Near-Infrared Light and pH Dual-Responsive Targeted Drug Carrier Based on Core-Crosslinked Polyaniline Nanoparticles for Intracellular Delivery of Cisplatin

2017 ◽  
Vol 23 (22) ◽  
pp. 5352-5360 ◽  
Author(s):  
Chaoqun You ◽  
Hongshuai Wu ◽  
Minxing Wang ◽  
Yawen Zhang ◽  
Jingwen Wang ◽  
...  
Keyword(s):  
Near Infrared ◽  
Drug Carrier ◽  
Intracellular Delivery ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Dual Responsive ◽  
Polyaniline Nanoparticles ◽  
Targeted Drug

scholarly journals Drug Delivery: Near-Infrared Light-Triggered, Targeted Drug Delivery to Cancer Cells by Aptamer Gated Nanovehicles (Adv. Mater. 21/2012)

2012 ◽  
Vol 24 (21) ◽  
pp. 2798-2798
Author(s):  
Xinjian Yang ◽  
Xia Liu ◽  
Zhen Liu ◽  
Fang Pu ◽  
Jinsong Ren ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Targeted Drug Delivery ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Targeted Drug

scholarly journals Near-infrared light and tumor microenvironment dual responsive size-switchable nanocapsules for multimodal tumor theranostics

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Zhiyi Wang ◽  
Yanmin Ju ◽  
Zeeshan Ali ◽  
Hui Yin ◽  
Fugeng Sheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Microenvironment ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
In Vivo Experiments ◽  
Dual Responsive ◽  
Synthetic Strategy ◽  
Scientific Challenge

Abstract Smart drug delivery systems (SDDSs) for cancer treatment are of considerable interest in the field of theranostics. However, developing SDDSs with early diagnostic capability, enhanced drug delivery and efficient biodegradability still remains a scientific challenge. Herein, we report near-infrared light and tumor microenvironment (TME), dual responsive as well as size-switchable nanocapsules. These nanocapsules are made of a PLGA-polymer matrix coated with Fe/FeO core-shell nanocrystals and co-loaded with chemotherapy drug and photothermal agent. Smartly engineered nanocapsules can not only shrink and decompose into small-sized nanodrugs upon drug release but also can regulate the TME to overproduce reactive oxygen species for enhanced synergistic therapy in tumors. In vivo experiments demonstrate that these nanocapsules can target to tumor sites through fluorescence/magnetic resonance imaging and offer remarkable therapeutic results. Our synthetic strategy provides a platform for next generation smart nanocapsules with enhanced permeability and retention effect, multimodal anticancer theranostics, and biodegradability.

scholarly journals Near-Infrared Light-Responsive Core–Shell Nanogels for Targeted Drug Delivery

ACS Nano ◽  
2011 ◽  
Vol 5 (6) ◽  
pp. 5094-5099 ◽  
Author(s):  
Huaizhi Kang ◽  
Anna Carolina Trondoli ◽  
Guizhi Zhu ◽  
Yan Chen ◽  
Ya-Jen Chang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Near Infrared ◽  
Infrared Light ◽  
Core Shell ◽  
Near Infrared Light ◽  
Targeted Drug

Cisplatin and Ce6 loaded polyaniline nanoparticles: An efficient near-infrared light mediated synergistic therapeutic agent

2019 ◽  
Vol 95 ◽  
pp. 183-191 ◽  
Author(s):  
Chaoqun You ◽  
Zhiguo Gao ◽  
Mingxin Wang ◽  
Hongshuai Wu ◽  
Peijing An ◽  
...  
Keyword(s):  
Near Infrared ◽  
Therapeutic Agent ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Polyaniline Nanoparticles

Aptamer-guided upconversion nanoplatform for targeted drug delivery and near-infrared light-triggered photodynamic therapy

2019 ◽  
Vol 34 (6) ◽  
pp. 875-888 ◽  
Author(s):  
Hui-Chao Lin ◽  
Wen-Tian Li ◽  
Thushara W Madanayake ◽  
Can Tao ◽  
Qiang Niu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Targeted Drug Delivery ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Targeted Drug
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