One-Pot Three-Component Catalytic Synthesis of Fully Substituted Pyrroles from Readily Available Propargylic Alcohols, 1,3-Dicarbonyl Compounds and Primary Amines

2007 ◽  
Vol 13 (35) ◽  
pp. 9973-9981 ◽  
Author(s):  
Victorio Cadierno ◽  
José Gimeno ◽  
Noel Nebra
Keyword(s):  
Catalytic Synthesis ◽  
Primary Amines ◽  
One Pot ◽  
Dicarbonyl Compounds ◽  
Propargylic Alcohols ◽  
Substituted Pyrroles

scholarly journals Synthesis of Pentasubstituted 2-Aryl Pyrroles from Boryl and Stannyl Alkynes via One-Pot Sequential Ti-Catalyzed [2+2+1] Pyrrole Synthesis/Cross Coupling Reactions

2020 ◽  
Author(s):  
Yukun Cheng ◽  
Channing Klein ◽  
Ian Tonks
Keyword(s):  
Cross Coupling ◽  
Catalytic Synthesis ◽  
Coupling Reactions ◽  
One Pot ◽  
Suzuki Reactions ◽  
Cross Coupling Reactions ◽  
Substituted Pyrroles

<div> <div> <div> <div> <p>An efficient catalytic synthesis of 2-heteroatom-substituted (9-BBN or SnR3) pyrroles via Ti-catalyzed [2+2+1] heterocoupling of heteroatom-substituted alkynes is reported. The resulting 2-boryl substituted pyrroles can then be used in Suzuki reactions in a 1-pot sequential fashion, resulting in pentasubstituted 2-aryl pyrroles that are inaccessible via previous [2+2+1] heterocoupling strategies. </p> </div> </div> </div> </div>

Direct catalytic synthesis of β-(C3)-substituted pyrroles: a complementary addition to the Paal–Knorr reaction

2021 ◽  
Vol 57 (2) ◽  
pp. 251-254
Author(s):  
Amol Prakash Pawar ◽  
Jyothi Yadav ◽  
Nisar Ahmad Mir ◽  
Eldhose Iype ◽  
Krishnan Rangan ◽  
...  
Keyword(s):  
Dft Calculations ◽  
Catalytic Synthesis ◽  
Primary Amines ◽  
Multicomponent Synthesis ◽  
Mild Conditions ◽  
Substituted Pyrroles ◽  
High Yields

Direct catalytic multicomponent synthesis of β-(C3)-substituted pyrroles is developed with good to high yields, using aqueous succinaldehyde, primary amines, and isatins under mild conditions. An access to the β-substituted free NH-pyrrole is the main focus of the work along with DFT-calculations.

One-pot three-component reaction of ninhydrin, 1,3-dicarbonyl compounds, and primary amines to afford indeno[1,2-b]pyrrol-4(1H)-ones

2018 ◽  
Vol 54 (11) ◽  
pp. 1040-1044 ◽  
Author(s):  
Hossein Karami ◽  
Zinatossadat Hossaini ◽  
Maryam Sabbaghan ◽  
Faramarz Rostami-Charati
Keyword(s):  
Primary Amines ◽  
One Pot ◽  
Dicarbonyl Compounds ◽  
Three Component Reaction
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