ChemInform Abstract: AMINO ACID COMPLEXES OF PLATINUM(IV). II. TRIMETHYLPLATINUM(IV) COMPLEXES OF α-SUBSTITUTED AMINO ACIDS - ALANINE, VALINE, PHENYLALANINE, AND α-AMINOISOBUTYRIC ACID

1979 ◽  
Vol 10 (15) ◽  
Author(s):  
T. G. APPLETON ◽  
J. R. HALL ◽  
T. G. JONES
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Aminoisobutyric Acid ◽  
Amino Acid Complexes

Circular dichroism spectra of amino acid complexes. II. Chelated amino acid complexes with the CoN5O chromophore

1970 ◽  
Vol 23 (9) ◽  
pp. 1735 ◽  
Author(s):  
CJ Hawkins ◽  
PJ Lawson
Keyword(s):  
Amino Acids ◽  
Circular Dichroism ◽  
Amino Acid ◽  
Visible Region ◽  
Optically Active ◽  
Circular Dichroism Spectra ◽  
Amino Acid Complexes ◽  
Similar Series ◽  
Cotton Effects ◽  
Circular Dichroïsm

The circular dichroism spectra of a series of optically active (α-aminocarboxylato)tetraamminecobalt(111) complexes have been measured in aqueous solution, and in the presence of salts of polarizable anions. The observed spectra in the visible region have been analysed to determine the signs of the Cotton effects of the three components of the 1A1g ↔ 1T1g cobalt(111) transition. For L-amino acids, the transition with A2g(D4h) parentage is negative, and the two transitions with Eg(D4h) parentage have opposite signs. Published circular dichroism spectra of complexes of the type [Co(en)2(L-am)]2+ were similarly interpreted in terms of a perturbed tetragonal chromophore, and it was shown that the vicinal effect of the L-amino acids imposed the same signs onto the component transitions as for the tetraammines and for a similar series of pentaamminecobalt(111) complexes.

scholarly journals Amino acid uptake in isolated chick embryo heart cells. Effect of insulin

1969 ◽  
Vol 114 (1) ◽  
pp. 97-105 ◽  
Author(s):  
G. G. Guidotti ◽  
Britta Lüneburg ◽  
A. F. Borghetti
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Chick Embryo ◽  
Isolated Heart ◽  
Cardiac Cells ◽  
Cell Permeability ◽  
Heart Cells ◽  
Acid Uptake ◽  
Aminoisobutyric Acid ◽  
Isolated Heart Cells

1. The preparation of cell suspensions by treatment of chick embryo hearts with collagenase at various stages of development is described. 2. Measurements of oxygen consumption, incorporation of labelled leucine into protein and accumulation of labelled α-aminoisobutyric acid against a concentration gradient indicated a long-lasting viability of the isolated heart cells in vitro; a satisfactory preservation of subcellular structures, including plasma membrane, was assessed by electron-microscopic examination. 3. The rate of α-aminoisobutyric acid accumulation by cardiac cells isolated from hearts at different stages of embryological development decreased with aging; insulin stimulated the intracellular accumulation of this amino acid analogue. 4. Insulin increased the uptake by isolated heart cells of several 14C-labelled naturally occurring amino acids; however, the fraction of amino acid taken up by the cells that was recovered free intracellularly, and therefore the concentration ratio (between intracellular water and medium), was enhanced by the hormone only with glycine, proline, serine, threonine, histidine and methionine. When isolated heart cells were incubated in the presence of a mixture of labelled amino acids, the addition of insulin increased the disappearance of radioactivity from the medium. 5. The general pattern of amino acid transport (in the absence and in the presence of insulin) in isolated cardiac cells was similar to that found in intact hearts, suggesting that the biological preparation described in this paper might be useful for studies of cell permeability and insulin action.

Corticosteroids and accumulation of C14-labeled amino acids and histamine by isolated rat diaphragm

1960 ◽  
Vol 199 (4) ◽  
pp. 715-718 ◽  
Author(s):  
Ira G. Wool
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Rat Diaphragm ◽  
Amino Acid Analogue ◽  
Rate Of Penetration ◽  
Aminoisobutyric Acid ◽  
Acid Analogue ◽  
Isolated Rat

The rate of penetration and the magnitude of accumulation of several utilized C14-amino acids, of the amino acid analogue, α-aminoisobutyric acid-1-C14, and of C14-histamine was measured in intact and cut isolated rat diaphragm. Adrenalectomy was without effect on the rate of entry of the amino acids or of histamine; cortisone administration (2 mg/day) depressed the accumulation of the utilized amino acids, of α-aminoisobutyric acid and of histamine.

Circular dichroism spectra of amino acid complexes. III. Copper(II) compounds

1970 ◽  
Vol 23 (11) ◽  
pp. 2237 ◽  
Author(s):  
CJ Hawkins ◽  
CL Wong
Keyword(s):  
Amino Acids ◽  
Circular Dichroism ◽  
Amino Acid ◽  
Sign Pattern ◽  
Circular Dichroism Spectra ◽  
Amino Acid Complexes ◽  
Rotational Strength ◽  
Conformational Effects ◽  
Cotton Effects ◽  
Circular Dichroïsm

The solution circular dichroism spectra of the 1 : 1 and 1 : 2 copper(II) complexes of a series of �-amino acids are reported for the region 12500-25000 cm-1. These spectra and spectra of the isolated 1 : 2 complexes dispersed in KBr disks have been interpreted as arising from three Cotton effects with a -,+,- sign pattern for the L configuration, except for the L-proline spectra, which were analysed in terms of a +,-,+ pattern. A tentative assignment is made for these Cotton effects, and the relative contributions of vicinal and conformational effects to the rotational strength are discussed.

Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating foldamers for efficient siRNA delivery

2019 ◽  
Vol 55 (54) ◽  
pp. 7792-7795 ◽  
Author(s):  
Takashi Misawa ◽  
Nobumichi Ohoka ◽  
Makoto Oba ◽  
Hiroko Yamashita ◽  
Masakazu Tanaka ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Sirna Delivery ◽  
Aminoisobutyric Acid ◽  
Cell Penetrating ◽  
The Common

We have designed and synthesized a set of cell-penetrating foldamers (CPFs), Blocks 1–8, composed of the common amino acids Leu, Arg, and Gly, as well as the helicogenic amino acid 2-aminoisobutyric acid.

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