The Unusual Nucleotide Recognition Properties of the Resistance Enzyme ANT(4′): Inorganic Tri/Polyphosphate as a Substrate for Aminoglycoside Inactivation

2010 ◽  
Vol 16 (29) ◽  
pp. 8635-8640 ◽  
Author(s):  
Julia Revuelta ◽  
Francisco Corzana ◽  
Agatha Bastida ◽  
Juan Luis Asensio
Keyword(s):  
Nucleotide Recognition

The first 3′:5′-cyclic nucleotide–amino acid complex:L-His–cIMP

2012 ◽  
Vol 68 (8) ◽  
pp. o311-o316 ◽  
Author(s):  
Katarzyna Ślepokura
Keyword(s):  
Crystal Structure ◽  
Amino Acid ◽  
Cyclic Nucleotide ◽  
Phosphate Group ◽  
Specific Amino Acid ◽  
Π Stacking ◽  
Cyclic Phosphate ◽  
Nucleotide Recognition ◽  
Group Play ◽  
Phosphate Groups

In the crystal structure of the L-His–cIMP complex,i.e.L-histidinium inosine 3′:5′-cyclic phosphate [systematic name: 5-(2-amino-2-carboxyethyl)-1H-imidazol-3-ium 7-hydroxy-2-oxo-6-(6-oxo-6,9-dihydro-1H-purin-9-yl)-4a,6,7,7a-tetrahydro-4H-1,3,5,2λ5-furo[3,2-d][1,3,2λ5]dioxaphosphinin-2-olate], C6H10N3O2+·C10H10N4O7P−, the Hoogsteen edge of the hypoxanthine (Hyp) base of cIMP and the Hyp face are engaged in specific amino acid–nucleotide (His...cIMP) recognition,i.e.by abutting edge-to-edge and by π–π stacking, respectively. The Watson–Crick edge of Hyp and the cIMP phosphate group play a role in nonspecific His...cIMP contacts. The interactions between the cIMP anions (anti/C3′–endo/trans–gauche/chair conformers) are realized mainly between riboses and phosphate groups. The results for this L-His–cIMP complex, compared with those for the previously reported solvated L-His–IMP crystal structure, indicate a different nature of amino acid–nucleotide recognition and interactions upon the 3′:5′-cyclization of the nucleotide phosphate group.

scholarly journals Mechanical tuning of molecular machines for nucleotide recognition at the air-water interface

2011 ◽  
Vol 6 (1) ◽  
pp. 304 ◽  
Author(s):  
Taizo Mori ◽  
Ken Okamoto ◽  
Hiroshi Endo ◽  
Keita Sakakibara ◽  
Jonathan P Hill ◽  
...  
Keyword(s):  
Molecular Machines ◽  
Water Interface ◽  
Air Water Interface ◽  
Nucleotide Recognition ◽  
Mechanical Tuning

Mutants Affecting Nucleotide Recognition by T7 DNA Polymerase

Biochemistry ◽  
1994 ◽  
Vol 33 (49) ◽  
pp. 14908-14917 ◽  
Author(s):  
Maureen J. Donlin ◽  
Kenneth A. Johnson
Keyword(s):  
Dna Polymerase ◽  
Nucleotide Recognition

Mouse ascites DNA methylase: characterisation of size, proteolytic breakdown and nucleotide recognition

1986 ◽  
Vol 868 (1) ◽  
pp. 9-16 ◽  
Author(s):  
R.L.P. Adams ◽  
K. Gardiner ◽  
A. Rinaldi ◽  
M. Bryans ◽  
M. McGarvey ◽  
...  
Keyword(s):  
Dna Methylase ◽  
Mouse Ascites ◽  
Nucleotide Recognition

scholarly journals Erratum: Corrigendum: Nucleotide recognition by the cytoplasmic domain of the human chloride transporter ClC-5

2007 ◽  
Vol 14 (2) ◽  
pp. 172-172
Author(s):  
Sebastian Meyer ◽  
Sara Savaresi ◽  
Ian C Forster ◽  
Raimund Dutzler
Keyword(s):  
Cytoplasmic Domain ◽  
Nucleotide Recognition

Adenine nucleotide recognition by spiramycin and some of its aromatic derivatives

2016 ◽  
Vol 86 (3-4) ◽  
pp. 211-219 ◽  
Author(s):  
Karla Isabel Rivera-Márquez ◽  
Carolina Godoy-Alcántar ◽  
Miguel Ángel Claudio-Catalán ◽  
Felipe Medrano
Keyword(s):  
Adenine Nucleotide ◽  
Nucleotide Recognition
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