Design and Synthesis of Novel Propellanes by Using Claisen Rearrangement and Ring-Closing Metathesis as the Key Steps

2006 ◽  
Vol 12 (16) ◽  
pp. 4446-4450 ◽  
Author(s):  
Sambasivarao Kotha ◽  
Mirtunjay Kumar Dipak
Keyword(s):  
Claisen Rearrangement ◽  
Ring Closing Metathesis ◽  
Design And Synthesis ◽  
Key Steps

scholarly journals Design and synthesis of hybrid cyclophanes containing thiophene and indole units via Grignard reaction, Fischer indolization and ring-closing metathesis as key steps

2015 ◽  
Vol 11 ◽  
pp. 1514-1519 ◽  
Author(s):  
Sambasivarao Kotha ◽  
Ajay Kumar Chinnam ◽  
Mukesh Eknathrao Shirbhate
Keyword(s):  
Grignard Reaction ◽  
Ring Closing Metathesis ◽  
Design And Synthesis ◽  
Synthetic Strategy ◽  
Fischer Indolization ◽  
Grignard Addition ◽  
Key Steps

We demonstrate a new synthetic strategy to cyclophanes containing thiophene and indole moieties via Grignard addition, Fischer indolization and ring-closing metathesis as key steps.

Ring-Closing Metathesis Approach to Cage Propellanes Containing Oxepane and Tetrahydrofuran Hybrid System

Synthesis ◽  
2017 ◽  
Vol 49 (24) ◽  
pp. 5339-5350 ◽  
Author(s):  
Sambasivarao Kotha ◽  
Subba Cheekatla ◽  
Darshan Mhatre
Keyword(s):  
Claisen Rearrangement ◽  
Alder Reaction ◽  
Diels Alder ◽  
Ring Closing Metathesis ◽  
Cage Compounds ◽  
Transannular Cyclization ◽  
Diels Alder Reaction ◽  
Grignard Addition ◽  
Key Steps ◽  
First Time

The preparation of a variety of structurally interesting oxygenated cage compounds involving atom-economic processes such as Claisen rearrangement, Diels–Alder reaction, [2+2] photocycloaddition, and ring-closing metathesis (RCM) as key steps is reported. For the first time, oxepane ring system is introduced in cage framework using olefin metathesis as a key step. These cage systems assembled here are difficult to prepare by traditional methods. The synthetic sequence described here opens up new routes to higher order polycycles containing heteroatoms without the involvement of protecting groups. Transannular cyclization observed during Grignard addition and the RCM protocol used here may be applicable to generate unknown oxygenated cage systems.

scholarly journals Design and synthesis of C 3-symmetric molecules bearing propellane moieties via cyclotrimerization and a ring-closing metathesis sequence

2018 ◽  
Vol 14 ◽  
pp. 2537-2544 ◽  
Author(s):  
Sambasivarao Kotha ◽  
Saidulu Todeti ◽  
Vikas R Aswar
Keyword(s):  
Benzene Ring ◽  
Alder Reaction ◽  
Diels Alder ◽  
Central Core ◽  
Ring Closing Metathesis ◽  
Design And Synthesis ◽  
Synthetic Strategy ◽  
Diels Alder Reaction ◽  
End Groups ◽  
Key Steps

We have developed an efficient synthetic strategy to assemble C 3-symmetric molecules containing propellane moieties as end groups and a benzene ring as a central core. The synthesis of these C 3-symmetric molecules involves simple starting materials. Our approach to C 3-symmetric compounds relies on a Diels–Alder reaction, cyclotrimerization and ring-closing metathesis as key steps.

Design and synthesis of polycyclic bisindoles via Fischer indolization and ring-closing metathesis as key steps

2016 ◽  
Vol 57 (50) ◽  
pp. 5605-5607 ◽  
Author(s):  
Sambasivarao Kotha ◽  
Subba Rao Cheekatla ◽  
Ajay Kumar Chinnam ◽  
Tanu Jain
Keyword(s):  
Ring Closing Metathesis ◽  
Design And Synthesis ◽  
Fischer Indolization ◽  
Key Steps

scholarly journals Design and synthesis of novel bis-annulated caged polycycles via ring-closing metathesis: pushpakenediol

2014 ◽  
Vol 10 ◽  
pp. 2664-2670 ◽  
Author(s):  
Sambasivarao Kotha ◽  
Mirtunjay Kumar Dipak
Keyword(s):  
Claisen Rearrangement ◽  
Diels Alder ◽  
Ring Closing Metathesis ◽  
Design And Synthesis ◽  
Grignard Addition ◽  
Economical Process

Intricate caged molecular frameworks are assembled by an atom economical process via a Diels–Alder (DA) reaction, a Claisen rearrangement, a ring-closing metathesis (RCM) and an alkenyl Grignard addition. The introduction of olefinic moieties in the pentacycloundecane (PCUD) framework at appropriate positions followed by RCM led to the formation of novel heptacyclic cage systems.

Sign in / Sign up

Export Citation Format

Share Document