Preparation of Robust Metal-Free Magnetic Nanoemulsions Encapsulating Low-Molecular-Weight Nitroxide Radicals and Hydrophobic Drugs Directed Toward MRI-Visible Targeted Delivery

2017 ◽  
Vol 23 (62) ◽  
pp. 15713-15720 ◽  
Author(s):  
Kota Nagura ◽  
Yusa Takemoto ◽  
Satori Moronaga ◽  
Yoshiaki Uchida ◽  
Satoshi Shimono ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Targeted Delivery ◽  
Low Molecular Weight ◽  
Hydrophobic Drugs ◽  
Nitroxide Radicals ◽  
Metal Free

scholarly journals Metal- and Oxidant-Free Photoinduced Aromatic Trifluoromethylation Performed in Aerated Gel Media: Determining the Effects on Yield and Selectivity

Molecules ◽  
2018 ◽  
Vol 24 (1) ◽  
pp. 29 ◽  
Author(s):  
Alex Abramov ◽  
Hendrik Vernickel ◽  
César Saldías ◽  
David Díaz Díaz
Keyword(s):  
Molecular Weight ◽  
Room Temperature ◽  
Homogeneous Solution ◽  
Product Distribution ◽  
Blocking Effect ◽  
Low Molecular Weight ◽  
Metal Free ◽  
Potential Benefits ◽  
Media Concentration ◽  
Reaction Media

In this work we have investigated the potential benefits of using supramolecular gel networks as reaction media to carry out air-sensitive metal-free light-induced trifluoromethylation of six-membered (hetero)arenes under aerobic conditions. This reaction was performed at room temperature (RT) using sodium triflinate (CF3SO2Na, Langlois’ reagent) as a source of radicals and diacetyl as electron donor. The effects of confinement in gel media, concentration of reactants, and type of light source on yield and product distribution were evaluated and compared to the results obtained in homogeneous solution. Four different low molecular weight (LMW) gelators were employed in this study. The results confirmed the blocking effect of the gel medium against reaction quenching by external oxygen, as well as a certain control on the kinetics and selectivity.

scholarly journals Reversible Masking Using Low-Molecular-Weight Neutral Lipids to Achieve Optimal-Targeted Delivery

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Nancy Smyth Templeton ◽  
Neil Senzer
Keyword(s):  
Molecular Weight ◽  
Targeted Delivery ◽  
Neutral Lipids ◽  
Metastatic Cancer ◽  
Target Cells ◽  
Low Molecular Weight ◽  
Specific Cell ◽  
Surface Receptors ◽  
Normal Tissues ◽  
Delivery Vehicles

Intravenous injection of therapeutics is required to effectively treat or cure metastatic cancer, certain cardiovascular diseases, and other acquired or inherited diseases. Using this route of delivery allows potential uptake in all disease targets that are accessed by the bloodstream. However, normal tissues and organs also have the potential for uptake of therapeutic agents. Therefore, investigators have used targeted delivery to attempt delivery solely to the target cells; however, use of ligands on the surface of delivery vehicles to target specific cell surface receptors is not sufficient to avoid nonspecific uptake. PEGylation has been used for decades to try to avoid nonspecific uptake but suffers from many problems known as “The PEGylation Dilemma.” We have solved this dilemma by replacing PEGylation with reversible masking using low-molecular-weight neutral lipids in order to achieve optimal-targeted delivery solely to target cells. Our paper will focus on this topic.

scholarly journals A novel metal-free low molecular weight superoxide dismutase mimic.

1988 ◽  
Vol 263 (34) ◽  
pp. 17921-17924
Author(s):  
A Samuni ◽  
C M Krishna ◽  
P Riesz ◽  
E Finkelstein ◽  
A Russo
Keyword(s):  
Molecular Weight ◽  
Superoxide Dismutase ◽  
Low Molecular Weight ◽  
Metal Free ◽  
Superoxide Dismutase Mimic

A high-performance oil-free backing pump for electron microscopes

1978 ◽  
Vol 36 (1) ◽  
pp. 110-111
Author(s):  
G.K.W. Balkau ◽  
E. Bez ◽  
J.L. Farrant
Keyword(s):  
Molecular Weight ◽  
Electron Microscope ◽  
Hot Spots ◽  
High Performance ◽  
Carbonaceous Material ◽  
Contamination Rate ◽  
Low Molecular Weight ◽  
Principal Source ◽  
Rotary Pumps ◽  
Electron Microscopes

The earliest account of the contamination of electron microscope specimens by the deposition of carbonaceous material during electron irradiation was published in 1947 by Watson who was then working in Canada. It was soon established that this carbonaceous material is formed from organic vapours, and it is now recognized that the principal source is the oil-sealed rotary pumps which provide the backing vacuum. It has been shown that the organic vapours consist of low molecular weight fragments of oil molecules which have been degraded at hot spots produced by friction between the vanes and the surfaces on which they slide. As satisfactory oil-free pumps are unavailable, it is standard electron microscope practice to reduce the partial pressure of organic vapours in the microscope in the vicinity of the specimen by using liquid-nitrogen cooled anti-contamination devices. Traps of this type are sufficient to reduce the contamination rate to about 0.1 Å per min, which is tolerable for many investigations.

Low-molecular-weight heparin in the prevention and treatment of thromboembolic disorders

1998 ◽  
Vol 1 (5) ◽  
pp. 166-174 ◽  
Author(s):  
Evelyn R Hermes De Santis ◽  
Betsy S Laumeister ◽  
Vidhu Bansal ◽  
Vandana Kataria ◽  
Preeti Loomba ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight Heparin ◽  
Low Molecular Weight ◽  
Prevention And Treatment
Sign in / Sign up

Export Citation Format

Share Document