ChemInform Abstract: NUCLEOAMINO ACIDS AND NUCLEOPEPTIDES. IX. SOLID-PHASE SYNTHESIS OF OLIGONUCLEOPEPTIDES CONTAINING MONOTONIC UNITS FROM RESIDUES OF β-(URACILYL-N′)-α-ALANINE AND β-(ADENYLYL-N9)-α-ALANINE

1982 ◽  
Vol 13 (17) ◽  
Author(s):  
YU. A. SEMILETOV ◽  
G. P. MISHIN ◽  
YU. P. SHVACHKIN
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Nucleoamino Acids

scholarly journals Solid phase synthesis and RNA-binding activity of an arginine-containing nucleopeptide

RSC Advances ◽  
2016 ◽  
Vol 6 (17) ◽  
pp. 14140-14148 ◽  
Author(s):  
G. N. Roviello ◽  
C. Vicidomini ◽  
S. Di Gaetano ◽  
D. Capasso ◽  
D. Musumeci ◽  
...  
Keyword(s):  
Rna Binding ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Binding Activity ◽  
Synthesis And Characterization ◽  
Phase Synthesis ◽  
Nucleoamino Acids ◽  
Arginine Residues

Here we report the solid phase synthesis and characterization (LC-ESIMS, CD) of a cationic nucleobase-containing α-peptide, composed of both l-arginine residues and l-lysine-based nucleoamino acids sequentially present in the structure.

Synthesis and Screening of A DNA-Encoded Library of Non-Peptidic Macrocycles

2020 ◽  
Author(s):  
Eric Koesema ◽  
Animesh Roy ◽  
Nicholas G. Paciaroni ◽  
Thomas Kodadek
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Cell Permeability ◽  
Phase Synthesis ◽  
Protein Ligands ◽  
High Affinity ◽  
Scaffold Diversity

There is considerable interest in the development of libraries of non-peptidic macrocycles as a source of ligands for difficult targets. We report here the solid-phase synthesis of a DNA-encoded library of several hundred thousand thioether-linked macrocycles. The library was designed to be highly diverse with respect to backbone scaffold diversity and to minimize the number of amide N-H bonds, which compromise cell permeability. The utility of the library as a source of protein ligands is demonstrated through the isolation of compounds that bind streptavidin, a model target, with high affinity.

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