α‐Branched Ketone Dienolates: Base‐Catalysed Generation and Regio‐ and Enantioselective Addition Reactions

2019 ◽  
Vol 25 (41) ◽  
pp. 9701-9709 ◽  
Author(s):  
Iñaki Urruzuno ◽  
Odei Mugica ◽  
Giovanna Zanella ◽  
Silvia Vera ◽  
Enrique Gómez‐Bengoa ◽  
...  
Keyword(s):  
Addition Reactions ◽  
Enantioselective Addition

scholarly journals Enantioselective direct Mannich-type reactions of 2-benzylpyridine N-oxides catalyzed by chiral bis(guanidino)iminophosphorane organosuperbase

2018 ◽  
Vol 9 (18) ◽  
pp. 4348-4351 ◽  
Author(s):  
Qiupeng Hu ◽  
Azusa Kondoh ◽  
Masahiro Terada
Keyword(s):  
Base Catalysis ◽  
Addition Reactions ◽  
Brønsted Base ◽  
Enantioselective Addition ◽  
First Time

2-Benzylpyridine N-oxides possessing less acidic α-protons were utilized as pronucleophiles for the first time in enantioselective addition reactions under Brønsted base catalysis.

C3 Symmetric oxazolinyl ligand as catalyst in the enantioselective addition of diethylzinc to aldehydes

1997 ◽  
Vol 75 (6) ◽  
pp. 629-633 ◽  
Author(s):  
T.H. Chan ◽  
G.Z. Zheng
Keyword(s):  
Aromatic Aldehydes ◽  
Enantioselective Synthesis ◽  
Addition Reactions ◽  
Secondary Alcohols ◽  
Enantioselective Addition ◽  
Symmetric Ligands

The C3 symmetric oxazolinyl ligand 1 has been synthesized. Compound 1 catalyzed the addition of diethylzinc to aromatic aldehydes to give secondary alcohols with high enantiomeric excesses (up to 90%). Keywords: diethylzinc, enantioselective synthesis, C3 symmetric ligands, enantioselective addition reactions, oxazolinyl ligands.

Regio-, Stereo- and Enantioselective α-Addition of Carbonyl Nucleo-philes to Allenamides Catalyzed by a Synergistic Copper/Enamine System

2020 ◽  
Author(s):  
Rémi Blieck ◽  
Sebastien Lemouzy ◽  
Marc Taillefer ◽  
Florian Monnier
Keyword(s):  
Catalytic System ◽  
Secondary Amine ◽  
Primary Amine ◽  
Synergistic Catalysis ◽  
Enantioselective Addition ◽  
Amine Catalysts

A dual copper/enamine catalytic system is found to enable an intermolecular enantioselective α-addition of various carbonyl nucleophiles to allenamides. Secondary amine catalysts allowed the highly enantioselective addition of aldehydes, while using primary amine catalysts led to the enantioselective addition of ketoester nucleophiles. The process was found to be highly regio-, stereo- and enantio-selective and represented the first allene hydrofunctionalization using an synergistic catalysis involving copper

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