Carbon Dots (C-dots) from Cow Manure with Impressive Subcellular Selectivity Tuned by Simple Chemical Modification

2015 ◽  
Vol 21 (13) ◽  
pp. 5055-5060 ◽  
Author(s):  
Cintya D'Angelis do E. S. Barbosa ◽  
José R. Corrêa ◽  
Gisele A. Medeiros ◽  
Gabrielle Barreto ◽  
Kelly G. Magalhães ◽  
...  
Keyword(s):  
Chemical Modification ◽  
Carbon Dots ◽  
Cow Manure ◽  
Simple Chemical

Simple Chemical Modification Using Perfluoroalkyl‐Substituted Stable Nitrile N ‐Oxide on Bulk Surface via Catalyst‐Free Click Reaction

2020 ◽  
Vol 5 (17) ◽  
pp. 5312-5315 ◽  
Author(s):  
Chen‐Gang Wang ◽  
Sumitra Cheawchan ◽  
Airong Qiagedeer ◽  
Shunsuke Monjiyama ◽  
Satoshi Uchida ◽  
...  
Keyword(s):  
Chemical Modification ◽  
Click Reaction ◽  
Catalyst Free ◽  
Bulk Surface ◽  
Simple Chemical

scholarly journals Facile synthesis of preformed mixed nano-carbon structure from low rank coal

2018 ◽  
Vol 36 (1) ◽  
pp. 14-20 ◽  
Author(s):  
B. Manoj ◽  
Ashlin M. Raj ◽  
George Thomas Chirayil
Keyword(s):  
Quantum Dots ◽  
Carbon Dots ◽  
Bituminous Coal ◽  
Graphene Quantum Dots ◽  
Energy Resource ◽  
Low Rank ◽  
Tem Analysis ◽  
Graphene Layers ◽  
Simple Chemical ◽  
Nano Carbon

Abstract Coal is a natural energy resource which is mainly used for energy production via combustion. Coal has nanocrystals embedded in it, formed during the coalification process, and is an ideal precursor for nano-carbon dots and diamonds. Herein, we report a facile top-down method to synthesise nanodots and diamonds of the size of 5 nm to 10 nm from three different types of coal by simple chemical leaching. TEM analysis revealed the formation of a mixture of carbon dots, graphene layers, and quantum dots in bituminous coal and sub-bituminous coal. Raman analysis confirmed the existence of synthesized nanodiamond and nano-carbon mixed phase with defects associated with it. It is concluded that graphene quantum dots, nanodiamonds, graphene sheets and carbon dots present in coal can be extracted by simple chemical treatment. These structures can be tuned to photoluminescent material for various optoelectronic applications or energy harvesting devices like super capacitors.

scholarly journals From cow manure to bioactive carbon dots: a light-up probe for bioimaging investigations, glucose detection and potential immunotherapy agent for melanoma skin cancer

RSC Advances ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 6346-6352
Author(s):  
Frederico Hillesheim Horst ◽  
Carime Vitória da Silva Rodrigues ◽  
Pedro Henrique Pimenta Rocha Carvalho ◽  
Amanda Monteiro Leite ◽  
Ricardo Bentes Azevedo ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Carbon Dots ◽  
Glucose Detection ◽  
Cow Manure ◽  
Immunological Effect ◽  
Effect Of Light ◽  
Melanoma Skin

Investigation of the immunological effect of light-up carbon-dots on cancer-bearing mice.

The Development of New Low-Molecular-Weight Factor Xa Inhibitors That Are Potential Anticoagulants

2021 ◽  
Vol 18 ◽  
Author(s):  
Dmitry G. Tovbin ◽  
Dmitry N. Tarasov ◽  
Dmitry V. Malakhov ◽  
Natalia A. Tserkovnikova ◽  
Arseniy V. Aybush ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Chemical Synthesis ◽  
Chemical Modification ◽  
Oral Anticoagulants ◽  
Factor Xa ◽  
Activity Measurement ◽  
Low Molecular Weight ◽  
Structure Based Drug Design ◽  
Nanomolar Concentration ◽  
Simple Chemical

Background: Despite the introduction of direct oral anticoagulants, the search for new oral anticoagulants remains an urgent task. Objective: Using the docking and scoring, based on physical methods, simple chemical rules, methods of synthesis and activity measurement, to develop new low-molecular-weight inhibitors of factor Xa, which are potential anticoagulants. Method: The development of leads was based on chemical synthesis and the structure-based drug design methods. The basic idea is to combine the two approaches: one based on predictive modeling, and the other – on the experimental data. Results: In frame of our concept we developed some nanomolar leads. Further chemical modification improved the inhibition constant by more than one order. Discussion: The method proposed in this paper, as well as other methods, includes virtual screening, screening, chemical synthesis and activity measurement. However, the most time – consuming process in this method (chemical synthesis) was decided to simplify and reduce the cost to the extent that it could be allowed: a very simple chemical reaction was chosen - the formation of an amide bond. Conclusion: In this work, we demonstrated how, using simple chemical rules, based on the structure-based drug design, substances with a nanomolar concentration of activity can be developed. Using our method, we developed substances with nanomolar concentration of activity. Further chemical modification of this leads improved the inhibition constant by more than one order.

scholarly journals Targeting an Artificial Metal Nuclease to DNA by a Simple Chemical Modification and Its Drastic Effect on Catalysis

2019 ◽  
Vol 11 (3) ◽  
pp. 286-291
Author(s):  
Nathalia Castilho ◽  
Philipe Gabriel ◽  
Tiago Pacheco Camargo ◽  
Ademir Neves ◽  
Hernán Terenzi
Keyword(s):  
Chemical Modification ◽  
Simple Chemical ◽  
Drastic Effect

scholarly journals Effect of Disposition of Mannich Antimalarial Agents on Their Pharmacology and Toxicology

1998 ◽  
Vol 42 (9) ◽  
pp. 2410-2416 ◽  
Author(s):  
J. E. Ruscoe ◽  
M. D. Tingle ◽  
P. M. O’Neill ◽  
S. A. Ward ◽  
B. K. Park
Keyword(s):  
Chemical Modification ◽  
Antimalarial Activity ◽  
Repeated Administration ◽  
Metabolic Clearance ◽  
Chemical Modifications ◽  
Drug Induced ◽  
Antimalarial Agents ◽  
Simple Chemical ◽  
Pharmacology And Toxicology

ABSTRACT The use of the antimalarial agent amodiaquine has been curtailed due to drug-induced idiosyncratic reactions. These have been attributed to the formation of a protein-reactive quinoneimine species via oxidation of the 4-aminophenol group. Therefore, the effects of chemical modifications on the disposition of amodiaquine in relation to its metabolism, distribution, and pharmacological activity have been investigated. The inclusion of a group at the C-5′ position of amodiaquine reduced or eliminated bioactivation, as determined by glutathione conjugate formation in vivo. This can be seen in two series of C-5′-substituted compounds: the bis-Mannich antimalarial agents, including cycloquine and pyronaridine, and mono-Mannich antimalarial agents containing a 5′-chlorophenyl group (tebuquine and 5′-ClPAQ). Chemical substitution at the C-5′ position also resulted in compounds which underwent slower elimination (<5% of the dose excreted into bile and urine, compared with 50% for amodiaquine) and increased levels of accumulation in tissue (10% of the dose in the liver at 48 h compared with 1% with amodiaquine). This may be due to an increase in either the lipophilicity or the basicity of the analogs and may reflect the lack of metabolic clearance for these compounds. The alteration in the disposition following the introduction of the C-5′ substituent resulted in an increased duration of antimalarial activity in the mouse compared with that for amodiaquine. While this is desirable in the treatment of malaria, repeated administration for prophylaxis may induce toxicity through accumulation. Therefore, by simple chemical modification it is possible to block the bioactivation of amodiaquine while maintaining and in some cases extending the duration of antimalarial activity.

scholarly journals New Coumarin Dipicolinate Europium Complexes with a Rich Chemical Speciation and Tunable Luminescence

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1265
Author(s):  
Sebastiano Di Di Pietro ◽  
Dalila Iacopini ◽  
Aldo Moscardini ◽  
Ranieri Bizzarri ◽  
Mauro Pineschi ◽  
...  
Keyword(s):  
Chemical Modification ◽  
Emission Spectroscopy ◽  
Lanthanide Complexes ◽  
Chemical Speciation ◽  
Photophysical Properties ◽  
Molecular Probes ◽  
Paramagnetic Nmr ◽  
Europium Complexes ◽  
Wide Range ◽  
Simple Chemical

Europium (III) luminescent chelates possess intrinsic photophysical properties that are extremely useful in a wide range of applications. The lack of examples of coumarin-based lanthanide complexes is mainly due to poor photo-sensitization attempts. However, with the appeal of using such a versatile scaffold as antenna, especially in the development of responsive molecular probes, it is worth the effort to research new structural motifs. In this work, we present a series of two new tris coumarin-dipicolinate europium (III) complexes, specifically tailored to be either a mono or a dual emitter, tuning their properties with a simple chemical modification. We also encountered a rich chemical speciation in solution, studied in detail by means of paramagnetic NMR and emission spectroscopy.

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