Construction of Hyaluronic Acid Covered Hierarchically Porous MIL‐nanoMOF for Loading and Controlled Release of Doxorubicin

2020 ◽  
Author(s):  
Yang Yang ◽  
Yi-Ran Yao ◽  
Ya-Jun Jin ◽  
Xin Jia
Keyword(s):  
Hyaluronic Acid ◽  
Controlled Release ◽  
Hierarchically Porous

scholarly journals Controlled Release of Interleukin-1 Receptor Antagonist from Hyaluronic Acid-Chitosan Microspheres Attenuates Interleukin-1β-Induced Inflammation and Apoptosis in Chondrocytes

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Bo Qiu ◽  
Ming Gong ◽  
Qi-Ting He ◽  
Pang-Hu Zhou
Keyword(s):  
Hyaluronic Acid ◽  
Controlled Release ◽  
Receptor Antagonist ◽  
Release Kinetics ◽  
Quantitative Polymerase Chain Reaction ◽  
Interleukin 1 ◽  
B Cell Lymphoma ◽  
Chondrocyte Apoptosis ◽  
Burst Release ◽  
Interleukin 1 Receptor Antagonist

This paper investigates the protective effect of interleukin-1 receptor antagonist (IL-1Ra) released from hyaluronic acid chitosan (HA-CS) microspheres in a controlled manner on IL-1β-induced inflammation and apoptosis in chondrocytes. The IL-1Ra release kinetics was characterized by an initial burst release, which was reduced to a linear release over eight days. Chondrocytes were stimulated with 10 ng/ml IL-1β and subsequently incubated with HA-CS-IL-1Ra microspheres. The cell viability was decreased by IL-1β, which was attenuated by HA-CS-IL-1Ra microspheres as indicated by an MTT assay. ELISA showed that HA-CS-IL-1Ra microspheres inhibited IL-1β-induced inflammation by attenuating increases in NO2- and prostaglandin E2 levels as well as increase in glycosaminoglycan release. A terminal deoxyribonucleotide transferase deoxyuridine triphosphate nick-end labeling assay revealed that the IL-1β-induced chondrocyte apoptosis was decreased by HA-CS-IL-1Ra microspheres. Moreover, HA-CS-IL-1Ra microspheres blocked IL-1β-induced chondrocyte apoptosis by increasing B-cell lymphoma 2 (Bcl-2) and decreasing Bcl-2-associated X protein and caspase-3 expressions at mRNA and protein levels, as indicated by reverse-transcription quantitative polymerase chain reaction and western blot analysis, respectively. The results of the present study indicated that HA-CS-IL-1Ra microspheres as a controlled release system of IL-1Ra possess potential anti-inflammatory and antiapoptotic properties in rat chondrocytes due to their ability to regulate inflammatory factors and apoptosis associated genes.

Controlled release behavior of bioactive molecules from photo-reactive hyaluronic acid-alginate scaffolds

2006 ◽  
Vol 14 (5) ◽  
pp. 530-538 ◽  
Author(s):  
Hye Sung Nam ◽  
Jeongho An ◽  
Dong June Chung ◽  
Ji-Heung Kim ◽  
Chong-Pyoung Chung
Keyword(s):  
Hyaluronic Acid ◽  
Controlled Release ◽  
Bioactive Molecules ◽  
Release Behavior
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