Comparison Between Polypyridyl and Cyclometalated Ruthenium(II) Complexes: Anticancer Activities Against 2D and 3D Cancer Models

2014 ◽  
Vol 21 (2) ◽  
pp. 715-725 ◽  
Author(s):  
Huaiyi Huang ◽  
Pingyu Zhang ◽  
Hongmin Chen ◽  
Liangnian Ji ◽  
Hui Chao
Keyword(s):  
Anticancer Activities ◽  
Cancer Models ◽  
2D And 3D

Gold(i) and gold(iii) phosphine complexes: synthesis, anticancer activities towards 2D and 3D cancer models, and apoptosis inducing properties

2018 ◽  
Vol 47 (43) ◽  
pp. 15312-15323 ◽  
Author(s):  
T. Srinivasa Reddy ◽  
Steven H. Privér ◽  
Vijay V. Rao ◽  
Nedaossadat Mirzadeh ◽  
Suresh K. Bhargava
Keyword(s):  
Anticancer Activity ◽  
Anticancer Activities ◽  
Phosphine Complexes ◽  
Cancer Models ◽  
2D And 3D

Herein we report the synthesis of gold(i) and gold(iii) complexes of tris(4-methoxyphenyl)phosphine and tris(2,6-dimethoxyphenyl)phosphine and their anticancer activity towards 2D and 3D cancer models.

scholarly journals Fucoxanthin Holds Potential to Become a Drug Adjuvant in Breast Cancer Treatment: Evidence from 2D and 3D Cell Cultures

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4288
Author(s):  
Fernanda Malhão ◽  
Ana Catarina Macedo ◽  
Carla Costa ◽  
Eduardo Rocha ◽  
Alice Abreu Ramos
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
3D Models ◽  
Anticancer Activities ◽  
Cytotoxic Effects ◽  
3D Cultures ◽  
3D Cell Cultures ◽  
Tumoral Cell ◽  
Microscopy Techniques ◽  
2D And 3D

Fucoxanthin (Fx) is a carotenoid derived from marine organisms that exhibits anticancer activities. However, its role as a potential drug adjuvant in breast cancer (BC) treatment is still poorly explored. Firstly, this study investigated the cytotoxic effects of Fx alone and combined with doxorubicin (Dox) and cisplatin (Cis) on a panel of 2D-cultured BC cell lines (MCF7, SKBR3 and MDA-MB-231) and one non-tumoral cell line (MCF12A). Fucoxanthin induced cytotoxicity against all the cell lines and potentiated Dox cytotoxic effects towards the SKBR3 and MDA-MB-231 cells. The combination triggering the highest cytotoxicity (Fx 10 µM + Dox 1 µM in MDA-MB-231) additionally showed significant induction of cell death and genotoxic effects, relative to control. In sequence, the same combination was tested on 3D cultures using a multi-endpoint approach involving bioactivity assays and microscopy techniques. Similar to 2D cultures, the combination of Fx and Dox showed higher cytotoxic effects on 3D cultures compared to the isolated compounds. Furthermore, this combination increased the number of apoptotic cells, decreased cell proliferation, and caused structural and ultrastructural damages on the 3D models. Overall, our findings suggest Fx has potential to become an adjuvant for Dox chemotherapy regimens in BC treatment.

scholarly journals Understanding the Impact of 2D and 3D Fibroblast Cultures on In Vitro Breast Cancer Models

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e76373 ◽  
Author(s):  
Kyung Eun Sung ◽  
Xiaojing Su ◽  
Erwin Berthier ◽  
Carolyn Pehlke ◽  
Andreas Friedl ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fibroblast Cultures ◽  
Cancer Models ◽  
2D And 3D ◽  
The Impact

scholarly journals Efficacy of photochemical internalisation using disulfonated chlorin and porphyrin photosensitisers: An in vitro study in 2D and 3D prostate cancer models

2017 ◽  
Vol 393 ◽  
pp. 68-75 ◽  
Author(s):  
Alejandra Martinez de Pinillos Bayona ◽  
Josephine H. Woodhams ◽  
Hayley Pye ◽  
Rifat A. Hamoudi ◽  
Caroline M. Moore ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
In Vitro Study ◽  
Vitro Study ◽  
Cancer Models ◽  
2D And 3D

Influence of nanoparticle shapes on cellular uptake of paclitaxel loaded nanoparticles in 2D and 3D cancer models

2017 ◽  
Vol 8 (21) ◽  
pp. 3317-3326 ◽  
Author(s):  
Jiacheng Zhao ◽  
Hongxu Lu ◽  
Sandy Wong ◽  
Mingxia Lu ◽  
Pu Xiao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Cellular Uptake ◽  
Cancer Models ◽  
Anti Cancer ◽  
2D And 3D ◽  
Nanoparticle Shapes

Enhanced cellular uptake and efficient penetration of nanocarriers inside tumors is paramount to successful anti-cancer therapy.

Effect of nanoemulsion modification with chitosan and sodium alginate on the topical delivery and efficacy of the cytotoxic agent piplartine in 2D and 3D skin cancer models

2020 ◽  
Vol 165 ◽  
pp. 1055-1065 ◽  
Author(s):  
Daniela V. Giacone ◽  
Vanessa F.M.C. Dartora ◽  
Jenyffer K.R. de Matos ◽  
Julia S. Passos ◽  
Daniel A.G. Miranda ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Sodium Alginate ◽  
Topical Delivery ◽  
Cytotoxic Agent ◽  
Cancer Models ◽  
2D And 3D ◽  
3D Skin
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