ChemInform Abstract: CMT (CANCER MULTIPLE THERAPY) SELECTIN SYNTHESIS. PART 2. PREPARATION OF CYSTEAMINE S-GLUCURONIDE

1979 ◽  
Vol 10 (5) ◽  
Author(s):  
J. OEHLKA
Keyword(s):  
Cancer Multiple ◽  
Multiple Therapy

scholarly journals Synergistic Tumor Therapy: Porous Gold Nanoshells on Functional NH2 -MOFs: Facile Synthesis and Designable Platforms for Cancer Multiple Therapy (Small 35/2018)

Small ◽  
2018 ◽  
Vol 14 (35) ◽  
pp. 1870157 ◽  
Author(s):  
Chuang Liu ◽  
Lijia Luo ◽  
Leyong Zeng ◽  
Jie Xing ◽  
Yuanzhi Xia ◽  
...  
Keyword(s):  
Tumor Therapy ◽  
Gold Nanoshells ◽  
Facile Synthesis ◽  
Porous Gold ◽  
Cancer Multiple ◽  
Multiple Therapy

Porous Gold Nanoshells on Functional NH2-MOFs: Facile Synthesis and Designable Platforms for Cancer Multiple Therapy

Small ◽  
2018 ◽  
Vol 14 (35) ◽  
pp. 1801851 ◽  
Author(s):  
Chuang Liu ◽  
Lijia Luo ◽  
Leyong Zeng ◽  
Jie Xing ◽  
Yuanzhi Xia ◽  
...  
Keyword(s):  
Gold Nanoshells ◽  
Facile Synthesis ◽  
Porous Gold ◽  
Cancer Multiple ◽  
Multiple Therapy

A Brief Review on Dual Target of PARP1 and STAT3 for Cancer Therapy: A Novel Perception

2020 ◽  
Vol 16 (2) ◽  
pp. 115-134
Author(s):  
Kaviarasan Lakshmanan ◽  
Gowramma Byran ◽  
Manal Mohammed
Keyword(s):  
Signaling Pathways ◽  
Single Molecule ◽  
Treatment Options ◽  
Poor Response ◽  
Cytotoxic Agents ◽  
Acquired Drug Resistance ◽  
Single Target ◽  
New Strategy ◽  
Cancer Multiple ◽  
Almost All

Background: Cancer is a disease characterized by the uncontrolled growth and spread of abnormal cells. Around the world, over 10 million cancer cases occur annually. Half of all men and one-third of all women will develop some form of cancer during their lifetime. It is one of the most feared diseases, primarily because half of those diagnosed with cancer die from it. There are several treatments available for cancer. Almost all traditional cytotoxic agents suffer from severe toxicities and other undesirable side effects. Objective: In recent years, the development of targeted medicines has made significant achievements. Unfortunately, though these agents can block key regulators of signaling pathways in cancer, multiple compensatory pathways always attenuate pharmacological effect of single-target drugs. In addition, poor response rates and acquired drug resistance also represent a significant barrier to widespread use of targeted medicines. More recently, a number of combinatorial therapies have expanded treatment options, which can directly block several key signaling pathways and create a synergistic effect. Conclusion: Therefore, in order to overcome these barriers, the present investigation aims to develop a new strategy for designing a single molecule with inhibition of two receptors (PARP1 and STAT3) simultaneously and producing enhanced anti-cancer activity with less and/or null toxicity.

scholarly journals The role of heterocyclic aromatic amines in colorectal cancer: the evidence from epidemiologic studies

2021 ◽  
Vol 43 (1) ◽  
Author(s):  
Loïc Le Marchand
Keyword(s):  
Colorectal Cancer ◽  
Aromatic Amines ◽  
Quantitative Methods ◽  
Biological Effects ◽  
Epidemiological Studies ◽  
Epidemiologic Studies ◽  
Red Meat ◽  
Heterocyclic Aromatic Amines ◽  
Intermediate Phenotype ◽  
Cancer Multiple

AbstractSince Dr. Sugimura’s discovery of heterocyclic aromatic amines (HAA) in broiled fish, many epidemiological studies have been conducted to investigate their role in human cancers, often focusing on colorectal cancer. The difficulty in measuring HAA exposure from meat and fish intake in these studies has resulted in inconsistent findings. Because studying individuals who may be particularly susceptible to the carcinogenic effects of HAA might facilitate the demonstration of a link with cancer, multiple studies have focused on individuals with the high activity phenotype for CYP1A2 and/or NAT2, the two main metabolic enzymes involved in the bioactivation of HAA. These investigations have also yielded inconsistent results. Two recent large pooled analyses of colorectal cancer studies have helped clarify the overall evidence. One was conducted in whites and reported no interaction of red meat intake and NAT2 genotype on risk in Whites. The other was conducted in Japanese and African Americans, two populations with high rates of the disease and a prevalence of the at-risk rapid NAT2 phenotype 10- and 2-fold greater than in whites, respectively. In those groups, a significant interaction was found, with the association of red meat with colorectal cancer being strongest among individuals with the rapid NAT2 phenotype, intermediate among those with the intermediate phenotype and not significant among those with the slow NAT2 phenotype. Recent research on biomarkers has focused on PhIP hair content, as a marker of exposure to HAA, and on DNA adducts using new sensitive quantitative methods, as markers of early biological effects. These advances, when brought to bear, may contribute greatly to the further elucidation of the carcinogenicity of HAA in humans.

Attitude and Acceptability of the Self-Sampling in HPV Carrier Women

2021 ◽  
pp. 154041532110015
Author(s):  
Gloria Maricela Guerra Rodríguez ◽  
Octavio Augusto Olivares Ornelas ◽  
Héctor Manuel Gil Vázquez ◽  
Dalia Sarahí Silguero Esquivel ◽  
Jane Dimmitt Champion
Keyword(s):  
Cervical Cancer ◽  
Age At Onset ◽  
Cervical Dysplasia ◽  
Diagnostic Procedures ◽  
Mexican Women ◽  
Cross Sectional ◽  
Convenience Sample ◽  
Positive Attitudes ◽  
Multiple Strains ◽  
Cancer Multiple

Human papillomavirus (HPV) is a primary cause of cervical cancer. Multiple strains of HPV lead to cervical intraepithelial injuries that later progress to cervical cancer. The purpose of this study was to assess attitudes toward and acceptability of self-sampling among Mexican women who have HPV. Methods: The descriptive, cross-sectional design included a convenience sample of Mexican women with a previous diagnosis of cervical dysplasia. Results: Women ( n = 61) were young adults ( M = 27 years, SD = 6.92) reporting single marital status (55%) and sexually active (93%). Mean age at onset of sexual activity was 17 years; a majority of women (78.8%) had more than one sexual partner in their lifetime with 56.6% reporting between two and five partners. All (100%) of the women indicated that they would “choose self-sampling for HPV detection” and would recommend it to other women. Concerning “attitudes toward HPV,” the women responded that it is necessary to comply with HPV treatment and understand that preventative measures can avoid HPV transmission. Conclusion: Women reported high acceptability for self-sampling and positive attitudes toward HPV diagnostic procedures. Women indicated substantial interest in learning more about HPV, its transmission, preventive measures, routine testing, and recommended self-sampling for HPV detection.

Multiple Therapy in the Treatment Program of a Mental Hospital

Psychiatry ◽  
1953 ◽  
Vol 16 (1) ◽  
pp. 21-26 ◽  
Author(s):  
Jarl E. Dyrud ◽  
Margaret J. Rioch
Keyword(s):  
Treatment Program ◽  
Mental Hospital ◽  
Multiple Therapy

DEVELOPMENT OF COMPOSITION AND PRODUCTION TECHNOLOGIES PAZOPANIB TABLET 400 MG

2021 ◽  
pp. 83-87
Author(s):  
А.Е. ЖУМАКАНОВА ◽  
А.Р. ИБРАГИМОВА ◽  
Г.О. УСТЕНОВА
Keyword(s):  
Targeted Therapy ◽  
Cancer Cells ◽  
Soft Tissue Sarcomas ◽  
Targeted Drugs ◽  
Cancer Treatments ◽  
Production Technologies ◽  
Cancer Multiple ◽  
Or Genes ◽  
Cancer Targeted Therapy ◽  
Better Than

Таргетные методы лечения рака - это лекарства, нацеленные на определенные части раковых клеток, такие как белки или гены, которые способствуют росту и распространению раковых клеток. Трагетная терапия при определенных типах раках является эффективной. При некоторых типах рака таргетная терапия может работать лучше, чем другие методы лечения. От английского target - цель, мишень. Природа таргетных лекарств очень специфична и при разработке они направляются под конкретный мутировавший ген раковой клетки определенного вида опухолевого новообразования. В настоящий момент разными странами разработаны эффективные таргетные препараты для лечения различных генетических форм рака молочной железы, множественной миеломы, лимфомы, рака предстательной железы, меланомы, сарком мягких тканей [1]. Targeted cancer treatments are medicaments that target specific parts of cancer cells, such as proteins or genes that growing power and spread of cancer cells. Targeted therapy for certain types of cancers is effective. For some types of cancer, targeted therapy may work better than other treatments. The nature of targeted drugs is very specific and when developed, they are directed to a specific mutated gene of a cancer cell of a certain type of tumor. Currently, different countries have developed effective targeted drugs for the treatment of various genetic forms of breast cancer, multiple myeloma, lymphoma, prostate cancer, melanoma, soft tissue sarcomas.

Tumor spheroids and organoids as preclinical model systems

2021 ◽  
Vol 33 (3) ◽  
pp. 229-234
Author(s):  
Aria Baniahmad
Keyword(s):  
Apoptotic Cell ◽  
Model Systems ◽  
Adherent Cell ◽  
Preclinical Model ◽  
Cancer Tissue ◽  
Tumor Spheroids ◽  
Cancer Models ◽  
Cancer Multiple ◽  
Cell Cell

Abstract The generation of three-dimensional (3D) cancer models is a novel and fascinating development in the study of personalized medicine and tumor-specific drug delivery. In addition to the classical two-dimensional (2D) adherent cell culture models, 3D spheroid and organoid cancer models that mimic the microenvironment of cancer tissue are emerging as an important preclinical model system. 3D cancer models form, similar to cancer, multiple cell–cell and cell–extracellular matrix interactions and activate different cellular cascades/pathways, like proliferation, quiescence, senescence, and necrotic or apoptotic cell death. Further, it is possible to analyze genetic variations and mutations, the microenvironment of cell–cell interactions, and the uptake of therapeutics and nanoparticles in nanomedicine. Important is also the analysis of cancer stem cells (CSCs), which could play key roles in resistance to therapy and cancer recurrence. Tumor spheroids can be generated from one tumor-derived cell line or from co-culture of two or more cell lines. Tumor organoids can be derived from tumors or may be generated from CSCs that differentiate into multiple facets of cancerous tissue. Similarly, tumorspheres can be generated from a single CSC. By transplanting spheroids and organoids into immune-deficient mice, patient-derived xenografts can serve as a preclinical model to test therapeutics in vivo. Although the handling and analysis of 3D tumor spheroids and organoids is more complex, it will provide insights into various cancer processes that cannot be provided by 2D culture. Here a short overview of 3D tumor systems as preclinical models is provided.

scholarly journals Pseudomyxoma Peritonei Originating from Transverse Colon Mucinous Adenocarcinoma: A Case Report and Literature Review

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Yingbo Gong ◽  
Xin Wang ◽  
Zhi Zhu
Keyword(s):  
Literature Review ◽  
Pseudomyxoma Peritonei ◽  
Transverse Colon ◽  
Mucinous Adenocarcinoma ◽  
Lung Metastases ◽  
Metastatic Cancer ◽  
Genetic Profile ◽  
Low Grade ◽  
Extensive Literature ◽  
Cancer Multiple

Background. Pseudomyxoma peritonei (PMP) is a rare neoplasm involving the peritoneum. Most PMPs are low-grade appendicular mucinous neoplasms (LAMNs). There have been no reports of PMP originating from a transverse colonic mucinous adenocarcinoma and causing metastatic mucinous adenocarcinoma. Case Presentation. We report a 46-year-old woman who presented with a right abdominal mass of more than 4-month duration. Transverse colonic mucinous adenocarcinoma, PMP, and ovarian metastatic mucinous adenocarcinoma were diagnosed. The patient’s diet was normal, and she had no abdominal pain or bloating. The abdomen mass increased in the month before treatment. After chemotherapy, the transverse colon mass and ovarian giant cyst were resected and about 2000 mL of gelatinous tumor tissue was removed. Postoperative histology confirmed PMP from the transverse colonic mucinous adenocarcinoma, ovarian metastatic mucinous adenocarcinoma, and mesocolon metastatic cancer. Multiple lung metastases appeared 8 months after surgery. The patient died 29 months after surgery because of an inability to eat and poor nutrition. A systematic literature review of the management and outcome of all known similar cases is also presented. Conclusions. This is the first report of PMP originating from a transverse colonic mucinous adenocarcinoma. It was diagnosed during resective surgery, involved ovarian metastasis, and survival was short. We did an extensive literature review in order to describe the clinical characteristics, histopathological findings, genetic profile, and potential treatments of PMP caused by nonappendiceal mucinous adenocarcinoma.

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