Ruthenium-Catalyzed Oxidative Coupling/Cyclization of Isoquinolones with Alkynes through CH/NH Activation: Mechanism Study and Synthesis of Dibenzo[a,g]quinolizin-8-one Derivatives

2012 ◽  
Vol 18 (40) ◽  
pp. 12873-12879 ◽  
Author(s):  
Bin Li ◽  
Huiliang Feng ◽  
Nuancheng Wang ◽  
Jianfeng Ma ◽  
Haibin Song ◽  
...  
Keyword(s):  
Oxidative Coupling ◽  
Activation Mechanism ◽  
Mechanism Study

Activation Mechanism Study of Dandelion-Like Co9S8Nanotubes in Supercapacitors

2014 ◽  
Vol 161 (6) ◽  
pp. A996-A1000 ◽  
Author(s):  
Jingwen Yu ◽  
Houzhao Wan ◽  
Jianjun Jiang ◽  
Yunjun Ruan ◽  
Ling Miao ◽  
...  
Keyword(s):  
Activation Mechanism ◽  
Mechanism Study

Inhibition of NGLY1 inactivates the transcription factor Nrf1 and potentiates proteasome inhibitor cytotoxicity

2017 ◽  
Author(s):  
Carolyn Bertozzi ◽  
Fred Tomlin ◽  
Ulla Gerling-Driessen ◽  
Yi-Chang Liu ◽  
Ryan Flynn ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Small Molecule ◽  
Proteasome Inhibitor ◽  
Activation Mechanism ◽  
Cancer Drugs ◽  
Small Molecule Library ◽  
Library Screen ◽  
In Cells

We discovered that the proteostasis modulating transcription factor Nrf1 requires cytosolic de-N-glycosylation by the N-glycanase NGly1 as part of its activation mechanism. Through a covalent small molecule library screen, we discovered an inhibitor of NGly1 that blocks Nrf1 activation in cells and potentiates the activity of proteasome inhibitor cancer drugs. The requirement of NGly1 for Nrf1 activity likely underlies several pathologies associated with a rare hereditary deficiency in NGly1.

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