽  
Total Carotenoids ◽  
Phenolic Profile ◽  
Better Than

Kaff-e-Maryam (Anastatica hierochuntica L.) is extensively used to treat a range of health problems, most notably to ease childbirth and alleviate reproductive system-related disorders. This study aimed to evaluate the effect of A. hierochuntica ethanolic (KEE), and aqueous (KAE) extracts on CCl4-induced oxidative stress and nephrotoxicity in rats using the biochemical markers for renal functions and antioxidant status as well as histopathological examinations of kidney tissue. A. hierochuntica contained 67.49 mg GAE g−1 of total phenolic compounds (TPC), 3.51 µg g−1 of total carotenoids (TC), and 49.78 and 17.45 mg QE g−1 of total flavonoids (TF) and total flavonols (TFL), respectively. It resulted in 128.71 µmol of TE g−1 of DPPH-RSA and 141.92 µmol of TE g−1 of ABTS-RSA. A. hierochuntica presented superior antioxidant activity by inhibiting linoleic acid radicals and chelating oxidation metals. The HPLC analysis resulted in 9 and 21 phenolic acids and 6 and 2 flavonoids in KEE and KAE with a predominance of sinapic and syringic acids, respectively. Intramuscular injection of vit. E + Se and oral administration of KEE, KAE, and KEE + KAE at 250 mg kg−1 body weight significantly restored serum creatinine, urea, K, total protein, and albumin levels. Additionally, they reduced malondialdehyde (MOD), restored reduced-glutathione (GSH), and enhanced superoxide dismutase (SOD) levels. KEE, KAE, and KEE + KAE protected the kidneys from CCl4-nephrotoxicity as they mainly attenuated induced oxidative stress. Total nephroprotection was about 83.27%, 97.62%, and 78.85% for KEE, KAE, and KEE + KAE, respectively. Both vit. E + Se and A. hierochuntica extracts attenuated the histopathological alteration in CCl4-treated rats. In conclusion, A. hierochuntica, especially KAE, has the potential capability to restore oxidative stability and improve kidney function after CCl4 acute kidney injury better than KEE. Therefore, A. hierochuntica has the potential to be a useful therapeutic agent in the treatment of drug-induced nephrotoxicity.

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