The Binding Mode of Petrosaspongiolide M to the Human Group IIA Phospholipase A2: Exploring the Role of Covalent and Noncovalent Interactions in the Inhibition Process

2008 ◽  
Vol 15 (5) ◽  
pp. 1155-1163 ◽  
Author(s):  
Maria Chiara Monti ◽  
Agostino Casapullo ◽  
Claudio N. Cavasotto ◽  
Alessandra Tosco ◽  
Fabrizio Dal Piaz ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Noncovalent Interactions ◽  
Binding Mode ◽  
Human Group ◽  
Inhibition Process ◽  
Group Iia Phospholipase A2

The Binding Mode of Cladocoran A to the Human Group IIA Phospholipase A2

ChemBioChem ◽  
2011 ◽  
Vol 12 (17) ◽  
pp. 2686-2691 ◽  
Author(s):  
Maria Chiara Monti ◽  
Maria Giovanna Chini ◽  
Luigi Margarucci ◽  
Raffaele Riccio ◽  
Giuseppe Bifulco ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Binding Mode ◽  
Human Group ◽  
Group Iia Phospholipase A2

Inside Cover: The Binding Mode of Cladocoran A to the Human Group IIA Phospholipase A2 (ChemBioChem 17/2011)

ChemBioChem ◽  
2011 ◽  
Vol 12 (17) ◽  
pp. 2522-2522
Author(s):  
Maria Chiara Monti ◽  
Maria Giovanna Chini ◽  
Luigi Margarucci ◽  
Raffaele Riccio ◽  
Giuseppe Bifulco ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Binding Mode ◽  
Human Group ◽  
Group Iia Phospholipase A2

scholarly journals Role of human group IIA secreted phospholipase A2 in malaria pathophysiology: Insights from a transgenic mouse model

Biochimie ◽  
2021 ◽  
Author(s):  
Mélanie Dacheux ◽  
Soraya Chaouch ◽  
Alonso Joy ◽  
Amandine Labat ◽  
Christine Payré ◽  
...  
Keyword(s):  
Mouse Model ◽  
Phospholipase A2 ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Human Group ◽  
Secreted Phospholipase A2

scholarly journals The Role of Propeptide in the Refolding of Human Group IB Phospholipase A2

2004 ◽  
Vol 36 (9) ◽  
pp. 583-588 ◽  
Author(s):  
Hong-Qiang Cheng ◽  
Gen-Jun Xu
Keyword(s):  
Light Scattering ◽  
Phospholipase A2 ◽  
Disulfide Bonds ◽  
Human Group ◽  
Terminal Sequence ◽  
E Coli ◽  
Mature Enzyme

Abstract Human group IB phospholipase A2 (IB-PLA2) and its zymogen (proIB-PLA2) were purified from E. coli. Refolding was carried out by diluting the denatured forms of both IB-PLA2 and proIB-PLA2 with renaturation buffer in which the disulfide bonds were completely reduced. The refolding yield of proIB-PLA2 was increased by about 50% over that of the mature enzyme. The refolding of IB-PLA2 usually produced aggregates under normal conditions, as determined by light scattering. In addition, the unfolding experiments showed that the mature enzyme was more stable than the proenzyme toward denaturants in the presence of DTT. Results suggested that the N-terminal sequence rather than its conformation of human proIB-PLA2 played an important role in the refolding process.

Acute Pancreatitis in Transgenic Mice Expressing Human Group IIA Phospholipase A2

Pancreas ◽  
2002 ◽  
Vol 25 (2) ◽  
pp. 188-191 ◽  
Author(s):  
Jens M. Mayer ◽  
V. Jukka O. Laine ◽  
Susanne Kolodziej ◽  
Timo J. Nevalainen ◽  
Hans G. Beger
Keyword(s):  
Acute Pancreatitis ◽  
Transgenic Mice ◽  
Phospholipase A2 ◽  
Human Group ◽  
Group Iia Phospholipase A2

Effect of Tryptophan Insertions on the Properties of the Human Group IIA Phospholipase A2:  Mutagenesis Produces an Enzyme with Characteristics Similar to Those of the Human Group V Phospholipase A2†

Biochemistry ◽  
2003 ◽  
Vol 42 (24) ◽  
pp. 7326-7338 ◽  
Author(s):  
Stephen A. Beers ◽  
Andrew G. Buckland ◽  
Niroshini Giles ◽  
Michael H. Gelb ◽  
David C. Wilton
Keyword(s):  
Phospholipase A2 ◽  
Human Group ◽  
Group V ◽  
Group Iia Phospholipase A2

ExperimentalHelicobacter felisInfection in Transgenic Mice Expressing Human Group IIA Phospholipase A2

Helicobacter ◽  
2004 ◽  
Vol 9 (5) ◽  
pp. 408-416 ◽  
Author(s):  
Heikki T. Huhtinen ◽  
Juha M. Grönroos ◽  
Jaakko Uksila ◽  
David S. Grass ◽  
Timo J. Nevalainen ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Phospholipase A2 ◽  
Human Group ◽  
Group Iia Phospholipase A2

Suramin inhibits macrophage activation by human group IIA phospholipase A2, but does not affect bactericidal activity of the enzyme

2009 ◽  
Vol 58 (4) ◽  
pp. 210-217 ◽  
Author(s):  
E. A. Aragão ◽  
L. Chioato ◽  
T. L. Ferreira ◽  
A. I. de Medeiros ◽  
A. Secatto ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Bactericidal Activity ◽  
Macrophage Activation ◽  
Human Group ◽  
Group Iia Phospholipase A2
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