Tridentate Lewis Acids Based on 1,3,5-Trisilacyclohexane Backbones and an Example of Their Host-Guest Chemistry

2015 ◽  
Vol 21 (35) ◽  
pp. 12436-12448 ◽  
Author(s):  
Eugen Weisheim ◽  
Christian G. Reuter ◽  
Peter Heinrichs ◽  
Yury V. Vishnevskiy ◽  
Andreas Mix ◽  
...  
Keyword(s):  
Lewis Acids ◽  
Guest Chemistry

Synthesis of a bifunctional boron-Lewis acid and studies on host-guest chemistry using pyridine and TMPD

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Jens Rudlof ◽  
Beate Neumann ◽  
Hans-Georg Stammler ◽  
Norbert W. Mitzel
Keyword(s):  
Solid State ◽  
Lewis Acid ◽  
Lewis Acids ◽  
Structure Elucidation ◽  
Decomposition Product ◽  
Functional Distance ◽  
Solid State Structures ◽  
Guest Chemistry

Abstract Based on the previously described bifunctional Lewis acid with a functional distance of the boron functions of 4.918(2) Å, the development of a further bifunctional, boron-containing Lewis acid with a wider functional distance is demonstrated. Again, a stannylated precursor was used and the Lewis-acidic boron functions were introduced by means of tin-boron exchange. The general suitability of this class of compounds for the formation of host-guest-complexes is demonstrated by NMR experiments and by solid-state structures using pyridine and TMPD (N 1,N 1,N 4,N 4-tetramethylbenzene-1,4-diamine) as Lewis basic guests. The influence of traces of moisture on the boron-containing, bifunctional Lewis acids was investigated by the structure elucidation of a decomposition product.

Tridentate Lewis-acids based on triphenylsilane

2017 ◽  
Vol 46 (5) ◽  
pp. 1645-1659 ◽  
Author(s):  
Janek Tomaschautzky ◽  
Beate Neumann ◽  
Hans-Georg Stammler ◽  
Andreas Mix ◽  
Norbert W. Mitzel
Keyword(s):  
Solid State ◽  
Lewis Acids ◽  
Building Blocks ◽  
State Structure ◽  
Solid State Structure ◽  
Guest Chemistry

Triphenylsilanes are versatile propeller-shaped building blocks and have been used for the syntheses of several novel poly-Lewis-acids. The first solid-state structure of a bisma-silatriptycene as well as investigations in host–guest chemistry of a triple alane with a threefold amine are reported.

Titration Simulations for Understanding of the Binding Equilibrium

2020 ◽  
Author(s):  
Dae Hyup Sohn
Keyword(s):  
Equilibrium Model ◽  
Binding Sites ◽  
Binding Constants ◽  
Reliability Evaluation ◽  
Binding Isotherm ◽  
Guest Chemistry

<p>The reliability evaluation of the predicted binding constants in numerous models is also a challenge for supramolecular host-guest chemistry. Here, I briefly formulate binding isotherm with the derivation of the multivalent equilibrium model for the chemist who wants to determine the binding constants of their compounds. This article gives an in-depth understanding of the stoichiometry of binding equilibrium to take divalent binding equilibria bearing two structurally identical binding sites as an example. The stoichiometry of binding equilibrium is affected by (1) the cooperativity of complex, (2) the concentration of titration media, and (3) the equivalents of guests. The simulations were conducted with simple Python codes.</p>

Enantioselective Recognition of Chiral Guests by the Water-Soluble Chiral Keplerate {Mo132} Spherical Capsule with 30 Inner Lactate Ligands

2019 ◽  
Author(s):  
Nancy Watfa ◽  
Weimin Xuan ◽  
Zoe Sinclair ◽  
Robert Pow ◽  
Yousef Abul-Haija ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Chiral Recognition ◽  
Association Constants ◽  
Water Soluble ◽  
Enantioselective Recognition ◽  
H Nmr ◽  
Dosy Nmr ◽  
Spherical Capsule ◽  
Surface Pores ◽  
Guest Chemistry

Investigations of chiral host guest chemistry are important to explore recognition in confined environments. Here, by synthesizing water-soluble chiral porous nanocapsule based on the inorganic metal-oxo Keplerate-type cluster, {Mo<sub>132</sub>} with chiral lactate ligands with the composition [Mo<sub>132</sub>O<sub>372</sub>(H<sub>2</sub>O)<sub>72</sub>(<i>x-</i>Lactate)<sub>30</sub>]<sup>42-</sup> (<i>x</i> = D or L), it was possible to study the interaction with a chiral guest, L/D-carnitine and (<i>R</i>/<i>S</i>)-2-butanol in aqueous solution. The enantioselective recognition was studied by quantitative <sup>1</sup>H NMR and <sup>1</sup>H DOSY NMR which highlighted that the chiral recognition is regulated by two distinct sites. Differences in the association constants (K) of L- and D-carnitine, which, due to their charge, are generally restricted from entering the interior of the host, are observed, indicating that their recognition predominantly occurs at the surface pores of the structure. Conversely, a larger difference in association constants (K<i><sub>S</sub></i>/K<i><sub>R</sub></i> = 3) is observed for recognition within the capsule interior of (<i>R</i>)- and (<i>S</i>)-2-butanol.

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