ChemInform Abstract: TOTAL SYNTHESIS OF (+)-THROMBOXANE B2 FROM D-GLUCOSE. A DETAILED ACCOUNT

1981 ◽  
Vol 12 (30) ◽  
Author(s):  
S. HANESSIAN ◽  
P. LAVALLEE
Keyword(s):  
Total Synthesis ◽  
Thromboxane B2 ◽  
Detailed Account

Total synthesis of (+)-thromboxane B2 from D-glucose. A detailed account

1981 ◽  
Vol 59 (5) ◽  
pp. 870-877 ◽  
Author(s):  
Stephen Hanessian ◽  
Pierre Lavallee
Keyword(s):  
Total Synthesis ◽  
Thromboxane B2 ◽  
Detailed Account ◽  
Target Compound ◽  
Type Symmetry

The total synthesis of thromboxane B2 from D-glucose is described, based on the recognition of hidden carbohydrate-type symmetry in the molecule. Methyl 2-deoxy-α-D-ribo-hexopyranoside was prepared from D-glucose and manipulated in such a way as to introduce C-branching at C-4 in a stereocontrolled manner. This crucial intermediate was then transformed into the target compound by adaptations of established methodology in the field.

A stereospecifie, total synthesis of thromboxane B2

1977 ◽  
Vol 55 (3) ◽  
pp. 562-565 ◽  
Author(s):  
Stephen Hanessian ◽  
Pierre Lavallee
Keyword(s):  
Total Synthesis ◽  
Thromboxane B2

A stereospecific, total synthesis of crystalline thromboxane B2 from D-glucose is described.

ChemInform Abstract: TOTAL SYNTHESIS OF THROMBOXANE B2

1976 ◽  
Vol 7 (48) ◽  
pp. no-no ◽  
Author(s):  
N. A. NELSON ◽  
R. W. JACKSON
Keyword(s):  
Total Synthesis ◽  
Thromboxane B2

Synthesis and biological evaluation of palmyrolide A macrocycles as sodium channel blockers towards neuroprotection

2016 ◽  
Vol 14 (36) ◽  
pp. 8457-8473 ◽  
Author(s):  
Satish Chandra Philkhana ◽  
Suneet Mehrotra ◽  
Thomas F. Murray ◽  
D. Srinivasa Reddy
Keyword(s):  
Total Synthesis ◽  
Sodium Channel ◽  
Biological Evaluation ◽  
Detailed Account ◽  
Channel Blockers ◽  
Sodium Channel Blockers ◽  
Channel Inhibition ◽  
Synthesis And Biological Evaluation

A detailed account on total synthesis, analogue synthesis, biological evaluation and SAR of palmyrolide A macrocycles towards sodium channel inhibition is reported.

Total synthesis of thromboxane B2 starting from (R,R)-tartaric acid as a chiral pool

1996 ◽  
Vol 37 (52) ◽  
pp. 9321-9324 ◽  
Author(s):  
Yukio Masaki ◽  
Kazuhiro Yoshizawa ◽  
Akichika Itoh
Keyword(s):  
Total Synthesis ◽  
Tartaric Acid ◽  
Thromboxane B2

A direct total synthesis of thromboxane B2 (±)

1977 ◽  
Vol 18 (9) ◽  
pp. 785-788 ◽  
Author(s):  
E.J. Corey ◽  
Masakatsu Shibasaki ◽  
Jochen Knolle ◽  
T. Sugahara
Keyword(s):  
Total Synthesis ◽  
Thromboxane B2

scholarly journals Biomimetic Cyclization of Geraniol Derivatives, a Useful Tool in the Total Synthesis of Bioactive Monocyclic Terpenoids

2011 ◽  
Vol 6 (4) ◽  
pp. 1934578X1100600
Author(s):  
Valentina Merlini ◽  
Marco Luparia ◽  
Alessio Porta ◽  
Giuseppe Zanoni ◽  
Giovanni Vidari
Keyword(s):  
Total Synthesis ◽  
Building Blocks ◽  
Detailed Account ◽  
Biomimetic Cyclization ◽  
Very High

This review is a detailed account of authors’ work in the field of biomimetic cyclization of geraniol-like dienes. The very high regio- and enantioselectivity achieved made these elegant reactions a viable tool for the synthesis of monocyclic building blocks used in the synthesis of valued terpenoids, like the precious aroma and perfume constituents’ ionones and irones.

scholarly journals Total Synthesis of Thromboxane B2 via a Key Bicyclic Enal Intermediate

2020 ◽  
Vol 22 (16) ◽  
pp. 6505-6509
Author(s):  
Changcheng Jing ◽  
Varinder K. Aggarwal
Keyword(s):  
Total Synthesis ◽  
Thromboxane B2
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