scholarly journals Front Cover: In Situ Enzyme Immobilization with Oxygen‐Sensitive Luminescent Metal–Organic Frameworks to Realize “All‐in‐One” Multifunctions (Chem. Eur. J. 21/2019)

2019 ◽  
Vol 25 (21) ◽  
pp. 5330-5330
Author(s):  
Yuzhi Xu ◽  
Si‐Yang Liu ◽  
Junling Liu ◽  
Li Zhang ◽  
Danping Chen ◽  
...  
Keyword(s):  
Enzyme Immobilization ◽  
Metal Organic Frameworks ◽  
Front Cover ◽  
Oxygen Sensitive ◽  
Metal Organic

scholarly journals In Situ Enzyme Immobilization with Oxygen‐Sensitive Luminescent Metal–Organic Frameworks to Realize “All‐in‐One” Multifunctions

2019 ◽  
Vol 25 (21) ◽  
pp. 5334-5334
Author(s):  
Yuzhi Xu ◽  
Si‐Yang Liu ◽  
Junling Liu ◽  
Li Zhang ◽  
Danping Chen ◽  
...  
Keyword(s):  
Enzyme Immobilization ◽  
Metal Organic Frameworks ◽  
Oxygen Sensitive ◽  
Metal Organic

In Situ Enzyme Immobilization with Oxygen‐Sensitive Luminescent Metal–Organic Frameworks to Realize “All‐in‐One” Multifunctions

2019 ◽  
Vol 25 (21) ◽  
pp. 5463-5471 ◽  
Author(s):  
Yuzhi Xu ◽  
Si‐Yang Liu ◽  
Junling Liu ◽  
Li Zhang ◽  
Danping Chen ◽  
...  
Keyword(s):  
Enzyme Immobilization ◽  
Metal Organic Frameworks ◽  
Oxygen Sensitive ◽  
Metal Organic

scholarly journals In situ X‐ray Diffraction Investigation of the Crystallisation of Perfluorinated Ce(IV)‐based Metal‐Organic Frameworks with UiO‐66 and MIL‐140 architectures

2021 ◽  
Author(s):  
Stephen J. I. Shearan ◽  
Jannick Jacobsen ◽  
Ferdinando Costantino ◽  
Roberto D’Amato ◽  
Dmitri Novikov ◽  
...  
Keyword(s):  
Metal Organic Frameworks ◽  
X Ray Diffraction ◽  
X Ray ◽  
Metal Organic

Silica Capsules Templated from Metal–Organic Frameworks for Enzyme Immobilization and Catalysis

Langmuir ◽  
2021 ◽  
Vol 37 (10) ◽  
pp. 3166-3172
Author(s):  
Xuebin Ma ◽  
Haiyan Sui ◽  
Qun Yu ◽  
Jiwei Cui ◽  
Jingcheng Hao
Keyword(s):  
Enzyme Immobilization ◽  
Metal Organic Frameworks ◽  
Metal Organic

scholarly journals Degradation Mechanism of Porous Metal-Organic Frameworks by In Situ Atomic Force Microscopy

Nanomaterials ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 722
Author(s):  
Ioanna Christodoulou ◽  
Tom Bourguignon ◽  
Xue Li ◽  
Gilles Patriarche ◽  
Christian Serre ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Degradation Mechanism ◽  
Metal Organic Frameworks ◽  
Porous Metal ◽  
Force Microscopy ◽  
Atomic Force ◽  
Metal Organic ◽  
The Media ◽  
Ph Conditions

In recent years, Metal-Organic Frameworks (MOFs) have attracted a growing interest for biomedical applications. The design of MOFs should take into consideration the subtle balance between stability and biodegradability. However, only few studies have focused on the MOFs’ stability in physiological media and their degradation mechanism. Here, we investigate the degradation of mesoporous iron (III) carboxylate MOFs, which are among the most employed MOFs for drug delivery, by a set of complementary methods. In situ AFM allowed monitoring with nanoscale resolution the morphological, dimensional, and mechanical properties of a series of MOFs in phosphate buffer saline and in real time. Depending on the synthetic route, the external surface presented either well-defined crystalline planes or initial defects, which influenced the degradation mechanism of the particles. Moreover, MOF stability was investigated under different pH conditions, from acidic to neutral. Interestingly, despite pronounced erosion, especially at neutral pH, the dimensions of the crystals were unchanged. It was revealed that the external surfaces of MOF crystals rapidly respond to in situ changes of the composition of the media they are in contact with. These observations are of a crucial importance for the design of nanosized MOFs for drug delivery applications.

Protein Immobilization in Metal–Organic Frameworks by Covalent Binding

2014 ◽  
Vol 67 (11) ◽  
pp. 1629 ◽  
Author(s):  
Xuan Wang ◽  
Trevor A. Makal ◽  
Hong-Cai Zhou
Keyword(s):  
Enzymatic Activity ◽  
Enzyme Immobilization ◽  
Working Conditions ◽  
Active Site ◽  
Covalent Binding ◽  
Metal Organic Frameworks ◽  
Protein Immobilization ◽  
Immobilization Of Enzymes ◽  
Metal Organic ◽  
Biological Catalysis

Metal–organic frameworks (MOFs), possessing a well defined system of pores, demonstrate extensive potential serving as a platform in biological catalysis. Successful immobilization of enzymes in a MOF system retains the enzymatic activity, renders the active site more accessible to the substrate, and promises recyclability for reuse, and solvent adaptability in a broad range of working conditions. This highlight describes enzyme immobilization on MOFs via covalent binding and its significance.

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