scholarly journals Noncovalent Isotope Effect for Guest Encapsulation in Self-Assembled Molecular Capsules

2010 ◽  
Vol 16 (4) ◽  
pp. 1100-1100
Author(s):  
Takeharu Haino ◽  
Katsunori Fukuta ◽  
Hajime Iwamoto ◽  
Suehiro Iwata
Keyword(s):  
Isotope Effect ◽  
Molecular Capsules ◽  
Self Assembled

Noncovalent Isotope Effect for Guest Encapsulation in Self-Assembled Molecular Capsules

2009 ◽  
Vol 15 (48) ◽  
pp. 13286-13290 ◽  
Author(s):  
Takeharu Haino ◽  
Katsunori Fukuta ◽  
Hajime Iwamoto ◽  
Suehiro Iwata
Keyword(s):  
Isotope Effect ◽  
Molecular Capsules ◽  
Self Assembled

scholarly journals Molecular Capsule Catalysis: Ready to Address Current Challenges in Synthetic Organic Chemistry?

2020 ◽  
Vol 74 (7) ◽  
pp. 561-568
Author(s):  
Ivana Némethová ◽  
Leonidas-Dimitrios Syntrivanis ◽  
Konrad Tiefenbacher
Keyword(s):  
Organic Chemistry ◽  
Building Blocks ◽  
Short Article ◽  
Molecular Capsules ◽  
Synthetic Organic Chemistry ◽  
Size And Shape ◽  
Molecular Capsule ◽  
Hydrophobic Binding ◽  
Binding Pockets ◽  
Self Assembled

Self-assembled molecular capsules, host structures that form spontaneously when their building blocks are mixed, have been known since the 1990s. They share some basic similarities with enzyme pockets, as they feature defined hydrophobic binding pockets that are able to bind molecules of appropriate size and shape. The potential to utilize such host structures for catalysis has been explored since their discovery; however, applications that solve current challenges in synthetic organic chemistry have remained limited. In this short article, we discuss the challenges associated with the use of molecular capsules as catalysts, and highlight some recent applications of supramolecular capsules to overcome challenges in synthetic organic chemistry.

ChemInform Abstract: Advantages of Catalysis in Self-Assembled Molecular Capsules

ChemInform ◽  
2016 ◽  
Vol 47 (35) ◽  
Author(s):  
Lorenzo Catti ◽  
Qi Zhang ◽  
Konrad Tiefenbacher
Keyword(s):  
Molecular Capsules ◽  
Self Assembled

Self-Assembled Molecular Capsules for C70 Separation

Synfacts ◽  
2007 ◽  
Vol 2007 (3) ◽  
pp. 0275-0275
Author(s):  
J. de Mendoza ◽  
E. Huerta ◽  
G. Metselaar ◽  
A. Fragoso ◽  
E. Santos ◽  
...  
Keyword(s):  
Molecular Capsules ◽  
Self Assembled

Advantages of Catalysis in Self-Assembled Molecular Capsules

2016 ◽  
Vol 22 (27) ◽  
pp. 9060-9066 ◽  
Author(s):  
Lorenzo Catti ◽  
Qi Zhang ◽  
Konrad Tiefenbacher
Keyword(s):  
Molecular Capsules ◽  
Self Assembled

scholarly journals H/D Isotope Effects on Redox-Switching of DNA Self-Assembled Monolayers Observed by EQCM and Cyclic Voltammetry

2018 ◽  
Author(s):  
Sarasi K. K. Galagedera ◽  
Gerd-Uwe Flechsig
Keyword(s):  
Isotope Effect ◽  
Drug Testing ◽  
Deuterium Oxide ◽  
Isotope Effects ◽  
Electrochemical Quartz Crystal Microbalance ◽  
Reaction Rate Constant ◽  
Reduction Peak ◽  
Buffer Medium ◽  
Self Assembled ◽  
Redox Switching

An electrochemical quartz crystal microbalance (EQCM) was employed to study the interactions of hexammine ruthenium(III) (RuHex) and hexammine cobalt(III) (CoHex) with a mixed self-assembled monolayer of single-stranded DNA and 6-mercapto-1-hexanol (ssDNA/MCH SAM) immobilized on gold electrodes. When the buffer medium was switched to deuterium oxide (D<sub>2</sub>O) from normal water (H<sub>2</sub>O), we observed a pronounced H/D kinetic isotope effect where a consistent shift of up to 400 mV was seen for the reduction peak potential of CoHex but not with RuHex. This was attributed to a 2400-fold change of the apparent reaction rate constant. Though there was a dramatic increase in the EQCM frequency response at a millisecond time scale in the presence of both redox indicators, compared to the signal observed in a low ionic strength buffer (10 mM tris(hydroxymethyl)aminomethane (Tris)/H<sub>2</sub>SO<sub>4 </sub>at pH 7.5), a 10 Hz decrease in the frequency shift was observed upon switching from H<sub>2</sub>O to D<sub>2</sub>O-based buffer medium. The hydrogen bond network within the ssDNA layer seems to amplify the H/D isotope effect with CoHex. Amplified isotope effects may play a role in living systems. The mechanisms of recently reported H/D isotope effects in medicinal and biochemistry are still widely unclear. Voltammetric and EQCM studies of H/D isotope effects can provide a platform to investigate amplified isotope effects not only with DNA layers, but probably also with proteins and small organic molecules and may be useful for studies of cell proliferation, as well as drug testing.

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