Transition Metal Ions Promote the Bioavailability of Hydrophobic Therapeutics: Cu and Zn Interactions with RNA Polymerase I Inhibitor CX5461

2018 ◽  
Vol 24 (24) ◽  
pp. 6334-6338 ◽  
Author(s):  
Kathleen E. Prosser ◽  
Ada W. Y. Leung ◽  
Shane Harrypersad ◽  
Andrew R. Lewis ◽  
Marcel B. Bally ◽  
...  
Keyword(s):  
Transition Metal ◽  
Rna Polymerase ◽  
Metal Ions ◽  
Transition Metal Ions ◽  
Rna Polymerase I ◽  
Polymerase I ◽  
Cu And Zn

Reactivity of Hydrated Monovalent First Row Transition Metal Ions [M(H2O)n]+, M = Cr, Mn, Fe, Co, Ni, Cu, and Zn, n < 50, Toward Acetonitrile

2015 ◽  
Vol 119 (22) ◽  
pp. 5566-5578 ◽  
Author(s):  
Ina Herber ◽  
Wai-Kit Tang ◽  
Ho-Yin Wong ◽  
Tim-Wai Lam ◽  
Chi-Kit Siu ◽  
...  
Keyword(s):  
Transition Metal ◽  
Metal Ions ◽  
Transition Metal Ions ◽  
Cu And Zn

Reactions of Hydrated Singly Charged First-Row Transition-Metal Ions M+(H2O)n(M=V, Cr, Mn, Fe, Co, Ni, Cu, and Zn) toward Nitric Oxide in the Gas Phase

2013 ◽  
Vol 19 (11) ◽  
pp. 3741-3750 ◽  
Author(s):  
Christian van der Linde ◽  
Robert F. Höckendorf ◽  
O. Petru Balaj ◽  
Martin K. Beyer
Keyword(s):  
Nitric Oxide ◽  
Transition Metal ◽  
Metal Ions ◽  
Gas Phase ◽  
Transition Metal Ions ◽  
Singly Charged ◽  
Cu And Zn

Cu and Zn interactions with Aβ peptides: consequence of coordination on aggregation and formation of neurotoxic soluble Aβ oligomers

Metallomics ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 64-84 ◽  
Author(s):  
Monika Rana ◽  
Anuj Kumar Sharma
Keyword(s):  
Alzheimer’S Disease ◽  
Coordination Chemistry ◽  
Transition Metal ◽  
Metal Ions ◽  
Amyloid Β ◽  
Transition Metal Ions ◽  
Aβ Oligomers ◽  
Aβ Peptides ◽  
Soluble Aβ Oligomers ◽  
Cu And Zn

The coordination chemistry of transition metal ions (Fe, Cu, Zn) with the amyloid-β (Aβ) peptides has attracted a lot of attention in recent years due to its repercussions in Alzheimer's disease (AD).

HREM Study of electron-induced surface radiation damage in ReO3

1991 ◽  
Vol 49 ◽  
pp. 636-637
Author(s):  
R. Ai ◽  
H.-J. Fan ◽  
L. D. Marks
Keyword(s):  
Transition Metal ◽  
Metal Ions ◽  
Metal Oxides ◽  
Electron Irradiation ◽  
Transition Metal Oxides ◽  
Carbon Film ◽  
Transition Metal Ions ◽  
Surface Radiation ◽  
Valence Transition ◽  
Electron Microscopes

It has been known for a long time that electron irradiation induces damage in maximal valence transition metal oxides such as TiO2, V2O5, and WO3, of which transition metal ions have an empty d-shell. This type of damage is excited by electronic transition and can be explained by the Knoteck-Feibelman mechanism (K-F mechanism). Although the K-F mechanism predicts that no damage should occur in transition metal oxides of which the transition metal ions have a partially filled d-shell, namely submaximal valence transition metal oxides, our recent study on ReO3 shows that submaximal valence transition metal oxides undergo damage during electron irradiation.ReO3 has a nearly cubic structure and contains a single unit in its cell: a = 3.73 Å, and α = 89°34'. TEM specimens were prepared by depositing dry powders onto a holey carbon film supported on a copper grid. Specimens were examined in Hitachi H-9000 and UHV H-9000 electron microscopes both operated at 300 keV accelerating voltage. The electron beam flux was maintained at about 10 A/cm2 during the observation.

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