Nanosheet-Enhanced Asymmetric Induction of Chiral α-Amino Acids in Catalytic Aldol Reaction

2012 ◽  
Vol 18 (48) ◽  
pp. 15323-15329 ◽  
Author(s):  
Li-Wei Zhao ◽  
Hui-Min Shi ◽  
Jiu-Zhao Wang ◽  
Jing He
Keyword(s):  
Amino Acids ◽  
Aldol Reaction ◽  
Asymmetric Induction

scholarly journals Enantioselective organocatalysis in the synthesis of biologically relevant compounds

2016 ◽  
Author(s):  
Lukasz Albrecht
Keyword(s):  
Organic Chemistry ◽  
Amino Acids ◽  
Organic Molecules ◽  
Asymmetric Induction ◽  
Chiral Catalyst ◽  
Biologically Relevant ◽  
Enantioselective Reactions ◽  
Asymmetric Organocatalysis ◽  
Biologically Relevant Molecules ◽  
Operational Simplicity

The development of methods for the preparation of biologically relevant compounds in an enantiomerically enriched form constitutes one of the most significant tasks in the contemporary organic chemistry. In particular, enantioselective reactions where prochiral substrates are converted into enantiomerically enriched products in the presence of chiral catalyst are of great importance. Recently, asymmetric organocatalysis, where simple organic molecules are used as catalysts of various enantiodifferentiating reactions, has become a highly useful synthetic tool enabling for the efficient asymmetric induction based on diverse activation modes. Herein, we report our studies on organocatalytic, enantioselective strategies for the synthesis of biologically relevant molecules such as: quaternary α-amino acids and their isoelectronic analogs α-aminophosphonates, benzo[1,5]oxazocines, α-methylidene-δ-lactones, α-alkylidene-ketones, furfural derivatives, and benzothiophenes. The devised approaches utilize readily available chiral organocatalysts to control stereo-chemical reaction outcomes. Operational simplicity, efficiency and high enantio- and diastereoselectivities are the main benefits of the developed strategies.

scholarly journals Recent Advances in Substrate-Controlled Asymmetric Induction Derived from Chiral Pool α-Amino Acids for Natural Product Synthesis

Molecules ◽  
2016 ◽  
Vol 21 (7) ◽  
pp. 951 ◽  
Author(s):  
Seung-Mann Paek ◽  
Myeonggyo Jeong ◽  
Jeyun Jo ◽  
Yu Heo ◽  
Young Han ◽  
...  
Keyword(s):  
Amino Acids ◽  
Natural Product ◽  
Natural Product Synthesis ◽  
Asymmetric Induction ◽  
Recent Advances

Selective Michael−Aldol Reaction by Use of Sterically Hindered Aluminum Aryloxides as Lewis Acids:  An Easy Approach to Cyclobutane Amino Acids

2005 ◽  
Vol 7 (16) ◽  
pp. 3597-3600 ◽  
Author(s):  
Alberto Avenoza ◽  
Jesús H. Busto ◽  
Noelia Canal ◽  
Jesús M. Peregrina ◽  
Marta Pérez-Fernández
Keyword(s):  
Amino Acids ◽  
Lewis Acids ◽  
Aldol Reaction ◽  
Sterically Hindered

Direct Synthesis of β-Hydroxy-α-amino Acids via Diastereoselective Decarboxylative Aldol Reaction

2013 ◽  
Vol 15 (22) ◽  
pp. 5770-5773 ◽  
Author(s):  
Yuttapong Singjunla ◽  
Jérôme Baudoux ◽  
Jacques Rouden
Keyword(s):  
Amino Acids ◽  
Direct Synthesis ◽  
Aldol Reaction

ChemInform Abstract: 1,3-Asymmetric Induction via 1,5-Hydrogen Atom Translocation Reactions. Highly Enantioselective Synthesis of β-Substituted β-Amino Acids.

ChemInform ◽  
2010 ◽  
Vol 28 (1) ◽  
pp. no-no
Author(s):  
F. BEAULIEU ◽  
J. ARORA ◽  
U. VEITH ◽  
N. J. TAYLOR ◽  
B. J. CHAPELL ◽  
...  
Keyword(s):  
Amino Acids ◽  
Hydrogen Atom ◽  
Enantioselective Synthesis ◽  
Asymmetric Induction
Sign in / Sign up

Export Citation Format

Share Document