ChemInform Abstract: NEW SYNTHESIS OF THIOPHENE DERIVATIVES BY THE REACTION OF PHOSPHORUS PENTASULFIDE WITH PRODUCTS OF THE ELECTROPHILIC ADDITION OF CARBOXYLIC ACID CHLORIDES TO ALLYL AND METHALLYL CHLORIDES

1978 ◽  
Vol 9 (12) ◽  
Author(s):  
A. G. ISMAILOV ◽  
E. I. MAMEDOV ◽  
V. G. IBRAGIMOV
Keyword(s):  
Carboxylic Acid ◽  
Electrophilic Addition ◽  
Acid Chlorides ◽  
Phosphorus Pentasulfide ◽  
New Synthesis ◽  
Thiophene Derivatives

ChemInform Abstract: A New Synthesis of β,γ-Alkenyl Carboxylic Acids from α,β-Alkenyl Carboxylic Acid Chlorides and α,β-Alkenyl Aldehydes with One-Carbon Elongation.

ChemInform ◽  
2010 ◽  
Vol 33 (12) ◽  
pp. no-no
Author(s):  
Tsuyoshi Satoh ◽  
Akira Nakamura ◽  
Atsuko Iriuchijima ◽  
Yasumasa Hayashi ◽  
Ko-ichi Kubota
Keyword(s):  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Acid Chlorides ◽  
New Synthesis

scholarly journals REACTION OF CHLOROANHYDRIDES OF CYCLOALKANECARBOXILIC ACIDS WITH SOME ALLYLIC CHLORIDES

2021 ◽  
Vol 19 (3) ◽  
pp. 179-185
Author(s):  
V.A. Guseinova ◽  
◽  
G.A. Zaidova ◽  
E.I. Mammadov ◽  
◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Electrophilic Addition ◽  
Acid Chlorides ◽  
Substituted Furans

The reactions of electrophilic addition of cycloalkane carboxylic acid chlorides with allyl chlorides were studied. It was found, that depending on the chloride structures, 2- and 2,4-substituted furans, 1-R-3,4- dichloro-2-butene-1-ones and 1-R-3,4,4-trichloro-1-butanones were obtained.

A new synthesis of β,γ-alkenyl carboxylic acids from α,β-alkenyl carboxylic acid chlorides and α,β-alkenyl aldehydes with one-carbon elongation

Tetrahedron ◽  
2001 ◽  
Vol 57 (48) ◽  
pp. 9689-9696 ◽  
Author(s):  
Tsuyoshi Satoh ◽  
Akira Nakamura ◽  
Atsuko Iriuchijima ◽  
Yasumasa Hayashi ◽  
Ko-ichi Kubota
Keyword(s):  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Acid Chlorides ◽  
New Synthesis

New synthesis of indole-7-carboxylic acid

1986 ◽  
Vol 22 (1) ◽  
pp. 36-37 ◽  
Author(s):  
V. I. Dulenko ◽  
Yu. A. Nikolyukin
Keyword(s):  
Carboxylic Acid ◽  
New Synthesis

Synthesis of 1-acyl- and 1-(thioacyl)-4-benzylpiperazines as potential antidepressants

1990 ◽  
Vol 55 (7) ◽  
pp. 1817-1827 ◽  
Author(s):  
Vojtěch Kmoníček ◽  
Emil Svátek ◽  
Jiří Holubek ◽  
Miroslav Ryska ◽  
Martin Valchář ◽  
...  
Keyword(s):  
Benzoic Acid ◽  
Thionyl Chloride ◽  
Antidepressant Activity ◽  
Acid Chlorides ◽  
Phosphorus Pentasulfide ◽  
Antidepressant Agent ◽  
Dimethylaminobenzoic Acid ◽  
Amino Amides

2-Nitro, 3-nitro- and 4-nitrobenzoyl chloride were reacted with 1-benzylpiperazine in benzene in the presence of triethylamine and gave the amides IV-VI, the first of which is considered a bioisostere of the antidepressant agent piberaline (I). 2-Dimethylamino-, 3-dimethylamino- and 4-dimethylaminobenzoic acid were treated with thionyl chloride in benzene in the presence of triethylamine or pyridine, and the acid chlorides formed were reacted in situ with 1-benzylpiperazine affording the amides VII-IX. The amides I and IV-VI were transformed by treatment with phosphorus pentasulfide in pyridine to the thioamides X-XIII. 4-(Dimethylaminomethyl)benzoic acid was reacted with 1-benzylpiperazine in dimethylformamide in the presence of N,N'-carbonyldiimidazole and afforded the amide XIV. Heating of ethyl 5-methylimidazole-4-carboxylate with 1-benzylpiperazine to 200-210 °C gave the amide XV together with the unexpected 1-benzyl-4-ethylpiperazine (XVI). The oily or crystalline bases of the amino amides or thioamides were mostly transformed to crystalline salts and characterized by spectra. Out of the compounds prepared only X (V⁄FB-17 070) and XIV (V⁄FB-17 114) showed indications of efficacy in tests which are considered indicative of antidepressant activity. Compounds VII, VIII, and X appeared to be mildly antidopaminergic - similarly like piberaline (I), and compounds IV, V, XI, XIV, and XV on the contrary showed signs of dopaminominetic activity.

scholarly journals Synthesis and Characterization of the Germathioacid Chloride Coordinated by an N-Heterocyclic Carbene §

Inorganics ◽  
2018 ◽  
Vol 6 (3) ◽  
pp. 76 ◽  
Author(s):  
Yasunobu Egawa ◽  
Chihiro Fukumoto ◽  
Koichiro Mikami ◽  
Nobuhiro Takeda ◽  
Masafumi Unno
Keyword(s):  
Carboxylic Acid ◽  
Density Functional ◽  
Dft Calculation ◽  
Acid Chlorides ◽  
Carboxylic Acid Chloride ◽  
Functional Theory ◽  
Nitrogen Ligands ◽  
Bond Property ◽  
Nitrogen Bonds

Carboxylic acid chlorides are useful substrates in organic chemistry. Many germanium analogues of carboxylic acid chloride have been synthesized so far. Nevertheless, all of the reported germathioacid chlorides use bidentate nitrogen ligands and contain germanium-nitrogen bonds. Our group synthesized germathioacid chloride, Ge(S)Cl{C6H3-2,6-Tip2}(Im-i-Pr2Me2), using N-heterocyclic carbene (Im-i-Pr2Me2). As a result of density functional theory (DFT) calculation, it was found that electrons are localized on sulfur, and the germanium-sulfur bond is a single bond with a slight double bond property.

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