Asymmetric, Three-Component, One-Pot Synthesis of Spiropyrazolones and 2,5-Chromenediones from Aldol Condensation/NHC-Catalyzed Annulation Reactions

2016 ◽  
Vol 22 (15) ◽  
pp. 5123-5127 ◽  
Author(s):  
Lei Wang ◽  
Sun Li ◽  
Pankaj Chauhan ◽  
Daniel Hack ◽  
Arne R. Philipps ◽  
...  
Keyword(s):  
Aldol Condensation ◽  
One Pot ◽  
One Pot Synthesis

Catalyst-Free One-Pot Synthesis of Novel Heteroarylamine Substituted Furo[3,2-c]coumarins

Synlett ◽  
2018 ◽  
Vol 29 (12) ◽  
pp. 1589-1592 ◽  
Author(s):  
Abolfazl Olyaei ◽  
Mahnaz Saraei ◽  
Reyhaneh Khoeiniha
Keyword(s):  
Michael Addition ◽  
Aldol Condensation ◽  
Ring Closure ◽  
Dehydration Reaction ◽  
One Pot ◽  
Catalyst Free ◽  
One Pot Synthesis ◽  
Tandem Process ◽  
First Time

A high-yielding cyclocondensation of 4-hydroxycoumarin, phenylglyoxal monohydrate, and heteroarylamines proceeds without catalysis, which gives novel functionalized furo[3,2-c]coumarins and heteroarylamino alkylation of coumarin products in acetonitrile under reflux, is reported for the first time. This tandem process involves sequentially an aldol condensation, Michael addition, a ring closure, and dehydration reaction.

A new aldol condensation of .alpha.-allenic esters with aldehydes, including a one-pot synthesis of enyne compounds

1993 ◽  
Vol 58 (22) ◽  
pp. 5952-5957 ◽  
Author(s):  
Sadao Tsuboi ◽  
Hirofumi Kuroda ◽  
Satoshi Takatsuka ◽  
Takashi Fukawa ◽  
Takashi Sakai ◽  
...  
Keyword(s):  
Aldol Condensation ◽  
One Pot ◽  
One Pot Synthesis ◽  
Allenic Esters

Direct One-Pot Synthesis of Phenanthrenes via Suzuki−Miyaura Coupling/Aldol Condensation Cascade Reaction

2008 ◽  
Vol 73 (2) ◽  
pp. 495-501 ◽  
Author(s):  
Young Ha Kim ◽  
Hyuk Lee ◽  
Yeong Joon Kim ◽  
Bum Tae Kim ◽  
Jung-Nyoung Heo
Keyword(s):  
Aldol Condensation ◽  
Cascade Reaction ◽  
One Pot ◽  
One Pot Synthesis

In-Situ Synthesis of Active Pharmaceutical Ingredients Which Content Pyrazole Skeleton

2020 ◽  
Vol 17 (10) ◽  
pp. 743-748
Author(s):  
Sultan Pathan ◽  
Anil Repale ◽  
Girdhar Pal
Keyword(s):  
Aldol Condensation ◽  
Active Pharmaceutical Ingredients ◽  
Reaction Sequence ◽  
One Pot ◽  
Pharmaceutical Ingredients ◽  
One Pot Synthesis ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Work Up

Celecoxib containing pyrazole derivatives were synthesized by path aldol condensation of substituted ketone with trifluoroethyl acetate subsequently by cyclization of the formed chalcones with 4-methanesulfonylphenylhydrazine. Here, a one-pot synthesis of celecoxib and substituted analogues have been reported which are nonsteroidal anti-inflammatory drugs for their cyclooxygenase (COX) inhibition, anti-inflammatory activity and ulcerogenic liability. In order to intermediate work-up, a continuous one-pot synthesis has been developed, performing the entire reaction sequence that results in a shorter time with good yield.

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