scholarly journals Inside Cover: Activity Enhancement of G-Quadruplex/Hemin DNAzyme by Flanking d(CCC) (Chem. Eur. J. 12/2016)

2016 ◽  
Vol 22 (12) ◽  
pp. 3894-3894
Author(s):  
Tianjun Chang ◽  
Hongmei Gong ◽  
Pi Ding ◽  
Xiangjun Liu ◽  
Weiguo Li ◽  
...  
Keyword(s):  
G Quadruplex ◽  
Activity Enhancement

Activity Enhancement of G-Quadruplex/Hemin DNAzyme by Flanking d(CCC)

2016 ◽  
Vol 22 (12) ◽  
pp. 4015-4021 ◽  
Author(s):  
Tianjun Chang ◽  
Hongmei Gong ◽  
Pi Ding ◽  
Xiangjun Liu ◽  
Weiguo Li ◽  
...  
Keyword(s):  
G Quadruplex ◽  
Activity Enhancement

scholarly journals Dimeric and Multimeric DNA Aptamers for Highly Effective Protein Recognition

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5227 ◽  
Author(s):  
Claudia Riccardi ◽  
Ettore Napolitano ◽  
Domenica Musumeci ◽  
Daniela Montesarchio
Keyword(s):  
Binding Affinity ◽  
Anticancer Agents ◽  
Building Blocks ◽  
Protein Recognition ◽  
Therapeutic Activity ◽  
G Quadruplex ◽  
Biological Target ◽  
Activity Enhancement ◽  
Improved Performance ◽  
Target Binding

Multivalent interactions frequently occur in biological systems and typically provide higher binding affinity and selectivity in target recognition than when only monovalent interactions are operative. Thus, taking inspiration by nature, bivalent or multivalent nucleic acid aptamers recognizing a specific biological target have been extensively studied in the last decades. Indeed, oligonucleotide-based aptamers are suitable building blocks for the development of highly efficient multivalent systems since they can be easily modified and assembled exploiting proper connecting linkers of different nature. Thus, substantial research efforts have been put in the construction of dimeric/multimeric versions of effective aptamers with various degrees of success in target binding affinity or therapeutic activity enhancement. The present review summarizes recent advances in the design and development of dimeric and multimeric DNA-based aptamers, including those forming G-quadruplex (G4) structures, recognizing different key proteins in relevant pathological processes. Most of the designed constructs have shown improved performance in terms of binding affinity or therapeutic activity as anti-inflammatory, antiviral, anticoagulant, and anticancer agents and their number is certainly bound to grow in the next future.

Activity enhancement of G-quadruplex/hemin DNAzyme by spermine

RSC Advances ◽  
2014 ◽  
Vol 4 (3) ◽  
pp. 1441-1448 ◽  
Author(s):  
Cui Qi ◽  
Nan Zhang ◽  
Jingli Yan ◽  
Xiangjun Liu ◽  
Tao Bing ◽  
...  
Keyword(s):  
G Quadruplex ◽  
Activity Enhancement
Sign in / Sign up

Export Citation Format

Share Document