Tailor‐Made Amino Acids in Pharmaceutical Industry: Synthetic Approaches to Aza‐Tryptophan Derivatives

2021 ◽  
Author(s):  
Jianlin Han ◽  
Nataliya V. Lyutenko ◽  
Alexander E. Sorochinsky ◽  
Ayaka Okawara ◽  
Hiroyuki Konno ◽  
...  
Keyword(s):  
Amino Acids ◽  
Pharmaceutical Industry ◽  
Synthetic Approaches ◽  
Tryptophan Derivatives

Frontispiece: Tailor‐Made Amino Acids in Pharmaceutical Industry: Synthetic Approaches to Aza‐Tryptophan Derivatives

2021 ◽  
Vol 27 (70) ◽  
Author(s):  
Jianlin Han ◽  
Nataliya V. Lyutenko ◽  
Alexander E. Sorochinsky ◽  
Ayaka Okawara ◽  
Hiroyuki Konno ◽  
...  
Keyword(s):  
Amino Acids ◽  
Pharmaceutical Industry ◽  
Synthetic Approaches ◽  
Tryptophan Derivatives

Tailor-Made α-Amino Acids in the Pharmaceutical Industry: Synthetic Approaches to (1R,2S)-1-Amino-2-vinylcyclopropane-1-carboxylic Acid (Vinyl-ACCA)

2016 ◽  
Vol 2016 (16) ◽  
pp. 2757-2774 ◽  
Author(s):  
Tatsunori Sato ◽  
Kunisuke Izawa ◽  
José Luis Aceña ◽  
Hong Liu ◽  
Vadim A. Soloshonok
Keyword(s):  
Amino Acids ◽  
Carboxylic Acid ◽  
Pharmaceutical Industry ◽  
Synthetic Approaches

scholarly journals Cyclodextrin Multicomponent Complexes: Pharmaceutical Applications

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1099
Author(s):  
Virginia Aiassa ◽  
Claudia Garnero ◽  
Marcela R. Longhi ◽  
Ariana Zoppi
Keyword(s):  
Amino Acids ◽  
Pharmaceutical Industry ◽  
Drug Effects ◽  
Water Soluble ◽  
Therapeutic Drug ◽  
Water Soluble Polymers ◽  
Soluble Polymers ◽  
Pharmaceutical Applications ◽  
Auxiliary Substance ◽  
Acids And Bases

Cyclodextrins (CDs) are naturally available water-soluble cyclic oligosaccharides widely used as carriers in the pharmaceutical industry for their ability to modulate several properties of drugs through the formation of drug–CD complexes. The addition of an auxiliary substance when forming multicomponent complexes is an adequate strategy to enhance complexation efficiency and to facilitate the therapeutic applicability of different drugs. This review discusses multicomponent complexation using amino acids; organic acids and bases; and water-soluble polymers as auxiliary excipients. Special attention is given to improved properties by including information on the solubility, dissolution, permeation, stability and bioavailability of several relevant drugs. In addition, the use of multicomponent CD complexes to enhance therapeutic drug effects is summarized.

scholarly journals Amino acids with fluorinated olefinic motifs – synthetic approaches

ARKIVOC ◽  
2020 ◽  
Vol 2021 (2) ◽  
pp. 99-117
Author(s):  
Katarzyna Salamon-Krokosz ◽  
Katarzyna Koroniak-Szejn ◽  
Henryk Koroniak
Keyword(s):  
Amino Acids ◽  
Synthetic Approaches

scholarly journals Synthetic Approaches to a Challenging and Unusual Structure—An Amino-Pyrrolidine Guanine Core

Molecules ◽  
2020 ◽  
Vol 25 (4) ◽  
pp. 797
Author(s):  
Rafael Rippel ◽  
Luís Pinheiro ◽  
Mónica Lopes ◽  
Ana Lourenço ◽  
Luísa M. Ferreira ◽  
...  
Keyword(s):  
Amino Acids ◽  
Intramolecular Cyclization ◽  
Oxidative Decarboxylation ◽  
Unusual Structure ◽  
Racemic Form ◽  
Natural Alkaloid ◽  
Synthetic Approaches ◽  
First Time

The synthesis of an unreported 2-aminopyrrolidine-1-carboxamidine unit is here described for the first time. This unusual and promising structure was attained through the oxidative decarboxylation of amino acids using the pair of reagents, silver(I)/peroxydisulfate (Ag(I)/S2O82−) followed by intermolecular (in the case of l-proline derivative) and intramolecular trapping (in the case of acyl l-arginine) by N-nucleophiles. The l-proline approach has a broader scope for the synthesis of 2-aminopyrrolidine-1-carboxamidine derivatives, whereas the intramolecular cyclization afforded by the l-acylarginines, when applied, results in higher yields. The former allowed the first synthesis of cernumidine, a natural alkaloid isolated in 2011 from Solanum cernuum Vell, as its racemic form.

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