Weak Supramolecular Interactions Governing Parallel and Antiparallel DNA Quadruplexes: Insights from Large‐Scale Quantum Mechanics Analysis of Experimentally Derived Models

2017 ◽  
Vol 23 (23) ◽  
pp. 5573-5584 ◽  
Author(s):  
Yevgen P. Yurenko ◽  
Jan Novotný ◽  
Radek Marek
Author(s):  
Bhanu Chander

Quantum cryptography is actions to protect transactions through executing the circumstance of quantum physics. Up-to-the-minute cryptography builds security over the primitive ability of fragmenting enormous numbers into relevant primes; however, it features inconvenience with ever-increasing machine computing power along with current mathematical evolution. Among all the disputes, key distribution is the most important trouble in classical cryptography. Quantum cryptography endows with clandestine communication by means of offering a definitive protection statement with the rule of the atmosphere. Exploit quantum mechanics to cryptography can be enlarging unrestricted, unfailing information transmission. This chapter describes the contemporary state of classical cryptography along with the fundamentals of quantum cryptography, quantum protocol key distribution, implementation criteria, quantum protocol suite, quantum resistant cryptography, and large-scale quantum key challenges.


Universe ◽  
2019 ◽  
Vol 5 (4) ◽  
pp. 92 ◽  
Author(s):  
Jérôme Martin

According to the theory of cosmic inflation, the large scale structures observed in our Universe (galaxies, clusters of galaxies, Cosmic Background Microwave—CMB—anisotropy...) are of quantum mechanical origin. They are nothing but vacuum fluctuations, stretched to cosmological scales by the cosmic expansion and amplified by gravitational instability. At the end of inflation, these perturbations are placed in a two-mode squeezed state with the strongest squeezing ever produced in Nature (much larger than anything that can be made in the laboratory on Earth). This article studies whether astrophysical observations could unambiguously reveal this quantum origin by borrowing ideas from quantum information theory. It is argued that some of the tools needed to carry out this task have been discussed long ago by J. Bell in a, so far, largely unrecognized contribution. A detailled study of his paper and of the criticisms that have been put forward against his work is presented. Although J. Bell could not have realized it when he wrote his letter since the quantum state of cosmological perturbations was not yet fully characterized at that time, it is also shown that Cosmology and cosmic inflation represent the most interesting frameworks to apply the concepts he investigated. This confirms that cosmic inflation is not only a successful paradigm to understand the early Universe. It is also the only situation in Physics where one crucially needs General Relativity and Quantum Mechanics to derive the predictions of a theory and, where, at the same time, we have high-accuracy data to test these predictions, making inflation a playground of utmost importance to discuss foundational issues in Quantum Mechanics.


Author(s):  
Kaworu Yodo ◽  
Hiroshi Kawai ◽  
Hiroshi Okada ◽  
Masao Ogino ◽  
Ryuji Shioya

Fracture mechanics analysis using the finite element method has been one of the key methodologies to evaluate structural integrity for aging infrastructures such as aircraft, ship, power plants, etc. However, three-dimensional crack analyses for structures with highly complex three-dimensional shapes have not widely been used, because of many technical difficulties such as the lack of enough computational power. The authors have been developing a fracture mechanics analysis system that can deal with arbitrary shaped cracks in three-dimensional structures. The system consists of mesh generation software, a finite element analysis program and a fracture mechanics module. In our system, a Virtual Crack Closure-Integral Method (VCCM) for the quadratic tetrahedral finite elements is adopted to evaluate the stress intensity factors. This system can perform the three-dimensional fracture analyses. Fatigue and SCC crack propagation analyses with more than one cracks of arbitrary complicated shapes and orientations. The rate and direction of crack propagation are predicted by using appropriate formulae based on the stress intensity factors. When the fracture mechanics analysis system is applied to the complex shaped aging structures with the cracks which are modeled explicitly, the size of finite element analysis tends to be very large. Therefore, a large scale parallel structural analysis code is required. We also have been developing an open-source CAE system, ADVENTURE. It is based on the hierarchical domain decomposition method (HDDM) with the balancing domain decomposition (BDD) pre-conditioner. A general-purpose parallel structural analysis solver, ADVENTURE_Solid is one of the solver modules of the ADVENTURE system. In this paper, we combined VCCM for the tetrahedral finite element with ADVENTURE system and large-scale fracture analyses are fully automated. They are performed using the massively parallel super computer ES2 (Earth Simulator 2) which is owned and run by JAMSTEC (Japan Agency for Marine-Earth Science and Technology).


1992 ◽  
Vol 01 (01) ◽  
pp. 145-160 ◽  
Author(s):  
Y. JACK NG

The cosmological constant is a macroscopic parameter which controls the large-scale structure of the Universe. All observations to date have shown that it is very small. However, our modern microscopic theory of particle physics and gravity suggests that the cosmological constant should be very large. This discrepancy between theoretical expectation and empirical observation constitutes the cosmological constant problem. After a review of the problem, some approaches to its solution are briefly discussed, and then a possible solution is proposed. In this approach, the cosmological constant appears as a constant of integration, unrelated to any parameters in the Lagrangian. The solution makes crucial use of quantum mechanics.


2015 ◽  
Vol 8 (1) ◽  
pp. 16 ◽  
Author(s):  
Anna C.M. Backerra

<p class="1Body">Small-scale physics called quantum mechanics, is still incompatible with large-scale physics as developed by Einstein in his general relativity theory. By using twin physics, which is a dualistic way of considering the universe, and following Einstein’s later advice it is possible to create a bridge between these extremes. The formulation is carried out using complementary language in which time and space necessarily occur as two distinct qualities, although they are treated analogously. The basic item in the theory is the Heisenberg unit, which has a constant amount of potential energy, and which is supplied with mathematical attributes; by interaction with another Heisenberg unit, these attributes are transformed into physical qualities. With this theory, a photon can be described such that its velocity is constant without using the related postulate, showing how the speed of light is the link between small- and large-scale physics. The Planck constant emerges from the explanation. The photon is accompanied by a so-called anti-photon, being a charged, massless particle, traveling with the same velocity and exchanging electromagnetic energy.</p>


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