Synthesis of Small Molecules with High Scaffold Diversity: Exploitation of Metathesis Cascades in Combination with Inter- and Intramolecular Diels-Alder Reactions

2010 ◽  
Vol 16 (31) ◽  
pp. 9563-9571 ◽  
Author(s):  
Catherine O'Leary-Steele ◽  
Palle J. Pedersen ◽  
Thomas James ◽  
Thomas Lanyon-Hogg ◽  
Stuart Leach ◽  
...  
Keyword(s):  
Small Molecules ◽  
Diels Alder ◽  
Scaffold Diversity

ChemInform Abstract: Synthesis of Small Molecules with High Scaffold Diversity: Exploitation of Metathesis Cascades in Combination with Inter- and Intramolecular Diels-Alder Reactions.

ChemInform ◽  
2010 ◽  
Vol 42 (2) ◽  
pp. no-no
Author(s):  
Catherine O'Leary-Steele ◽  
Palle J. Pedersen ◽  
Thomas James ◽  
Thomas Lanyon-Hogg ◽  
Stuart Leach ◽  
...  
Keyword(s):  
Small Molecules ◽  
Diels Alder ◽  
Scaffold Diversity

Asymmetric Synthesis of 3,3′-Piperidinoyl Spirooxindoles and Discovery of Stereospecific Cycloadducts as Novel Hedgehog Pathway Modulators

Synthesis ◽  
2020 ◽  
Vol 52 (21) ◽  
pp. 3140-3152
Author(s):  
Kamal Kumar ◽  
Mohammad Rehan ◽  
Jana Flegel ◽  
Franziska Heitkamp ◽  
Jorgelina L. Pergomet ◽  
...  
Keyword(s):  
Transition Metal ◽  
Small Molecules ◽  
Asymmetric Synthesis ◽  
Natural Product ◽  
Transition Metal Complexes ◽  
Alder Reaction ◽  
Diels Alder ◽  
Hedgehog Pathway ◽  
Diels Alder Reaction ◽  
Efficient Access

An enantioselective hetero-Diels–Alder reaction of alkylidene­ oxindoles and 2-aza-3-silyloxy-1,3-butadienes, catalyzed by divalent transition metal complexes with N,N′-dioxide ligands offered an efficient access to natural-product-based 3,3′-piperidinoyl spiroox­indole class of small molecules. exo-Cycloadducts formed via stereospecific cycloaddition with Z-olefin displayed potent activity in modulation of hedgehog pathway.

Organocatalytic Sequential Hetero-Diels–Alder and Friedel–Crafts Reaction: Constructions of Fused Heterocycles with Scaffold Diversity

2011 ◽  
Vol 13 (21) ◽  
pp. 5874-5877 ◽  
Author(s):  
Si-Li Zhou ◽  
Jun-Long Li ◽  
Lin Dong ◽  
Ying-Chun Chen
Keyword(s):  
Diels Alder ◽  
Fused Heterocycles ◽  
Scaffold Diversity

Structural Diversity Attributed by Aza-Diels-Alder Reaction in Synthesis of Diverse Quinoline Scaffolds

2019 ◽  
Vol 23 (8) ◽  
pp. 920-958 ◽  
Author(s):  
Dharmender Singh ◽  
Vipin Kumar ◽  
Chandi C. Malakar ◽  
Virender Singh
Keyword(s):  
Structural Diversity ◽  
Alder Reaction ◽  
Diels Alder ◽  
Protein Targets ◽  
Feasible Method ◽  
Diels Alder Reaction ◽  
Scaffold Diversity ◽  
Synthetic Chemist

In recent years, the synthesis of quinoline scaffold using various methodological devices has attracted considerable attention in synthetic chemist community. The most feasible method to serve this purpose is Aza-Diels-Alder reaction which provides flexibility and diversity in the synthesis of quinoline decorated with different functionalities over the scaffold. Diversity in this functionality improvises the susceptibility of the quinoline scaffold for various protein targets. This review encompasses multifactorial aspects of Aza-Diels-Alder reaction as well as provides insights into the synthetic schemes for quinoline scaffold.

Gap junctions in the prothoracic glands of the tobacco hornworm, Manduca sexta

1992 ◽  
Vol 50 (1) ◽  
pp. 706-707
Author(s):  
Ji-da Dai ◽  
M. Joseph Costello ◽  
Lawrence I. Gilbert
Keyword(s):  
Gap Junctions ◽  
Small Molecules ◽  
Manduca Sexta ◽  
Freeze Fracture ◽  
Cell Communication ◽  
Cellular Level ◽  
Thin Sections ◽  
Prothoracic Glands ◽  
Polyhydroxylated Steroids ◽  
Stimulation Of

Insect molting and metamorphosis are elicited by a class of polyhydroxylated steroids, ecdysteroids, that originate in the prothoracic glands (PGs). Prothoracicotropic hormone stimulation of steroidogenesis by the PGs at the cellular level involves both calcium and cAMP. Cell-to-cell communication mediated by gap junctions may play a key role in regulating signal transduction by controlling the transmission of small molecules and ions between adjacent cells. This is the first report of gap junctions in the PGs, the evidence obtained by means of SEM, thin sections and freeze-fracture replicas.

Fusion and Fission Processes in Exocytosis: Possible Roles for Synexin and Osmotic Lysis in the Two Events

1980 ◽  
Vol 38 ◽  
pp. 594-597
Author(s):  
H.B. Pollard ◽  
C.E. Creutz ◽  
C.J. Pazoles ◽  
J.H. Scott
Keyword(s):  
Small Molecules ◽  
Chromaffin Cells ◽  
Adrenal Glands ◽  
General Concept ◽  
Extracellular Calcium ◽  
Large Protein ◽  
Granule Membrane ◽  
Osmotic Lysis ◽  
Per Se ◽  
Chemical Evidence

Exocytosis is a general concept describing secretion of enzymes, hormones and transmitters that are otherwise sequestered in intracellular granules. Chemical evidence for this concept was first gathered from studies on chromaffin cells in perfused adrenal glands, in which it was found that granule contents, including both large protein and small molecules such as adrenaline and ATP, were released together while the granule membrane was retained in the cell. A number of exhaustive reviews of this early work have been published and are summarized in Reference 1. The critical experiments demonstrating the importance of extracellular calcium for exocytosis per se were also first performed in this system (2,3), further indicating the substantial service given by chromaffin cells to those interested in secretory phenomena over the years.

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