Cooperative Acid-Base Effects with Functionalized Mesoporous Silica Nanoparticles: Applications in Carbon-Carbon Bond-Formation Reactions

2009 ◽  
Vol 15 (29) ◽  
pp. 7052-7062 ◽  
Author(s):  
Sankaranarayanapillai Shylesh ◽  
Alex Wagner ◽  
Andreas Seifert ◽  
Stefan Ernst ◽  
Werner R. Thiel
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Bond Formation ◽  
Acid Base ◽  
Carbon Bond ◽  
Functionalized Mesoporous Silica ◽  
Carbon Carbon Bond ◽  
Bond Formation Reactions

scholarly journals Pd@Py2PZ@MSN as a Novel and Efficient Catalyst for C-C Bond Formation Reactions

2021 ◽  
Author(s):  
Mohammad Hossein Sayahi ◽  
Mansoureh Toosibashi ◽  
Mehdi Bahmaei ◽  
Hosein Lijan ◽  
Leila Maˈmani ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Bond Formation ◽  
Significant Loss ◽  
Efficient Catalyst ◽  
Simple Method ◽  
Carbon Carbon Bond ◽  
Novel Catalyst ◽  
Bond Formation Reactions

Abstract In this paper, a novel catalyst is introduced based on the immobilization of palladium onto dipyrido[3,2-a:2',3'-c]phenazine modified mesoporous silica nanoparticles. Dipyrido[3,2-a:2',3'-c]phenazine (Py2PZ) ligand is synthesized in a simple method from the reaction of 1,10-phenanthroline-5,6-dione and 3,4-diaminobenzoic acid as starting materials. The ligand is used to functionalize mesoporous silica nanoparticles (MSN) and to modify its surface chemistry for immobilization of palladium. The palladium immobilized dipyrido[3,2-a:2',3'-c]phenazine modified mesoporous silica nanoparticles (Pd@Py2PZ@MSN) are synthesized and characterized by several characterization techniques, including TEM, SEM, FTIR, TGA, ICP, XRD, and EDS analysis. After the careful characterization of Pd@Py2PZ@MSN, the activity and efficiency of this catalyst is examined in carbon-carbon bond formation reactions. The results are advantageous in water and the products are obtained in high isolated yields. In addition, the catalyst shows very good reusability and did not show significant loss in activity after 10 sequential runs.

Curcumin-Loaded Amine-Functionalized Mesoporous Silica Nanoparticles Inhibit α-Synuclein Fibrillation and Reduce Its Cytotoxicity-Associated Effects

Langmuir ◽  
2016 ◽  
Vol 32 (50) ◽  
pp. 13394-13402 ◽  
Author(s):  
Nayere Taebnia ◽  
Dina Morshedi ◽  
Soheila Yaghmaei ◽  
Farhang Aliakbari ◽  
Fatemeh Rahimi ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Functionalized Mesoporous Silica ◽  
Amine Functionalized

scholarly journals Isolation and Quantification of miRNA from the Biomolecular Corona on Mesoporous Silica Nanoparticles

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1196
Author(s):  
Carla Vidaurre-Agut ◽  
Eva María Rivero-Buceta ◽  
Christopher C. Landry ◽  
Pablo Botella
Keyword(s):  
Prostate Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Incubation Temperature ◽  
Mesoporous Silica Nanoparticles ◽  
Nanoparticle Concentration ◽  
Functionalized Mesoporous Silica ◽  
Amine Functionalized ◽  
Commercial Kit ◽  
Higher Sensitivity

To understand the factors that control the formation of the biomolecular corona, a systematic study of the adsorption of several miRNAs shown to be important in prostate cancer on amine-functionalized mesoporous silica nanoparticles (MSN-NH2) has been performed. Process parameters including miRNA type, nanoparticle concentration, incubation temperature and incubation time were investigated, as well as the potential competition for adsorption between different miRNA molecules. The influence of proteins and particle PEGylation on miRNA adsorption were also explored. We found that low particle concentrations and physiological temperature both led to increased miRNA adsorption. Adsorption of miRNA was also higher when proteins were present in the same solution; reducing or preventing protein adsorption by PEGylating the MSNs hindered adsorption. Finally, the amount of miRNA adsorbed from human serum by MSN-NH2 was compared to a commercial miRNA purification kit (TaqMan®, Life Technologies, Carlsbad, CA, USA). MSN-NH2 adsorbed six times as much miRNA as the commercial kit, demonstrating higher sensitivity to subtle up- and downregulation of circulating miRNA in the blood of patients.

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