ChemInform Abstract: INTERPROTON DISTANCES FOR THE β-TURN RESIDUES OF THE PEPTIDE GRAMICIDIN S DETERMINED FROM NUCLEAR OVERHAUSER EFFECT RATIOS

1978 ◽  
Vol 9 (49) ◽  
Author(s):  
C. R. JONES ◽  
C. T. SIKAKANA ◽  
M. KUO ◽  
W. A. GIBBONS
Keyword(s):  
Nuclear Overhauser Effect ◽  
Gramicidin S ◽  
Overhauser Effect ◽  
Nuclear Overhauser ◽  
Interproton Distances

scholarly journals An investigation into the solution structures of two self-complementary DNA oligomers, 5′-d(C-G-T-A-C-G) and 5′-d(A-C-G-C-G-C-G-T), by means of nuclear-Overhauser-enhancement measurements

1984 ◽  
Vol 221 (3) ◽  
pp. 723-726 ◽  
Author(s):  
A M Gronenborn ◽  
G M Clore ◽  
B J Kimber
Keyword(s):  
Nuclear Overhauser Effect ◽  
Type Structure ◽  
Dna Oligomers ◽  
Proton Proton ◽  
Solution Structures ◽  
Interproton Distance ◽  
Overhauser Effect ◽  
Distance Data ◽  
Nuclear Overhauser ◽  
Interproton Distances

A 500 MHz 1H-n.m.r. study on two self-complementary alternating pyrimidine-purine oligodeoxyribonucleotides, 5′-d(C-G-T-A-C-G) and 5′-d(A-C-G-C-G-C-G-T), is presented. By using the proton-proton nuclear Overhauser effect virtually complete assignments are obtained and a large number of interproton distances [113 in the case of 5′-d(C-G-T-A-C-G) and 79 in the case of 5′-d(A-C-G-C-G-C-G-T)], both intra- and inter-nucleotide, are determined. The interproton-distance data are consistent with an overall right-handed B-DNA-type structure for both oligonucleotides, in agreement with their B-type c.d. spectra. However, whereas 5′-d(C-G-T-A-C-G) adopts a conventional B-type structure with a mononucleotide repeating unit, the interproton-distance data provide evidence that 5′-d(A-C-G-C-G-C-G-T) has a dinucleotide repeating unit consisting of alternation in glycosidic bond and sugar pucker conformations.

New ways of nulling 15N resonances by the nuclear overhauser effect: Gramicidin S

1975 ◽  
Vol 19 (2) ◽  
pp. 255-258 ◽  
Author(s):  
Geoffrey E Hawkes ◽  
William M Litchman ◽  
Edward W Randall
Keyword(s):  
Nuclear Overhauser Effect ◽  
Gramicidin S ◽  
Overhauser Effect ◽  
Nuclear Overhauser

Analysis of short interproton distances in proline peptides as a guide in the interpretation of nuclear Overhauser effects

1988 ◽  
Vol 53 (11) ◽  
pp. 2801-2809 ◽  
Author(s):  
Chandrashekharan Ramakrishnan ◽  
Ramanathan Sowdhamini ◽  
Padmanabhan Balaram
Keyword(s):  
Nuclear Overhauser Effect ◽  
Model Systems ◽  
Pyrrolidine Ring ◽  
Ramachandran Map ◽  
Overhauser Effect ◽  
Ring Puckering ◽  
Nuclear Overhauser ◽  
Nuclear Overhauser Effects ◽  
Interproton Distances ◽  
Helical Region

The conformational dependence of interproton distances in model proline peptides has been investigated in order to facilitate interpretation of the results of Nuclear Overhauser Effect (NOE) studies on such peptides. For this purpose two model systems, namely, Ac-Pro-NHMe and Ac-Pro-X-NHMe have been chosen and used. In the former, short interproton distances detectable in NOE experiments permit a clear distinction between conformations with Pro ψ = -300 (helical region) and those in which ψ is around 1200 (polyproline region). For the latter, the variation of distances between the protons of methyl amide and the Pro ring have been studied by superimposing on the Ramachandran map in the (φ3, ψ3) plane. The results show that β-turns and non-β-turn conformations can be readily distinguished from NOE data and such long range NOEs should be detectable for specific non-β-turn conformations. NOEs involving Cβ and Cγ protons are particularly sensitive to the state of pyrrolidine ring puckering.

1H NMR studies of [N-MeAib1, Tyr(Me)4]ANGII and [N-MeAib1, Tyr(Me)4, Ile8]ANGII in dimethylsulfoxide by nuclear Overhauser effect (NOE) enhancement spectroscopy: cis-trans Isomerism of the His-Pro bond

1990 ◽  
Vol 55 (4) ◽  
pp. 1106-1111 ◽  
Author(s):  
John Matsoukas ◽  
Paul Cordopatis ◽  
Raghav Yamdagni ◽  
Graham J. Moore
Keyword(s):  
1H Nmr ◽  
Nuclear Overhauser Effect ◽  
Nmr Studies ◽  
Restricted Rotation ◽  
Overhauser Effect ◽  
Major Isomer ◽  
Conformational Properties ◽  
Nuclear Overhauser

The conformational properties of the Sarmesin analogues [N-MeAib1, Tyr(Me)4]ANGII and [N-MeAib1, Tyr(Me)4, Ile8]ANGII in hexadeutero-dimethysulfoxide were investigated by Nuclear Overhauser Effect (NOE) Enhancement Studies. Cis-trans isomers (ratio 1 : 6) due to restricted rotation of the His-Pro bond were observed. Interresidue interactions between the His Cα proton and the two Pro Cδ protons revealed that the major isomer was the trans.

scholarly journals Cylindromicin from Arctic-Derived Fungus Tolypocladium sp. SCSIO 40433

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 1080
Author(s):  
Imran Khan ◽  
Jing Peng ◽  
Zhuangjie Fang ◽  
Wei Liu ◽  
Wenjun Zhang ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Nuclear Overhauser Effect ◽  
Inhibition Activity ◽  
Tyrosinase Inhibition ◽  
Bioactive Natural Products ◽  
Chemical Structures ◽  
Overhauser Effect ◽  
Spectroscopic Analyses ◽  
Potential Resource ◽  
Nuclear Overhauser

The fungus strain SCSIO 40433 was isolated from an Arctic-derived glacier sediment sample and characterized as Tolypocladium cylindrosporum. A new compound, cylindromicin (1), and seven known secondary metabolites (2–8) were isolated from this strain. The chemical structures of these compounds were elucidated by comprehensive spectroscopic analyses. Cylindromicin (1) featured a 3,4-dihydro-2H-pyran skeleton. The absolute configuration of compound 1 was assigned via interpretation of key Nuclear Overhauser Effect Spectroscopy (NOESY) correlations and Electronic Circular Dichroism (ECD) calculation. Cylindromicin (1) exhibited significant tyrosinase inhibition activity. This study highlights Polar fungi as a potential resource for new bioactive natural products.

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