scholarly journals High Throughput Experimentation and Continuous Flow Validation of Suzuki-Miyaura Cross-Coupling Reactions

2018 ◽  
Vol 24 (38) ◽  
pp. 9546-9554 ◽  
Author(s):  
Zinia Jaman ◽  
Ahmed Mufti ◽  
Samyukta Sah ◽  
Larisa Avramova ◽  
David H. Thompson
Keyword(s):  
High Throughput ◽  
Continuous Flow ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Cross Coupling Reactions ◽  
High Throughput Experimentation

Recent Applications of Continuous Flow in Homogeneous Palladium Catalysis

Synthesis ◽  
2020 ◽  
Vol 52 (23) ◽  
pp. 3511-3529 ◽  
Author(s):  
Peter Koóš ◽  
Martin Markovič ◽  
Pavol Lopatka ◽  
Tibor Gracza
Keyword(s):  
Organic Synthesis ◽  
Continuous Flow ◽  
Palladium Catalysis ◽  
Flow Chemistry ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Flow Conditions ◽  
Cross Coupling Reactions ◽  
Continuous Flow Chemistry ◽  
Oxidative Transformations

Considerable advances have been made using continuous flow chemistry as an enabling tool in organic synthesis. Consequently, the number of articles reporting continuous flow methods has increased significantly in recent years. This review covers the progress achieved in homogeneous palladium catalysis using continuous flow conditions over the last five years, including C–C/C–N cross-coupling reactions, carbonylations and reductive/oxidative transformations.1 Introduction2 C–C Cross-Coupling Reactions3 C–N Coupling Reactions4 Carbonylation Reactions5 Miscellaneous Reactions6 Key to Schematic Symbols7 Conclusion

scholarly journals Cover Picture: Dendrimer-Encapsulated Palladium Nanoparticles for Continuous-Flow Suzuki-Miyaura Cross-Coupling Reactions (ChemCatChem 6/2015)

ChemCatChem ◽  
2015 ◽  
Vol 7 (6) ◽  
pp. 875-875
Author(s):  
Roberto Ricciardi ◽  
Jurriaan Huskens ◽  
Michael Holtkamp ◽  
Uwe Karst ◽  
Willem Verboom
Keyword(s):  
Palladium Nanoparticles ◽  
Continuous Flow ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Cross Coupling Reactions

Nanomole-scale high-throughput chemistry for the synthesis of complex molecules

Science ◽  
2014 ◽  
Vol 347 (6217) ◽  
pp. 49-53 ◽  
Author(s):  
Alexander Buitrago Santanilla ◽  
Erik L. Regalado ◽  
Tony Pereira ◽  
Michael Shevlin ◽  
Kevin Bateman ◽  
...  
Keyword(s):  
High Throughput ◽  
Scale Up ◽  
Natural Product Synthesis ◽  
Test Case ◽  
Coupling Reactions ◽  
High Throughput Analysis ◽  
Complex Molecules ◽  
Cross Coupling Reactions ◽  
High Throughput Experimentation ◽  
Palladium Catalyzed

At the forefront of new synthetic endeavors, such as drug discovery or natural product synthesis, large quantities of material are rarely available and timelines are tight. A miniaturized automation platform enabling high-throughput experimentation for synthetic route scouting to identify conditions for preparative reaction scale-up would be a transformative advance. Because automated, miniaturized chemistry is difficult to carry out in the presence of solids or volatile organic solvents, most of the synthetic “toolkit” cannot be readily miniaturized. Using palladium-catalyzed cross-coupling reactions as a test case, we developed automation-friendly reactions to run in dimethyl sulfoxide at room temperature. This advance enabled us to couple the robotics used in biotechnology with emerging mass spectrometry–based high-throughput analysis techniques. More than 1500 chemistry experiments were carried out in less than a day, using as little as 0.02 milligrams of material per reaction.

Sandwich Immunoassay as a High-Throughput Screening Method for Cross-Coupling Reactions

2005 ◽  
Vol 117 (42) ◽  
pp. 7023-7026 ◽  
Author(s):  
Paola Vicennati ◽  
Nicolas Bensel ◽  
Alain Wagner ◽  
Christophe Créminon ◽  
Frédéric Taran
Keyword(s):  
High Throughput ◽  
High Throughput Screening ◽  
Screening Method ◽  
Cross Coupling ◽  
Sandwich Immunoassay ◽  
Coupling Reactions ◽  
Cross Coupling Reactions

Sandwich Immunoassay as a High-Throughput Screening Method for Cross-Coupling Reactions

2005 ◽  
Vol 44 (42) ◽  
pp. 6863-6866 ◽  
Author(s):  
Paola Vicennati ◽  
Nicolas Bensel ◽  
Alain Wagner ◽  
Christophe Créminon ◽  
Frédéric Taran
Keyword(s):  
High Throughput ◽  
High Throughput Screening ◽  
Screening Method ◽  
Cross Coupling ◽  
Sandwich Immunoassay ◽  
Coupling Reactions ◽  
Cross Coupling Reactions

Dendrimer-encapsulated Pd nanoparticles as catalysts for C–C cross-couplings in flow microreactors

2015 ◽  
Vol 13 (17) ◽  
pp. 4953-4959 ◽  
Author(s):  
Roberto Ricciardi ◽  
Jurriaan Huskens ◽  
Willem Verboom
Keyword(s):  
Continuous Flow ◽  
Cross Coupling ◽  
Pd Nanoparticles ◽  
Catalytic Performance ◽  
Coupling Reactions ◽  
Cross Coupling Reactions ◽  
Flow Microreactors

Dendrimer-encapsulated Pd nanoparticles anchored within continuous flow microreactors are efficient for C–C cross-coupling reactions. This is witnessed by the good catalytic performance for the Heck–Cassar and Suzuki–Miyaura couplings.

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