scholarly journals Front Cover: Lithium–Bromide Exchange versus Nucleophilic Addition of Schiff's base: Unprecedented Tandem Cyclisation Pathways (Chem. Eur. J. 51/2019)

2019 ◽  
Vol 25 (51) ◽  
pp. 11792-11792
Author(s):  
Samantha A. Orr ◽  
Emily C. Border ◽  
Philip C. Andrews ◽  
Victoria L. Blair
Keyword(s):  
Nucleophilic Addition ◽  
Lithium Bromide ◽  
Schiff’S Base ◽  
Front Cover ◽  
J 51

scholarly journals Lithium–Bromide Exchange versus Nucleophilic Addition of Schiff's base: Unprecedented Tandem Cyclisation Pathways

2019 ◽  
Vol 25 (51) ◽  
pp. 11876-11882
Author(s):  
Samantha A. Orr ◽  
Emily C. Border ◽  
Philip C. Andrews ◽  
Victoria L. Blair
Keyword(s):  
Nucleophilic Addition ◽  
Lithium Bromide ◽  
Schiff’S Base

scholarly journals Lithium–Bromide Exchange versus Nucleophilic Addition of Schiff's Base: Unprecedented Tandem Cyclisation Pathways

2019 ◽  
Vol 25 (51) ◽  
pp. 11796-11796
Author(s):  
Samantha A. Orr ◽  
Emily C. Border ◽  
Philip C. Andrews ◽  
Victoria L. Blair
Keyword(s):  
Nucleophilic Addition ◽  
Lithium Bromide ◽  
Schiff’S Base

scholarly journals Front Cover: Fluoride-Catalyzed Nucleophilic Addition of PhSCF2 SiMe3 to Isatins: Synthesis of 3-(1′,1′-Difluoroalkyl)-3-hydroxyindolin-2-ones (Eur. J. Org. Chem. 3/2018)

2017 ◽  
Vol 2018 (3) ◽  
pp. 247-247
Author(s):  
Sirisuk Keereewan ◽  
Darunee Soorukram ◽  
Chutima Kuhakarn ◽  
Vichai Reutrakul ◽  
Manat Pohmakotr
Keyword(s):  
Nucleophilic Addition ◽  
Front Cover

scholarly journals Front Cover: Host-Guest Binding Hierarchy within Redox- and Luminescence-Responsive Supramolecular Self-Assembly Based on Chalcogenide Clusters and γ-Cyclodextrin (Chem. Eur. J. 51/2018)

2018 ◽  
Vol 24 (51) ◽  
pp. 13378-13378
Author(s):  
Anton A. Ivanov ◽  
Clément Falaise ◽  
Pavel A. Abramov ◽  
Michael A. Shestopalov ◽  
Kaplan Kirakci ◽  
...  
Keyword(s):  
Self Assembly ◽  
Front Cover ◽  
Chalcogenide Clusters ◽  
Guest Binding ◽  
J 51

scholarly journals Front Cover: Coordination Chemistry and Methylation of Mixed‐Substituted Tetraphosphetanes (RP−P t Bu) 2 (R=Ph, Py) (Chem. Eur. J. 51/2020)

2020 ◽  
Vol 26 (51) ◽  
pp. 11656-11656
Author(s):  
Robin Schoemaker ◽  
Philipp Kossatz ◽  
Kai Schwedtmann ◽  
Felix Hennersdorf ◽  
Jan J. Weigand
Keyword(s):  
Coordination Chemistry ◽  
Front Cover ◽  
J 51

Aldehyde gold clusters for molecular labeling

1995 ◽  
Vol 53 ◽  
pp. 858-859
Author(s):  
James F. Hainfeld ◽  
Frederic R. Furuya
Keyword(s):  
Covalent Bond ◽  
Aldehyde Group ◽  
Gold Clusters ◽  
Side Reactions ◽  
Amino Groups ◽  
Sodium Cyanoborohydride ◽  
Schiff’S Base ◽  
Protein Molecules ◽  
Hydroxysuccinimide Esters ◽  
Primary Amino

Glutaraldehyde is a useful tissue and molecular fixing reagents. The aldehyde moiety reacts mainly with primary amino groups to form a Schiff's base, which is reversible but reasonably stable at pH 7; a stable covalent bond may be formed by reduction with, e.g., sodium cyanoborohydride (Fig. 1). The bifunctional glutaraldehyde, (CHO-(CH2)3-CHO), successfully stabilizes protein molecules due to generally plentiful amines on their surface; bovine serum albumin has 60; 59 lysines + 1 α-amino. With some enzymes, catalytic activity after fixing is preserved; with respect to antigens, glutaraldehyde treatment can compromise their recognition by antibodies in some cases. Complicating the chemistry somewhat are the reported side reactions, where glutaraldehyde reacts with other amino acid side chains, cysteine, histidine, and tyrosine. It has also been reported that glutaraldehyde can polymerize in aqueous solution. Newer crosslinkers have been found that are more specific for the amino group, such as the N-hydroxysuccinimide esters, and are commonly preferred for forming conjugates. However, most of these linkers hydrolyze in solution, so that the activity is lost over several hours, whereas the aldehyde group is stable in solution, and may have an advantage of overall efficiency.

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