scholarly journals Corrigendum: Exocyclic Control of Turn Induction in Macrocyclic Peptide Scaffolds

2014 ◽  
Vol 20 (11) ◽  
pp. 2983-2983
Author(s):  
Serge Zaretsky ◽  
Conor C. G. Scully ◽  
Alan J. Lough ◽  
Andrei K. Yudin
Keyword(s):  
Peptide Scaffolds ◽  
Macrocyclic Peptide

An Integrated Imaging Probe Design: The Synthesis of99mTc/Re-Containing Macrocyclic Peptide Scaffolds

2014 ◽  
Vol 21 (2) ◽  
pp. 568-578 ◽  
Author(s):  
Jennifer L. Hickey ◽  
Emily J. Simpson ◽  
Jinqiang Hou ◽  
Leonard G. Luyt
Keyword(s):  
Probe Design ◽  
Imaging Probe ◽  
Peptide Scaffolds ◽  
Macrocyclic Peptide

The effect of backbone flexibility on site-selective modification of macrocycles

2016 ◽  
Vol 14 (43) ◽  
pp. 10230-10237 ◽  
Author(s):  
Conor C. G. Scully ◽  
Christopher J. White ◽  
Andrei K. Yudin
Keyword(s):  
Ring Opening ◽  
Backbone Flexibility ◽  
Peptide Scaffolds ◽  
Site Selective ◽  
Macrocyclic Peptide

The interplay of rotatable backbone torsions determines the ring-opening regioselectivity of electrophilic aziridines in macrocyclic peptide scaffolds.

Frontispiece: An Integrated Imaging Probe Design: The Synthesis of99mTc/Re-Containing Macrocyclic Peptide Scaffolds

2015 ◽  
Vol 21 (2) ◽  
pp. n/a-n/a
Author(s):  
Jennifer L. Hickey ◽  
Emily J. Simpson ◽  
Jinqiang Hou ◽  
Leonard G. Luyt
Keyword(s):  
Probe Design ◽  
Imaging Probe ◽  
Peptide Scaffolds ◽  
Macrocyclic Peptide

Exocyclic Control of Turn Induction in Macrocyclic Peptide Scaffolds

2013 ◽  
Vol 19 (52) ◽  
pp. 17668-17672 ◽  
Author(s):  
Serge Zaretsky ◽  
Conor C. G. Scully ◽  
Alan J. Lough ◽  
Andrei K. Yudin
Keyword(s):  
Peptide Scaffolds ◽  
Macrocyclic Peptide

scholarly journals Conformational interplay in hybrid peptide-helical aromatic foldamer macrocycles

2021 ◽  
Author(s):  
Sebastian Dengler ◽  
Pradeep Kumar Mandal ◽  
Lars Allmendinger ◽  
Céline Douat ◽  
Ivan Huc
Keyword(s):  
Important Class ◽  
Hybrid Peptide ◽  
Bioactive Substances ◽  
Macrocyclic Peptides ◽  
Macrocyclic Peptide

Macrocyclic peptides are an important class of bioactive substances. When inserting an aromatic foldamer segment in a macrocyclic peptide, the strong folding propensity of the former may influence the conformation...

Design of Thioether Cyclic Peptide Scaffolds with Passive Permeability and Oral Exposure

2021 ◽  
Vol 64 (5) ◽  
pp. 2622-2633
Author(s):  
Andrei A. Golosov ◽  
Alec N. Flyer ◽  
Jakal Amin ◽  
Charles Babu ◽  
Christian Gampe ◽  
...  
Keyword(s):  
Cyclic Peptide ◽  
Oral Exposure ◽  
Passive Permeability ◽  
Peptide Scaffolds

scholarly journals Surface Characterization and Physiochemical Evaluation of P(3HB-co-4HB)-Collagen Peptide Scaffolds with Silver Sulfadiazine as Antimicrobial Agent for Potential Infection-Resistance Biomaterial

Polymers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 2454
Author(s):  
Sevakumaran Vigneswari ◽  
Tana Poorani Gurusamy ◽  
Wan M. Khairul ◽  
Abdul Khalil H.P.S. ◽  
Seeram Ramakrishna ◽  
...  
Keyword(s):  
Controlled Release ◽  
Antimicrobial Agent ◽  
Surface Characterization ◽  
Biomedical Application ◽  
Physical And Mechanical Properties ◽  
Silver Sulfadiazine ◽  
Salt Leaching ◽  
Collagen Peptides ◽  
Collagen Peptide ◽  
Peptide Scaffolds

Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) [P(3HB-co-4HB)] is a bacterial derived biopolymer widely known for its unique physical and mechanical properties to be used in biomedical application. In this study, antimicrobial agent silver sulfadiazine (SSD) coat/collagen peptide coat-P(3HB-co-4HB) (SCCC) and SSD blend/collagen peptide coat-P(3HB-co-4HB) scaffolds (SBCC) were fabricated using a green salt leaching technique combined with freeze-drying. This was then followed by the incorporation of collagen peptides at various concentrations (2.5–12.5 wt.%) to P(3HB-co-4HB) using collagen-coating. As a result, two types of P(3HB-co-4HB) scaffolds were fabricated, including SCCC and SBCC scaffolds. The increasing concentrations of collagen peptides from 2.5 wt.% to 12.5 wt.% exhibited a decline in their porosity. The wettability and hydrophilicity increased as the concentration of collagen peptides in the scaffolds increased. In terms of the cytotoxic results, MTS assay demonstrated the L929 fibroblast scaffolds adhered well to the fabricated scaffolds. The 10 wt.% collagen peptides coated SCCC and SBCC scaffolds displayed highest cell proliferation rate. The antimicrobial analysis of the fabricated scaffolds exhibited 100% inhibition towards various pathogenic microorganisms. However, the SCCC scaffold exhibited 100% inhibition between 12 and 24 h, but the SBCC scaffolds with SSD impregnated in the scaffold had controlled release of the antimicrobial agent. Thus, this study will elucidate the surface interface-cell interactions of the SSD-P(3HB-co-4HB)-collagen peptide scaffolds and controlled release of SSD, antimicrobial agent.

scholarly journals A Macrocyclic Peptide that Serves as a Cocrystallization Ligand and Inhibits the Function of a MATE Family Transporter

Molecules ◽  
2013 ◽  
Vol 18 (9) ◽  
pp. 10514-10530 ◽  
Author(s):  
Christopher Hipolito ◽  
Yoshiki Tanaka ◽  
Takayuki Katoh ◽  
Osamu Nureki ◽  
Hiroaki Suga
Keyword(s):  
Macrocyclic Peptide
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