Dinitrogen Fixation: Rationalizing Strategies Utilizing Molecular Complexes

Frontispiece: Dinitrogen Fixation: Rationalizing Strategies Utilizing Molecular Complexes

Chemistry - A European Journal ◽

10.1002/chem.202181261 ◽

2021 ◽

Vol 27 (12) ◽

Author(s):

Fabio Masero ◽

Marie A. Perrin ◽

Subal Dey ◽

Victor Mougel

Keyword(s):

Molecular Complexes ◽

Dinitrogen Fixation

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Probing massive cold cores discovered by ISO in quiescent galactic molecular complexes

EAS Publications Series ◽

10.1051/eas:2002068 ◽

2002 ◽

Vol 4 ◽

pp. 133-133

Author(s):

D. Teyssier ◽

P. Hennebelle ◽

M. Pérault

Keyword(s):

Molecular Complexes

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Dipole moments and molecular complexes

Journal de Chimie Physique ◽

10.1051/jcp/1964610125 ◽

1964 ◽

Vol 61 ◽

pp. 125-131 ◽

Cited By ~ 11

Author(s):

J. W. Smith

Keyword(s):

Dipole Moments ◽

Molecular Complexes

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Bond order indices of iodine: from molecular complexes to crystals

Журнал структурной химии ◽

10.26902/jsc20180819 ◽

2018 ◽

Vol 59 (8) ◽

Keyword(s):

Bond Order ◽

Molecular Complexes

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Influence of β-Cyclodextrin and Hydroxypropyl-β-Cyclodextrin on Enhancement of Solubility and Dissolution of Isradipine

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2017.10.3.8 ◽

2017 ◽

Vol 10 (3) ◽

pp. 3752-3757

Author(s):

Narendar D ◽

Ettireddy S

Keyword(s):

Inclusion Complex ◽

Dissolution Rate ◽

Solid Dispersions ◽

Physical Stability ◽

Molecular Complexes ◽

In Vitro Dissolution ◽

Molar Ratio ◽

Phase Solubility ◽

Cyclodextrin Complexation

The content of this investigation was to study the influence of β-cyclodextrin and hydroxy propyl-β-cyclodextrin complexation on enhancement of solubility and dissolution rate of isradipine. Based on preliminary phase solubility studies, solid complexes prepared by freeze drying method in 1:1 molar ratio were selected and characterized by DSC for confirmation of complex formation. Prepared solid dispersions were evaluated for drug content, solubility and in vitro dissolution. The physical stability of optimized formulation was studied at refrigerated and room temperature for 2 months. Solid state characterization of optimized complex performed by DSC and XRD studies. Dissolution rate of isradipine was increased compared with pure drug and more with HP-β-CD inclusion complex than β-CD. DSC and XRD analyzes that drug was in amorphous form, when the drug was incorporated as isradipine β-CD and HP-β-CD inclusion complex. Stability studies resulted in low or no variations in the percentage of complexation efficiency suggesting good stability of molecular complexes. The results conclusively demonstrated that the enhancement of solubility and dissolution rate of isradipine by drug-cyclodextrin complexation was achieved.

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