A Nickel(II)‐Mediated Thiocarbonylation Strategy for Carbon Isotope Labeling of Aliphatic Carboxamides

2021 ◽  
Author(s):  
Simon S. Pedersen ◽  
Aske S. Donslund ◽  
Jesper H. Mikkelsen ◽  
Oskar S. Bakholm ◽  
Florian Papp ◽  
...  
Keyword(s):  
Carbon Isotope ◽  
Isotope Labeling

scholarly journals Cover Feature: A Nickel(II)‐Mediated Thiocarbonylation Strategy for Carbon Isotope Labeling of Aliphatic Carboxamides (Chem. Eur. J. 24/2021)

2021 ◽  
Vol 27 (24) ◽  
pp. 6998-6998
Author(s):  
Simon S. Pedersen ◽  
Aske S. Donslund ◽  
Jesper H. Mikkelsen ◽  
Oskar S. Bakholm ◽  
Florian Papp ◽  
...  
Keyword(s):  
Carbon Isotope ◽  
Isotope Labeling ◽  
J 24

Charge distribution in turbostratic few-layer graphene studied by carbon isotope labeling

Carbon ◽  
2021 ◽  
Author(s):  
Pingping Zhuang ◽  
Jing Liu ◽  
Junjie Huang ◽  
Chao Dou ◽  
Weiwei Cai ◽  
...  
Keyword(s):  
Carbon Isotope ◽  
Charge Distribution ◽  
Isotope Labeling ◽  
Layer Graphene ◽  
Few Layer Graphene

scholarly journals Carbon isotope labeling of carbamates by late-stage [11C], [13C] and [14C]carbon dioxide incorporation

2020 ◽  
Vol 56 (78) ◽  
pp. 11677-11680
Author(s):  
Antonio Del Vecchio ◽  
Alex Talbot ◽  
Fabien Caillé ◽  
Arnaud Chevalier ◽  
Antoine Sallustrau ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Carbon Isotope ◽  
Carbon Isotopes ◽  
Late Stage ◽  
Building Block ◽  
Isotope Labeling

A procedure which allows labelling cyclic carbamates with all carbon isotopes has been developed. This protocol valorizes carbon dioxide, the universal building block for radiolabeling. A series of pharmaceuticals were obtained and a disconnection/reconnection strategy was implemented.

Investigation on the Stoichiometry of Carbon Dioxide in Isotope-Exchange Reactions with Phenylacetic Acids

Synlett ◽  
2021 ◽  
Author(s):  
Davide Audisio ◽  
Alex Talbot ◽  
Antoine Sallustrau ◽  
Amélie Goudet ◽  
Frédéric Taran
Keyword(s):  
Carbon Dioxide ◽  
Carbon Isotope ◽  
Isotope Exchange ◽  
Isotope Labeling ◽  
Exchange Reactions ◽  
Major Interest ◽  
Carbon Dioxide Co2 ◽  
Dilution Effects ◽  
Product Outcome ◽  
Insight Into

AbstractThe functionalization of carbon dioxide (CO2) as a C1 building block has attracted enormous attention. Carboxylation reactions, in particular, are of major interest for applications in isotope labeling. Due to the inexpensive nature of CO2, information about its stoichiometric use is generally unavailable in the literature. Because of the rarity and limited availability of CO2 isotopomers, this parameter is of concern for applications in carbon-isotope labeling. We investigated the effects of the stoichiometry of labeled CO2 on carbon isotope exchange of phenyl­acetic acids. Both thermal and photocatalytic procedures were studied, providing insight into product outcome and isotope incorporation. Preliminary results on isotope-dilution effects of carbonate bases in photocatalytic carboxylation reactions have also been obtained.

A free-air system for long-term stable carbon isotope labeling of adult forest trees

Trees ◽  
2010 ◽  
Vol 25 (2) ◽  
pp. 187-198 ◽  
Author(s):  
Thorsten E. E. Grams ◽  
Herbert Werner ◽  
Daniel Kuptz ◽  
Wilma Ritter ◽  
Frank Fleischmann ◽  
...  
Keyword(s):  
Carbon Isotope ◽  
Isotope Labeling ◽  
Stable Carbon Isotope ◽  
Forest Trees ◽  
Stable Carbon ◽  
Free Air ◽  
Air System

Assessment of Carbon Allocation with Stable Carbon Isotope Labeling

1990 ◽  
Vol 82 (1) ◽  
pp. 18-21 ◽  
Author(s):  
Tony J. Svejcar ◽  
Thomas W. Boutton ◽  
James D. Trent
Keyword(s):  
Carbon Isotope ◽  
Isotope Labeling ◽  
Carbon Allocation ◽  
Stable Carbon Isotope ◽  
Stable Carbon

scholarly journals Robust and General Procedure for Carbon Isotope Labeling of Linear Urea Derivatives with Carbon Dioxide

2021 ◽  
Author(s):  
Victor Babin ◽  
Antoine Sallustrau ◽  
Olivier Loreau ◽  
Fabien Caillé ◽  
Amélie Goudet ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Full Article ◽  
Carbon Isotope ◽  
Carbon Isotopes ◽  
Isotope Labeling ◽  
General Procedure ◽  
Urea Derivatives ◽  
Living Organisms ◽  
Approved Drugs ◽  
Fda Approved Drugs

Carbon isotope labeling is a traceless technology, which allows tracking the fate of organic compounds either in the environment or in living organisms. Despite recent advances in the field, the development of robust and general technologies remains a significant task. This full article reports on a general approach to label urea derivatives with all carbon isotopes, including <sup>14</sup>C and <sup>11</sup>C. Based on a Staudinger aza-Wittig sequence, it provides access to all aliphatic/aromatic urea combinations as well as to semicarbazides, sulfonylureas, hydroxyl ureas, and simple terminal ureas. A de-risking approach was developed to evaluate the robustness of the reaction. This technology is based on [<sup>14</sup>C]CO<sub>2</sub> screening that allowed to investigate the tolerance of the procedure with most representative heterocycles and functional groups found in FDA approved drugs.

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