Dynamic Kinetic Resolution Approach for the Asymmetric Synthesis of Tetrahydrobenzodiazepines Using Transfer Hydrogenation by Chiral Phosphoric Acid

2016 ◽  
Vol 22 (24) ◽  
pp. 8078-8083 ◽  
Author(s):  
Kosaku Horiguchi ◽  
Eri Yamamoto ◽  
Kodai Saito ◽  
Masahiro Yamanaka ◽  
Takahiko Akiyama
Keyword(s):  
Phosphoric Acid ◽  
Asymmetric Synthesis ◽  
Kinetic Resolution ◽  
Transfer Hydrogenation ◽  
Dynamic Kinetic Resolution ◽  
Chiral Phosphoric Acid

Facile construction of three contiguous stereogenic centers via dynamic kinetic resolution in asymmetric transfer hydrogenation of quinolines

2014 ◽  
Vol 50 (83) ◽  
pp. 12526-12529 ◽  
Author(s):  
Mu-Wang Chen ◽  
Xian-Feng Cai ◽  
Zhang-Pei Chen ◽  
Lei Shi ◽  
Yong-Gui Zhou
Keyword(s):  
Phosphoric Acid ◽  
Kinetic Resolution ◽  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation ◽  
Dynamic Kinetic Resolution ◽  
Resolution Process ◽  
Chiral Phosphoric Acid ◽  
Stereogenic Centers ◽  
Facile Route

An efficient and facile route to chiral tetrahydroquinolines with three contiguous stereogenic centers via a dynamic kinetic resolution process has been successfully developed by using chiral phosphoric acid as catalyst and Hantzsch ester as the hydrogen source with up to 89% ee.

A new cost-effective Ru-chloramphenicol base derivative catalyst for the asymmetric transfer hydrogenation/dynamic kinetic resolution of N-Boc α-amino-β-ketoesters and its application to the synthesis of the chiral core of vancomycin

RSC Advances ◽  
2016 ◽  
Vol 6 (44) ◽  
pp. 37701-37709 ◽  
Author(s):  
Xinlong Wang ◽  
Lingjun Xu ◽  
Fangjun Xiong ◽  
Yan Wu ◽  
Fener Chen
Keyword(s):  
Asymmetric Synthesis ◽  
Kinetic Resolution ◽  
Cost Effective ◽  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation ◽  
Dynamic Kinetic Resolution ◽  
Amino Esters ◽  
Base Derivative

Herein we describe the application of Ru-chloramphenicol base complexes catalyzed highly diastereo- and enantioselective transfer hydrogenation of N-Boc α-amino-β-ketoesters for the asymmetric synthesis of anti-N-Boc-β-hydroxy-α-amino esters.

Origin of Enantioselectivity in Chiral Phosphoric-Acid-Catalyzed Azlactone Dynamic Kinetic Resolution

2021 ◽  
Vol 86 (18) ◽  
pp. 13169-13174
Author(s):  
Pedro P. De Castro ◽  
Gabriel M. F. Batista ◽  
Giovanni W. Amarante ◽  
Hélio F. Dos Santos
Keyword(s):  
Phosphoric Acid ◽  
Kinetic Resolution ◽  
Dynamic Kinetic Resolution ◽  
Chiral Phosphoric Acid ◽  
Acid Catalyzed

Chiral Phosphoric Acid Catalyzed Asymmetric Ugi Reaction by Dynamic Kinetic Resolution of the Primary Multicomponent Adduct

2016 ◽  
Vol 128 (17) ◽  
pp. 5368-5371 ◽  
Author(s):  
Yun Zhang ◽  
Yu-Fei Ao ◽  
Zhi-Tang Huang ◽  
De-Xian Wang ◽  
Mei-Xiang Wang ◽  
...  
Keyword(s):  
Phosphoric Acid ◽  
Kinetic Resolution ◽  
Ugi Reaction ◽  
Dynamic Kinetic Resolution ◽  
Chiral Phosphoric Acid ◽  
Acid Catalyzed
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