scholarly journals Caenorhabditis elegans—Applications to Nematode Genomics

2003 ◽  
Vol 4 (2) ◽  
pp. 194-202 ◽  
Author(s):  
William F. Gregory ◽  
John Parkinson
Keyword(s):  
Caenorhabditis Elegans ◽  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Model Organism ◽  
Free Living ◽  
Free Living Nematode

The complete genome sequence of the free-living nematodeCaenorhabditis eleganswas published 4 years ago. Since then, we have seen great strides in technologies that seek to exploit this data. Here we describe the application of some of these techniques and other advances that are helping us to understand about not only the biology of this important model organism but also the entire phylum Nematoda.

scholarly journals Complete Genome Sequence of the Arcobacter halophilus Type Strain CCUG 53805

2018 ◽  
Vol 7 (14) ◽  
Author(s):  
William G. Miller ◽  
Emma Yee ◽  
James L. Bono
Keyword(s):  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Type Strain ◽  
Marine Environments ◽  
Free Living ◽  
Content Type

Many Arcobacter spp. are free living and are routinely recovered from marine environments.

scholarly journals Complete Genome Sequence of GD1108, a Moderate-Virulence Strain of Human-Associated ST398 Methicillin-Susceptible Staphylococcus aureus

2019 ◽  
Vol 8 (28) ◽  
Author(s):  
Jo-Ann McClure ◽  
Steven M. Shideler ◽  
Kunyan Zhang
Keyword(s):  
Staphylococcus Aureus ◽  
Caenorhabditis Elegans ◽  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Sequence Type ◽  
Infection Model ◽  
Content Type ◽  
Severe Infections

Staphylococcus aureus multilocus sequence type 398 (ST398) is responsible for an increasing number of severe infections in humans. There are no reports detailing if all ST398 strains are equally virulent. We present the genome sequence of the moderate-virulence ST398 methicillin-susceptible Staphylococcus aureus strain GD1108, determined in a Caenorhabditis elegans infection model, to reveal the ST398 sublineage virulence.

scholarly journals Free-Living EnterobacteriumPragia fontium24613: Complete Genome Sequence and Metabolic Profiling

2017 ◽  
Vol 13 ◽  
pp. 117693431770086 ◽  
Author(s):  
Kateřina Snopková ◽  
Karel Sedlář ◽  
Juraj Bosák ◽  
Eva Chaloupková ◽  
Ivo Sedláček ◽  
...  
Keyword(s):  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Metabolic Profiling ◽  
Complete Genome ◽  
Free Living

scholarly journals Complete Genome Sequence of aGluconacetobacter hanseniiATCC 23769 Isolate, AY201, Producer of Bacterial Cellulose and Important Model Organism for the Study of Cellulose Biosynthesis

2016 ◽  
Vol 4 (4) ◽  
Author(s):  
Sarah Pfeffer ◽  
Kalpa Mehta ◽  
R. Malcolm Brown
Keyword(s):  
Nucleotide Sequence ◽  
Bacterial Cellulose ◽  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Complete Nucleotide Sequence ◽  
Complete Genome ◽  
Model Organism ◽  
Cellulose Biosynthesis ◽  
Gluconacetobacter Hansenii

The cellulose producer and model organism used for the study of cellulose biosynthesis,Gluconacetobacter hanseniiAY201, is a variant ofG. hanseniiATCC 23769. We report here the complete nucleotide sequence ofG. hanseniiAY201, information which may be utilized to further the research into understanding the genes necessary for cellulose biosynthesis.

scholarly journals Caenorhabditis elegans Infrared-Based Motility Assay Identified New Hits for Nematicide Drug Development

2019 ◽  
Vol 6 (1) ◽  
pp. 29 ◽  
Author(s):  
Gastón Risi ◽  
Elena Aguilera ◽  
Enrique Ladós ◽  
Gonzalo Suárez ◽  
Inés Carrera ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Model Organism ◽  
Proof Of Concept ◽  
Free Living ◽  
C Elegans ◽  
Nematode Parasites ◽  
Automated Assay ◽  
Free Living Nematode ◽  
Vertebrate Model ◽  
Electronegative Atom

Nematode parasites have a profound impact on humankind, infecting nearly one-quarter of the world’s population, as well as livestock. There is a pressing need for discovering nematicides due to the spread of resistance to currently used drugs. The free-living nematode Caenorhabditis elegans is a formidable experimentally tractable model organism that offers key advantages in accelerating nematicide discovery. We report the screening of drug-like libraries using an overnight high-throughput C. elegans assay, based on an automated infrared motility reader. As a proof of concept, we screened the “Pathogen Box” library, and identical results to a previous screen using Haemonchus contortus were obtained. We then screened an in-house library containing a diversity of compound families. Most active compounds had a conjugation of an unsaturation with an electronegative atom (N, O, or S) and an aromatic ring. Importantly, we identified symmetric arylidene ketones and aryl hydrazine derivatives as novel nematicides. Furthermore, one of these compounds, (1E,2E)-1,2-bis(thiophen-3-ylmethylene)hydrazine, was active as a nematicide at 25 µm, but innocuous to the vertebrate model zebrafish at 50 µm. Our results identified novel nematicidal scaffolds and illustrate the value of C. elegans in accelerating nematicide discovery using a nonlabor-intensive automated assay that provides a simple overnight readout.

scholarly journals Complete Genome Sequence of Torque teno indri virus 1, a Novel Anellovirus in Blood from a Free-Living Lemur

2017 ◽  
Vol 5 (30) ◽  
Author(s):  
Rina Amatya ◽  
Sharon L. Deem ◽  
Ingrid J. Porton ◽  
David Wang ◽  
Efrem S. Lim
Keyword(s):  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
New Genus ◽  
Sequence Analyses ◽  
Free Living ◽  
Indri Indri ◽  
Putative Member ◽  
Torque Teno Sus Virus

ABSTRACT We identified Torque teno indri virus 1 (TTIV1), the first anellovirus in a free-living lemur (Indri indri). The complete circular 2,572-nucleotide (nt) TTIV1 genome is distantly related to torque teno sus virus. Phylogenetic and sequence analyses support TTIV1 as a putative member of a new genus within the Anelloviridae family.

scholarly journals Complete Genome Sequence of a Multidrug-Resistant Strain, Escherichia coli ATCC BAA-196, as a Model for Studying Induced Antibiotic Resistance Reversion

2019 ◽  
Vol 8 (50) ◽  
Author(s):  
Ilya S. Korotetskiy ◽  
Monique Joubert ◽  
Setshaba Taukobong ◽  
Ardak B. Jumagaziyeva ◽  
Sergey V. Shilov ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Model Organism ◽  
Multidrug Resistant ◽  
Negative Control ◽  
Strain Atcc ◽  
Content Type ◽  
Multidrug Resistant Strain

Here, we report the complete genome sequence of the multidrug-resistant Escherichia coli strain ATCC BAA-196, a model organism used for studying possible antibiotic resistance reversion induced by FS-1, an iodine-containing complex. Two genomes, representing FS-1-treated and negative-control variants and composed of a chromosome and several plasmids, were assembled.

scholarly journals Caenorhabditis elegans: nature and nurture gift to nematode parasitologists

Parasitology ◽  
2017 ◽  
Vol 145 (8) ◽  
pp. 979-987 ◽  
Author(s):  
Gustavo Salinas ◽  
Gastón Risi
Keyword(s):  
Animal Model ◽  
Caenorhabditis Elegans ◽  
Parasitic Nematode ◽  
Model Organism ◽  
Parasitic Nematodes ◽  
Free Living ◽  
C Elegans ◽  
Free Living Nematode ◽  
Basic Biology ◽  
Nature And Nurture

AbstractThe free-living nematode Caenorhabditis elegans is the simplest animal model organism to work with. Substantial knowledge and tools have accumulated over 50 years of C. elegans research. The use of C. elegans relating to parasitic nematodes from a basic biology standpoint or an applied perspective has increased in recent years. The wealth of information gained on the model organism, the use of the powerful approaches and technologies that have advanced C. elegans research to parasitic nematodes and the enormous success of the omics fields have contributed to bridge the divide between C. elegans and parasite nematode researchers. We review key fields, such as genomics, drug discovery and genetics, where C. elegans and nematode parasite research have convened. We advocate the use of C. elegans as a model to study helminth metabolism, a neglected area ready to advance. How emerging technologies being used in C. elegans can pave the way for parasitic nematode research is discussed.

scholarly journals Complete Genome Sequence of the Photoautotrophic and Bacteriochlorophyll e-Synthesizing Green Sulfur Bacterium Chlorobaculum limnaeum DSM 1677T

2017 ◽  
Vol 5 (24) ◽  
Author(s):  
Marcus Tank ◽  
Zhenfeng Liu ◽  
Niels-Ulrik Frigaard ◽  
Lynn P. Tomsho ◽  
Stephan C. Schuster ◽  
...  
Keyword(s):  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Sulfur Metabolism ◽  
Model Organism ◽  
Green Sulfur Bacterium ◽  
Content Type ◽  
Green Sulfur ◽  
Bacteriochlorophyll E ◽  
Bacteriochlorophyll Biosynthesis

ABSTRACT Chlorobaculum limnaeum DSM 1677T is a mesophilic, brown-colored, chlorophototrophic green sulfur bacterium that produces bacteriochlorophyll e and the carotenoid isorenieratene as major pigments. This bacterium serves as a model organism in molecular research on photosynthesis, sulfur metabolism, and bacteriochlorophyll biosynthesis. We report here the complete genome sequence.

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