Self-Assembly of Human Serum Albumin (HSA) andl-α-Dimyristoylphosphatidic Acid (DMPA) Microcapsules for Controlled Drug Release

2004 ◽  
Vol 10 (22) ◽  
pp. 5848-5852 ◽  
Author(s):  
Zhihua An ◽  
Gang Lu ◽  
Helmuth Möhwald ◽  
Junbai Li
Keyword(s):  
Human Serum Albumin ◽  
Drug Release ◽  
Serum Albumin ◽  
Human Serum ◽  
Self Assembly ◽  
Controlled Drug Release ◽  
Dimyristoylphosphatidic Acid

Monitoring the self-assembly of chitosan/glutaraldehyde/cysteamine/Au-colloid and the binding of human serum albumin with hesperidin

Biomaterials ◽  
2004 ◽  
Vol 25 (26) ◽  
pp. 5725-5733 ◽  
Author(s):  
Yingju Liu ◽  
Yanling Li ◽  
Shanchao Liu ◽  
Jia Li ◽  
Shouzhuo Yao
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Self Assembly ◽  
The Self

Paclitaxel-induced formation of 3D nanocrystal superlattices within injectable protein-based hybrid nanoparticles

2018 ◽  
Vol 54 (82) ◽  
pp. 11586-11589
Author(s):  
Jeong Yu Lee ◽  
Ho Yeon Son ◽  
Jae Chul Park ◽  
Jongnam Park ◽  
Yoon Sung Nam
Keyword(s):  
Polyethylene Glycol ◽  
Iron Oxide ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Self Assembly ◽  
Three Dimensional ◽  
Superparamagnetic Iron Oxide ◽  
Hybrid Nanoparticles ◽  
Nanocrystal Superlattices

Self-assembly of monodisperse superparamagnetic iron oxide nanocrystals into a close-packed, three-dimensional (3D) superlattice is designed within cross-linked protein-based nanoparticles composed of human serum albumin and polyethylene glycol.

Microfluidic self-assembly of high cabazitaxel loading albumin nanoparticles

Nanoscale ◽  
2020 ◽  
Vol 12 (32) ◽  
pp. 16928-16933
Author(s):  
Yating Sun ◽  
Robert J. Lee ◽  
Fanchao Meng ◽  
Guiyuan Wang ◽  
Xiaolong Zheng ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Self Assembly ◽  
Promising Method ◽  
Albumin Nanoparticles ◽  
Microfluidic Technology

Microfluidic technology for the preparation of human serum albumin nanoparticles is a promising method.

Self-Assembled N-Succinyl-Chitosan Nanofibers for Reduced Protein Adhesion

2010 ◽  
Vol 76 ◽  
pp. 36-41
Author(s):  
Eyas Dayyoub ◽  
Udo Bakowsky
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Self Assembly ◽  
Adhesion Properties ◽  
Force Microscopy ◽  
Atomic Force ◽  
Biomaterial Surfaces ◽  
Force Curves ◽  
Protein Adhesion

Protein adhesion on biomaterial surfaces plays a major role in determining their biocompatibility and cell responses. The goal of this study was to produce chitosan-based coatings of implant material polyurethane (PUR) for reduced human serum albumin (HSA) adhesion. Succinic anhydride was employed for modifying chitosan and synthesis of N-succinyl-chitosan (NSCS) which was used as a matrix coating of PUR. NSCS showed self-assembly behaviour as nanofiber structures onto PUR surface. Atomic force microscopy (AFM) has emerged as useful tool for the molecular force measurements and therefore it has been chosen to investigate the adhesion properties of Human serum albumin (HSA) on the new matrix coatings and other three implant materials PUR, Silicon and Titanium. HSA molecules were covalently bound to the AFM tip by the use of cyanuric chloride as bivalent linker. Analyzing the force curves demonstrated the antiadhesive properties of the NSCS films in comparison with the uncoated PUR, Silicon and Titanium.

Human Serum Albumin Nanoparticles as a Carrier for On-Demand Sorafenib Delivery

2021 ◽  
Vol 22 ◽  
Author(s):  
Tania Caputo ◽  
Angela Maria Cusano ◽  
Menotti Ruvo ◽  
Anna Aliberti ◽  
Andrea Cusano
Keyword(s):  
Drug Delivery ◽  
Human Serum Albumin ◽  
Drug Release ◽  
Serum Albumin ◽  
Human Serum ◽  
Encapsulation Efficiency ◽  
Kinase Inhibitor ◽  
Force Microscopy ◽  
Atomic Force

Background: Drug delivery systems based on Human Serum Albumin (HSA) have been widely investigated due to their capability to interact with several molecules together with their nontoxicity, non-immunogenicity and biocompatibility. Sorafenib (SOR) is a kinase inhibitor used as the first-line treatment in hepatic cancer. However, because of its several intrinsic drawbacks (low solubility and bioavailability), there is a growing need for discovering new carriers able to overcome the current limitations. Objective: To study HSA particles loaded with SOR as a thermal responsive drug delivery system. Method: A detailed spectroscopy analysis of the HSA and SOR interaction in solution was carried out in order to characterize the temperature dependence of the complex. Based on this study, the synthesis of HSA particles loaded with SOR was optimized. Particles were characterized by Dynamic Light Scattering, Atomic Force Microscopy and by spectrofluorometer. Encapsulation efficiency and in vitro drug release were quantified by RP-HPLC. Results: HSA particles were monodispersed in size (≈ 200 nm); encapsulation efficiency ranged from 25% to 58%. Drug release studies that were performed at 37 °C and 50 °C showed that HS5 particles achieved a drug release of 0.430 µM in 72 hours at 50 °C in PBS buffer, accomplishing a 4.6-fold overall SOR release enhancement following a temperature increase from 37 °C to 50 °C. Conclusion: The system herein presented has the potential to exert a therapeutic action (in the nM range) triggering a sustained temperature-controllable release of relevant drugs.

Adsorption of obidoxime onto human serum albumin nanoparticles: Drug loading, particle size and drug release

2010 ◽  
Vol 27 (6) ◽  
pp. 506-513 ◽  
Author(s):  
Jürgen Kufleitner ◽  
Sylvia Wagner ◽  
Franz Worek ◽  
Hagen von Briesen ◽  
Jörg Kreuter
Keyword(s):  
Particle Size ◽  
Human Serum Albumin ◽  
Drug Release ◽  
Serum Albumin ◽  
Human Serum ◽  
Drug Loading ◽  
Albumin Nanoparticles

Multifunctional human serum albumin-therapeutic nucleotide conjugate with redox and pH-sensitive drug release mechanism for cancer theranostics

2017 ◽  
Vol 27 (16) ◽  
pp. 3925-3930 ◽  
Author(s):  
Vladimir A. Lisitskiy ◽  
Hamda Khan ◽  
Tatyana V. Popova ◽  
Alexey S. Chubarov ◽  
Olga D. Zakharova ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Drug Release ◽  
Serum Albumin ◽  
Human Serum ◽  
Ph Sensitive ◽  
Release Mechanism ◽  
Drug Release Mechanism ◽  
Cancer Theranostics

Structural insights into pH-responsive drug release of self-assembling human serum albumin-silk fibroin nanocapsules

2018 ◽  
Vol 133 ◽  
pp. 176-187 ◽  
Author(s):  
Claudia Tallian ◽  
Alexandra Herrero-Rollett ◽  
Karina Stadler ◽  
Robert Vielnascher ◽  
Karin Wieland ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Drug Release ◽  
Serum Albumin ◽  
Human Serum ◽  
Silk Fibroin ◽  
Ph Responsive ◽  
Self Assembling ◽  
Structural Insights
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