Mechanistic Studies on the Reaction between Cob(II)alamin and Peroxynitrite: Evidence for a Dual Role for Cob(II)alamin as a Scavenger of Peroxynitrous Acid and Nitrogen Dioxide

2011 ◽  
Vol 17 (42) ◽  
pp. 11805-11812 ◽  
Author(s):  
Riya Mukherjee ◽  
Nicola E. Brasch
Keyword(s):  
Nitrogen Dioxide ◽  
Dual Role ◽  
Peroxynitrous Acid ◽  
Mechanistic Studies

Rongalite-Induced Transition-Metal and Hydride-Free Reductive Aldol Reaction: A Rapid access to 3,3´- Disubstituted Oxindoles and Its Mechanistic Studies

2022 ◽  
Author(s):  
Sivaparwathi Golla ◽  
Naveenkumar Anugu ◽  
Swathi Jalagam ◽  
Hari Prasad Kokatla
Keyword(s):  
Transition Metal ◽  
Aldol Reaction ◽  
Dual Role ◽  
Biologically Active ◽  
Mechanistic Studies ◽  
Rapid Access ◽  
Reductive Aldol ◽  
Isatin Derivatives

A transition-metal and hydride-free reductive aldol reaction has been developed for the synthesis of biologically active 3,3´-disubstituted oxindoles from isatin-derivatives using rongalite. In this protocol, rongalite plays the dual role...

Dual role of carboxylic acid additive: mechanistic studies and implication for the asymmetric C–H amidation

Tetrahedron ◽  
2015 ◽  
Vol 71 (26-27) ◽  
pp. 4504-4511 ◽  
Author(s):  
Donghyeon Gwon ◽  
Sehoon Park ◽  
Sukbok Chang
Keyword(s):  
Carboxylic Acid ◽  
Dual Role ◽  
Mechanistic Studies

scholarly journals Molecular Complexes for Effective Inhibition of Tau Aggregation

2018 ◽  
Author(s):  
Nalini V. Gorantla ◽  
Vinod G. Landge ◽  
Pramod G. Nagaraju ◽  
Lisni P. Sunny ◽  
Anjhu Nair ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Conformational Changes ◽  
Molecular Complexes ◽  
Dual Role ◽  
Mechanistic Studies ◽  
Contemporary Science ◽  
Effective Inhibition ◽  
Axonal Protein ◽  
Tau Aggregation

ABSTRACTTau is an axonal protein known to form abnormal aggregates and is the biomarker of Alzheimer’s disease. Metal-based therapeutics for inhibition of Tau aggregation is limited and rarely reported in the contemporary science. Here, the first example is reported of a rationally designed molecular cobalt(II)-complexes for effective inhibition of Tau and disaggregation of preformed Tau fibrils. The mechanistic studies revealed that the prevention of Tau aggregation by CBMCs is concentration-dependent and Tau seldom exhibits conformational changes. Interestingly, CBMCs play a dual role by causing disassembly of preformed aggregates as well as complete Tau inhibition. We believe that this unprecedented finding by the newly developed molecular complexes has a potential to lead to developing innovative metal-based therapeutics for Alzheimer’s disease.

β-Carotene effectively scavenges toxic nitrogen oxides: nitrogen dioxide and peroxynitrous acid

FEBS Letters ◽  
1997 ◽  
Vol 404 (2-3) ◽  
pp. 175-178 ◽  
Author(s):  
Kiyomi Kikugawa ◽  
Kazuyuki Hiramoto ◽  
Susumu Tomiyama ◽  
Yoshiko Asano
Keyword(s):  
Nitrogen Oxides ◽  
Nitrogen Dioxide ◽  
Peroxynitrous Acid ◽  
Β Carotene

Copper-Catalyzed Oxidative Synthesis of α-Ketoamides from Aryl Methyl Ketones and N-Bromobutanimide Using N,N-Dimethylformamide as Dimethylamine Source

Synlett ◽  
2020 ◽  
Vol 31 (04) ◽  
pp. 393-397 ◽  
Author(s):  
Ying Wei ◽  
Yongxia Yan ◽  
Xiaoyan Li
Keyword(s):  
Acid Hydrolysis ◽  
Dual Role ◽  
Methyl Ketones ◽  
Mechanistic Studies ◽  
Mild Conditions ◽  
Aryl Methyl

A novel and practical Cu(OAc)2-catalyzed oxidative synthesis of α-ketoamides from aryl methyl ketones and N-bromobutanimide (NBS) using N,N-dimethylformamide (DMF) as dimethylamine (HNMe2) source and solvent has been developed under mild conditions. DMF was used as a HNMe2 source and can be easily converted into HNMe2 by acid hydrolysis. The mechanistic studies indicate that Cu(OAc)2 plays a dual role in providing both catalyst and oxidant.

Mechanistic Studies of a Pd-Catalyzed Direct Arylation En Route to Beclabuvir: Dual Role of a Tetramethylammonium Cation and an Unusual Turnover-Limiting Step

ACS Catalysis ◽  
2021 ◽  
pp. 2460-2472
Author(s):  
Chao Hang ◽  
Antonio Ramirez ◽  
Collin Chan ◽  
Yi Hsiao ◽  
Albert J. DelMonte ◽  
...  
Keyword(s):  
Dual Role ◽  
Mechanistic Studies ◽  
Direct Arylation ◽  
Limiting Step

Effect of β-carotene on the transformation of tyrosine by nitrogen dioxide and peroxynitrous acid

1999 ◽  
Vol 30 (1) ◽  
pp. 37-43 ◽  
Author(s):  
Kiyomi Kikugawa ◽  
Kazuyuki Hiramoto ◽  
Susumu Tomiyama ◽  
Kazuya Nakauchi
Keyword(s):  
Nitrogen Dioxide ◽  
Peroxynitrous Acid ◽  
Β Carotene

The Effect of Vitamin A on the Intermittent Nitrogen Dioxide Gas Exposure in Hamsters

1976 ◽  
Vol 34 ◽  
pp. 176-177
Author(s):  
J.C.S. Kim ◽  
M.G. Jourden ◽  
E.S. Carlisle
Keyword(s):  
Electron Microscopy ◽  
Vitamin A ◽  
Nitrogen Dioxide ◽  
Chronic Exposure ◽  
Light And Electron Microscopy ◽  
Specific Effect ◽  
Deficient Diet ◽  
Intermittent Exposure ◽  
Hypovitaminosis A ◽  
Gas Exposure

Chronic exposure to nitrogen dioxide in rodents has shown that injury reaches a maximum after 24 hours, and a reparative adaptive phase follows (1). Damage occurring in the terminal bronchioles and proximal portions of the alveolar ducts in rats has been extensively studied by both light and electron microscopy (1).The present study was undertaken to compare the response of lung tissue to intermittent exposure to 10 ppm of nitrogen dioxide gas for 4 hours per week, while the hamsters were on a vitamin A deficient diet. Ultrastructural observations made from lung tissues obtained from non-gas exposed, hypovitaminosis A animals and gas exposed animals fed a regular commercially prepared diet have been compared to elucidate the specific effect of vitamin A on nitrogen dioxide gas exposure. The interaction occurring between vitamin A and nitrogen dioxide gas has not previously been investigated.

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