Escherichia coliβ-Galactosidase Inhibitors through Modifications at the Aglyconic Moiety: Experimental Evidence of Conformational Distortion in the Molecular Recognition Process

2013 ◽  
Vol 19 (13) ◽  
pp. 4262-4270 ◽  
Author(s):  
Luis Calle ◽  
Virginia Roldós ◽  
F. Javier Cañada ◽  
María Laura Uhrig ◽  
Alejandro J. Cagnoni ◽  
...  
1999 ◽  
Vol 55 (2) ◽  
pp. 209-215 ◽  
Author(s):  
Javier Ellena ◽  
Andrés E. Goeta ◽  
Judith A. K. Howard ◽  
Chick C. Wilson ◽  
Juan C. Autino ◽  
...  

An appreciable degree of pyramidalization of the amine N atom is observed in the title compound. The existence of polar chains, induced by N—H...O synthons, is confirmed. C—H...O interactions, not noted in a previous X-ray study, were found to stabilize further the known head-to-tail assembling of the chains. The structure can be described as non-polar (101) layers, embodying chains interlinked by centrosymmetric dimers, connected by C(aryl)—H...π interactions. The latter are not present in m-nitroaniline, 2-methyl-4-nitroaniline and other related compounds with chains built from similar N—H...O synthons and assembled head-to-head. This finding implies that an obvious relationship between molecular recognition patterns and crystal structures should not be assumed.


Author(s):  
Izuo Aoki ◽  
Takaaki Harada ◽  
Toru Sakaki ◽  
Yohko Kawahara ◽  
Seiji Shinkai

2003 ◽  
Vol 43 (supplement) ◽  
pp. S49
Author(s):  
T. Matsufuji ◽  
Y. Jinbo ◽  
Y. Izumi ◽  
H. yoshino ◽  
T. Fujisawa

2015 ◽  
Vol 91 ◽  
pp. 100-108 ◽  
Author(s):  
Luigi Russo ◽  
Maddalena Palmieri ◽  
Jolanda Valentina Caso ◽  
Gianluca D' Abrosca ◽  
Donatella Diana ◽  
...  

1995 ◽  
Vol 28 (26) ◽  
pp. 8875-8876 ◽  
Author(s):  
Takashi Kato ◽  
Masahisa Nakano ◽  
Tomonori Moteki ◽  
Toshiyuki Uryu ◽  
Seiji Ujiie

Author(s):  
Oscar Castillo ◽  
Antonio Luque ◽  
Juan P. García-Terán ◽  
Pilar Amo-Ochoa

2002 ◽  
Vol 42 (supplement2) ◽  
pp. S183
Author(s):  
T. Matsufuji ◽  
Y. Jinbo ◽  
Y. Izumi ◽  
H. Yoshino ◽  
T. Fujisawa

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