scholarly journals Smart Protein‐Based Formulation of Dendritic Mesoporous Silica Nanoparticles: Toward Oral Delivery of Insulin

2020 ◽  
Vol 26 (23) ◽  
pp. 5195-5199 ◽  
Author(s):  
Estelle Juère ◽  
Romain Caillard ◽  
Doris Marko ◽  
Giorgia Del Favero ◽  
Freddy Kleitz
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Oral Delivery ◽  
Mesoporous Silica Nanoparticles

Engineering Mesoporous Silica Nanoparticles for Improved Oral Delivery of Vancomycin

2021 ◽  
Author(s):  
John Ndayishimiye ◽  
Yuxue Cao ◽  
Tushar Kumeria ◽  
Mark Blaskovich ◽  
James Falconer ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Membrane Permeability ◽  
Oral Delivery ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Mesoporous Silica Nanoparticles ◽  
Methicillin Resistant

Vancomycin (Van) is a key antibiotic of choice for the treatment of systemic methicillin resistant Staphylococcus aureus (MRSA) infections. However, due to its poor membrane permeability, it is administered parenterally,...

scholarly journals Functionalized mesoporous silica nanoparticles for oral delivery of budesonide

2014 ◽  
Vol 211 ◽  
pp. 154-161 ◽  
Author(s):  
K. Yoncheva ◽  
M. Popova ◽  
A. Szegedi ◽  
J. Mihaly ◽  
B. Tzankov ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Oral Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Functionalized Mesoporous Silica

scholarly journals Effect of Shape on Mesoporous Silica Nanoparticles for Oral Delivery of Indomethacin

Pharmaceutics ◽  
2018 ◽  
Vol 11 (1) ◽  
pp. 4 ◽  
Author(s):  
Wei Zhang ◽  
Nan Zheng ◽  
Lu Chen ◽  
Luyao Xie ◽  
Mingshu Cui ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Small Angle ◽  
Oral Delivery ◽  
Oral Drug Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Oral Drug ◽  
Pharmacokinetic Studies

The use of mesoporous silica nanoparticles (MSNs) in the field of oral drug delivery has recently attracted greater attention. However, there is still limited knowledge about how the shape of MSNs affects drug delivery capacity. In our study, we fabricated mesoporous silica nanorods (MSNRs) to study the shape effects of MSNs on oral delivery. MSNRs were characterized by transmission electron microscopy (TEM), nitrogen adsorption/desorption, Fourier transform infrared spectroscopy (FTIR), and small-angle X-ray diffraction (small-angle XRD). Indomethacin (IMC), a non-steroidal anti-inflammatory agent, was loaded into MSNRs as model drug, and the drug-loaded MSNRs resulted in an excellent dissolution-enhancing effect. The cytotoxicity and in vivo pharmacokinetic studies indicated that MSNRs can be applied as a safe and efficient candidate for the delivery of insoluble drugs. The use of MSNs with a rod-like shape, as a drug delivery carrier, will extend the pharmaceutical applications of silica materials.

Lipid coated mesoporous silica nanoparticles as an oral delivery system for targeting and treatment of intravacuolar Salmonella infections

RSC Advances ◽  
2014 ◽  
Vol 4 (105) ◽  
pp. 61160-61166 ◽  
Author(s):  
Rajeev J. Mudakavi ◽  
Ashok M. Raichur ◽  
Dipshikha Chakravortty
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Delivery System ◽  
Oral Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Silica Nanoparticle ◽  
Mesoporous Silica Nanoparticle ◽  
Oral Delivery System ◽  
Salmonella Infections

Lipid coated mesoporous silica nanoparticle (L-MSN) were synthesized for oral delivery and targeting of ciprofloxacin for intracellular elimination ofSalmonellapathogen.

Recent Advances in Application of Azobenzenes Grafted on Mesoporous Silica Nanoparticles in Controlled Drug Delivery Systems Using Light as External Stimulus

2020 ◽  
Vol 20 (11) ◽  
pp. 1001-1016
Author(s):  
Sandra Ramírez-Rave ◽  
María Josefa Bernad-Bernad ◽  
Jesús Gracia-Mora ◽  
Anatoly K. Yatsimirsky
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
Delivery Systems ◽  
Surface Reactivity ◽  
External Stimulus ◽  
Recent Advances

Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is the use of external stimuli for drug release. In this context, light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and a large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last years with an emphasis on usually overlooked underlying chemistry, photophysical properties, and supramolecular complexation of azobenzenes.

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