Lewis Acid Catalyzed Asymmetric Three-Component Coupling Reaction: Facile Synthesis of α-Fluoromethylated Tertiary Alcohols

2015 ◽  
Vol 21 (49) ◽  
pp. 17565-17569 ◽  
Author(s):  
Kohsuke Aikawa ◽  
Daisuke Kondo ◽  
Kazuya Honda ◽  
Koichi Mikami
Keyword(s):  
Lewis Acid ◽  
Coupling Reaction ◽  
Facile Synthesis ◽  
Tertiary Alcohols ◽  
Acid Catalyzed ◽  
Three Component Coupling

Gold/Lewis acid catalyzed oxidative cyclization involving activation of nitriles

2020 ◽  
Vol 56 (99) ◽  
pp. 15581-15584
Author(s):  
Ali Wang ◽  
Xin Xie ◽  
Chunli Zhang ◽  
Yuanhong Liu
Keyword(s):  
Lewis Acid ◽  
Oxidative Cyclization ◽  
Facile Synthesis ◽  
Acid Catalyzed

A dual gold/Lewis acid-catalyzed oxidative cyclization of alkyne–nitriles with water or alcohol allows a facile synthesis of functionalized isoquinolin-1(2H)-ones and 1-alkoxy-isoquinolines.

A bromine-radical mediated three-component reaction comprising allenes, electron-deficient alkenes and allyl bromides: facile synthesis of 2-bromo-1,7-dienes

2014 ◽  
Vol 50 (45) ◽  
pp. 5993-5996 ◽  
Author(s):  
Takashi Kippo ◽  
Ilhyong Ryu
Keyword(s):  
Coupling Reaction ◽  
Facile Synthesis ◽  
Three Component Reaction ◽  
High Yields ◽  
Three Component Coupling

A bromine-radical mediated three-component coupling reaction was effectively achieved by the use of allenes, electron-deficient alkenes, and allyl bromides and led to the synthesis of 2-bromo-1,7-dienes in good to high yields.

Facile Synthesis of (-)-Ascochlorin Using Palladium-Catalyzed Three Component Coupling Reaction.

ChemInform ◽  
2007 ◽  
Vol 38 (41) ◽  
Author(s):  
Makoto Aoki ◽  
Kenji Kawashima ◽  
Hirohisa Fujihara ◽  
Isao Shimizu
Keyword(s):  
Coupling Reaction ◽  
Facile Synthesis ◽  
Palladium Catalyzed ◽  
Three Component Coupling

scholarly journals Synergistic Brønsted/Lewis Acid Catalyzed Aromatic Alkylation with Unactivated Tertiary Alcohols or Di-tert-Butylperoxide to Synthesize Quaternary Carbon Centers

2021 ◽  
Author(s):  
Aaron Pan ◽  
Maja Chojnacka ◽  
Robert Crowley ◽  
Lucas Gottemann ◽  
Brandon Haines ◽  
...  
Keyword(s):  
Dft Calculations ◽  
Lewis Acid ◽  
Acid Catalysis ◽  
Alkylating Agents ◽  
Environmentally Benign ◽  
Quaternary Carbon ◽  
Tertiary Alcohols ◽  
Carbon Centers ◽  
Acid Catalyzed ◽  
Site Selective

Dual Brønsted/Lewis acid catalysis involving environmentally benign, readily accessible protic acid and iron promotes site-selective tert-butylation of electron-rich arenes using di-tert-butylperoxide. This transformation inspired the development of a synergistic Brønsted/Lewis acid catalyzed aromatic alkylation that fills a gap in the Friedel–Crafts reaction literature by employing unactivated tertiary alcohols as alkylating agents, leading to new quaternary carbon centers. Corroborated by DFT calculations, the Lewis acid serves a role in enhancing the acidity of the Brønsted acid. The use of non-allylic, non-benzylic, and non-propargylic tertiary alcohols represents an underexplored area in Friedel–Crafts reactivity.

Lewis Acid Catalyzed Regiospecific Cross-Dehydrative Coupling Reaction of 2-Furylcarbinols with β-Keto Amides or 4-Hydroxycoumarins: A Route to Furyl Enols

2016 ◽  
Vol 81 (12) ◽  
pp. 5228-5235 ◽  
Author(s):  
Maozhong Miao ◽  
Yi Luo ◽  
Hongli Li ◽  
Xin Xu ◽  
Zhengkai Chen ◽  
...  
Keyword(s):  
Lewis Acid ◽  
Coupling Reaction ◽  
Acid Catalyzed

Copper(i)/Lewis acid triggered ring-opening coupling reaction of cyclopropenes with nitriles

RSC Advances ◽  
2015 ◽  
Vol 5 (33) ◽  
pp. 26335-26338 ◽  
Author(s):  
Huawen Huang ◽  
Xiaochen Ji ◽  
Fuhong Xiao ◽  
Guo-Jun Deng
Keyword(s):  
Lewis Acid ◽  
Ring Opening ◽  
Coupling Reaction ◽  
Facile Synthesis

A ring-opening coupling reaction of D–A cyclopropenes and nitriles is described for the facile synthesis of γ-amino ketones.

Facile Synthesis of Oxime Amino Ethers via Lewis Acid Catalyzed SN2-Type Ring Opening of Activated Aziridines with Aryl Aldehyde Oximes

Synlett ◽  
2020 ◽  
Vol 31 (07) ◽  
pp. 708-712
Author(s):  
Aditya Bhattacharyya ◽  
Subhomoy Das ◽  
Navya Chauhan ◽  
Pronay K. Biswas ◽  
Manas K. Ghorai
Keyword(s):  
Lewis Acid ◽  
Ring Opening ◽  
Facile Synthesis ◽  
Simple Strategy ◽  
Wide Range ◽  
Aryl Aldehyde ◽  
Acid Catalyzed ◽  
High Yields

A simple strategy to access a wide range of substituted oxime amino ethers in good to high yields via Lewis acid catalyzed SN2-type ring opening of activated aziridines with aryl aldehyde oximes is reported.

Sign in / Sign up

Export Citation Format

Share Document