scholarly journals Synthesis and Biological Evaluation of the Novel Growth Inhibitor Streptol Glucoside, Isolated from an Obligate Plant Symbiont

2019 ◽  
Vol 25 (7) ◽  
pp. 1722-1726 ◽  
Author(s):  
Chien-Chi Hsiao ◽  
Simon Sieber ◽  
Antri Georgiou ◽  
Aurélien Bailly ◽  
Despina Emmanouilidou ◽  
...  
Keyword(s):  
Growth Inhibitor ◽  
Biological Evaluation ◽  
The Novel ◽  
Plant Symbiont ◽  
Synthesis And Biological Evaluation

Synthesis and biological evaluation of 4′-[(benzimidazol-1-yl) methyl]biphenyl-2-amides as dual angiotensin II and endothelin A receptor antagonists

MedChemComm ◽  
2015 ◽  
Vol 6 (8) ◽  
pp. 1479-1483 ◽  
Author(s):  
Xiao-Feng Han ◽  
Wei-Zhe Xue ◽  
Li-Ping Hao ◽  
Zhi-Ming Zhou
Keyword(s):  
Angiotensin Ii ◽  
Biological Evaluation ◽  
The Novel ◽  
Receptor Antagonists ◽  
Endothelin A Receptor ◽  
Endothelin A ◽  
Synthesis And Biological Evaluation ◽  
Amide Fragment

Discovery of new benzimidazoles as potent dual AT1 and ETA receptor antagonists with the novel N-(1H-tetrazol-5-yl)-amide fragment.

Novel 99mTc radiolabeled folate complexes with PEG linkers for FR-positive tumor imaging: synthesis and biological evaluation

RSC Advances ◽  
2014 ◽  
Vol 4 (61) ◽  
pp. 32197-32206 ◽  
Author(s):  
Fang Xie ◽  
Chun Zhang ◽  
Qian Yu ◽  
Yan Pang ◽  
Yuan Chen ◽  
...  
Keyword(s):  
Tumor Imaging ◽  
Folate Receptor ◽  
Biological Evaluation ◽  
Imaging Agent ◽  
The Novel ◽  
Novel Complex ◽  
Synthesis And Biological Evaluation ◽  
Tumor Imaging Agent

The novel complex 99mTc(FA-PEG2-HYNIC)(tricine/TPPTS) was clearly visualized at 120 min p.i. at the FR-positive tumor, highlighting its potential as an effective folate receptor tumor imaging agent.

The Novel Ketoprofen Amides - Synthesis and Biological Evaluation as Antioxidants, Lipoxygenase Inhibitors and Cytostatic Agents

2010 ◽  
Vol 75 (6) ◽  
pp. 641-652 ◽  
Author(s):  
Zrinka Rajić ◽  
Dimitra Hadjipavlou-Litina ◽  
Eleni Pontiki ◽  
Marijeta Kralj ◽  
Lidija Šuman ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
The Novel ◽  
Cytostatic Agents ◽  
Lipoxygenase Inhibitors ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis and biological Evaluation of Some Abbreviated New Triazolopyrimidines

2019 ◽  
pp. 354-361
Author(s):  
Jatin Vora ◽  
Kartik Vyas
Keyword(s):  
Biginelli Reaction ◽  
Biological Evaluation ◽  
Spectroscopic Techniques ◽  
The Novel ◽  
Antibacterial And Antifungal Activity ◽  
1H Nuclear Magnetic Resonance ◽  
Elemental Analyses ◽  
Antibacterial And Antifungal ◽  
Synthesis And Biological Evaluation ◽  
Compound Series

A cogent synthesis of completely new compound series of by 6-(3,5-bis(trifluoromethyl)phenyl)-4-(4-chlorophenyl)-3,4-dihydro pyrimidine-2(1H)-one (Biginelli reaction) was achieved by continue heating of (E)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(substituted phenyl)prop-2-en-1-one and urea for 5 hours with 40% KOH and ethyl alcohol. (E)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(substituted phenyl)prop-2-en-1-one is produced by Claisen-Schmidt Condensation. In this condensation 1-(3,5-bis(trifluoromethyl)phenyl)ethanone and different aldehyde are mixed. All the novel compound series were characterized by infrared and 1H nuclear magnetic resonance and mass spectroscopic techniques and by elemental analyses. The newly synthesized compounds were evaluated for their antibacterial and antifungal activity

Design, Synthesis and Biological Evaluation of the Novel Antitumor Agent Aurone Derivatives

2013 ◽  
Vol 781-784 ◽  
pp. 1235-1239
Author(s):  
Qian Nan Guo ◽  
Lei Lv ◽  
Yao Zhou ◽  
Peng Yu ◽  
Yuou Teng
Keyword(s):  
Biological Activities ◽  
Antitumor Agent ◽  
Biological Evaluation ◽  
The Novel ◽  
Pharmacological Activities ◽  
Design Synthesis ◽  
H Nmr ◽  
Wide Range ◽  
Inhibitory Activities ◽  
Synthesis And Biological Evaluation

Aurones belong to a class of heterocyclic flavonoids which contains a benzofuran element associated with a benzylidene linked in position 2. Aurones possess a wide range of pharmacological activities and biological activities, such as antitumor, antifungal, phytoalexin and so on. A novel series of 2-ayl-yl (5-methacrylate) aurone analogues were synthesized in six steps with the overall yield of 11%-13% and characterized by 1H NMR. Among the key intermediates and target compounds, 2-(2-furan-ylmethylene)-5-methacrylate-benzofuran-3(2H)-one (7a) and 2-(2-thienyl-ylmethylene)-5-methacrylate-benzofuran-3(2H)-one (7b) have never been reported before. Primary biological activities evaluation showed that 7a exhibited good inhibitory activities against K562 with an IC50 of 2.18 μM and against HepG2 with an IC50 of 3.95μM.

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