Covalent Modification of Reduced Graphene Oxide by Means of Diazonium Chemistry and Use as a Drug-Delivery System

2012 ◽  
Vol 18 (46) ◽  
pp. 14708-14716 ◽  
Author(s):  
Guangcheng Wei ◽  
Miaomiao Yan ◽  
Renhao Dong ◽  
Dong Wang ◽  
Xiangzhu Zhou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Drug Delivery System ◽  
Delivery System ◽  
Covalent Modification ◽  
Reduced Graphene

Functionalized R9–reduced graphene oxide as an efficient nano-carrier for hydrophobic drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (78) ◽  
pp. 74072-74084 ◽  
Author(s):  
Mohaddeseh Hashemi ◽  
Amir Yadegari ◽  
Ghasem Yazdanpanah ◽  
Sayena Jabbehdari ◽  
Meisam Omidi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Drug Delivery System ◽  
Delivery System ◽  
Hydrophobic Drug ◽  
Smart Transportation ◽  
Reduced Graphene

A novel, stable, functionalized, and targeted graphene-based drug delivery system for smart transportation of hydrophobic agents is introduced.

scholarly journals A porous reduced graphene oxide/chitosan-based nanocarrier as a delivery system of doxorubicin

RSC Advances ◽  
2019 ◽  
Vol 9 (53) ◽  
pp. 30729-30735 ◽  
Author(s):  
N. Hazhir ◽  
F. Chekin ◽  
J. B. Raoof ◽  
Sh. Fathi
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Delivery System ◽  
Reduced Graphene

Nowadays, the concept of drug transmission is an important topic in the field of drug delivery research.

Doxorubicin Loaded Nanoparticle Consisting of Chitosan and Mannose Modified Graphene Oxide for Intracellular Drug Delivery and Anti-tumor Activity

2020 ◽  
Vol 13 (5) ◽  
pp. 5155-5164
Author(s):  
Meena K. S. ◽  
Sonia K ◽  
Alamelu Bai S
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Vitro Release ◽  
Cancer Drug ◽  
Hemolysis Assay ◽  
Functionalized Graphene Oxide ◽  
Intracellular Drug Delivery ◽  
Modified Graphene Oxide

In order to develop the efficiency and the specificity of anticancer drug delivery, we have designed an innovative nanocarrier. The nanocarrier system comprises of a multifunctional graphene oxide nanoparticle-based drug delivery system (GO-CS-M-DOX) as a novel platform for intracellular drug delivery of doxorubicin (DOX). Firstly, graphene oxide (GO) was synthesized by hummer’s method whose surface was functionalized by chitosan (CS) in order to obtain a more precise drug delivery, the system was then decorated with mannose (M). Further conjugation of an anti-cancer drug doxorubicin to the nanocarrier system resulted in GO-CS-M-DOX drug delivery system. The resultant conjugate was characterized for its physio-chemical properties and its biocompatibility was evaluated via hemolysis assay. The drug entrapment efficiency is as high as 90% and in vitro release studies of DOX under pH 5.3 is significantly higher than that under pH 7.4. The anticancer activity of the synthesized drug delivery system was studied by 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay against MCF-7 cell line. These results stated that the pH dependent multifunctional doxorubicin- chitosan functionalized graphene oxide based nanocarrier system, could lead to a promising and potential platform for intracellular delivery and cytotoxicity activity for variety of anticancer drugs.   

scholarly journals Polyethylene Glycol Functionalized Graphene Oxide Nanoparticles Loaded with Nigella sativa Extract: A Smart Antibacterial Therapeutic Drug Delivery System

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3067
Author(s):  
Mustafa A. Jihad ◽  
Farah T. M. Noori ◽  
Majid S. Jabir ◽  
Salim Albukhaty ◽  
Faizah A. AlMalki ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Grain Size ◽  
Cell Wall ◽  
Graphene Oxide ◽  
Polyethylene Glycol ◽  
Nucleic Acid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Nigella Sativa ◽  
Seed Extract

Flaky graphene oxide (GO) nanoparticles (NPs) were synthesized using Hummer’s method and then capped with polyethylene glycol (PEG) by an esterification reaction, then loaded with Nigella sativa (N. sativa) seed extract. Aiming to investigate their potential use as a smart drug delivery system against Staphylococcus aureus and Escherichia coli, the spectral and structural characteristics of GO-PEG NPs were comprehensively analyzed by XRD, AFM, TEM, FTIR, and UV- Vis. XRD patterns revealed that GO-PEG had different crystalline structures and defects, as well as a higher interlayer spacing. AFM results showed GONPs with the main grain size of 24.41 nm, while GONPs–PEG revealed graphene oxide aggregation with the main grain size of 287.04 nm after loading N. sativa seed extract, which was verified by TEM examination. A strong OH bond appeared in FTIR spectra. Furthermore, UV- Vis absorbance peaks at (275, 284, 324, and 327) nm seemed to be correlated with GONPs, GO–PEG, N. sativa seed extract, and GO –PEG- N. sativa extract. The drug delivery system was observed to destroy the bacteria by permeating the bacterial nucleic acid and cytoplasmic membrane, resulting in the loss of cell wall integrity, nucleic acid damage, and increased cell-wall permeability.

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