scholarly journals Bilinear modeling of batch processes. Part III: parameter stability

2013 ◽  
Vol 28 (1) ◽  
pp. 10-27 ◽  
Author(s):  
Jose Maria González-Martínez ◽  
Jose Camacho ◽  
Alberto Ferrer
Keyword(s):  
Batch Processes ◽  
Parameter Stability ◽  
Bilinear Modeling

Room Temperature Flow Electrochemistry as a Means of Retaining the “Memory of Chirality” via Hofer Moest Type Reaction

2020 ◽  
Author(s):  
Tomas Hardwick ◽  
Rossana Cicala ◽  
Nisar Ahmed
Keyword(s):  
Continuous Flow ◽  
Room Temperature ◽  
Biological Activities ◽  
Supporting Electrolyte ◽  
Enantiomeric Excess ◽  
Flow Chemistry ◽  
Batch Processes ◽  
Enabling Technology ◽  
Chiral Compounds ◽  
Memory Of Chirality

<p>Many chiral compounds have become of great interest to the pharmaceutical industry as they possess various biological activities. Concurrently, the concept of “memory of chirality” has been proven as a powerful tool in asymmetric synthesis, while flow chemistry has begun its rise as a new enabling technology to add to the ever increasing arsenal of techniques available to the modern day chemist. Here, we have employed a new simple electrochemical microreactor design to oxidise an L-proline derivative at room temperature in continuous flow. Flow performed in microreactors offers up a number of benefits allowing reactions to be performed in a more convenient and safer manner, and even allow electrochemical reactions to take place without a supporting electrolyte due to a very short interelectrode distance. By the comparison of electrochemical oxidations in batch and flow we have found that continuous flow is able to outperform its batch counterpart, producing a good yield (71%) and a better enantiomeric excess (64%) than batch with a 98% conversion. We have, therefore, provided evidence that continuous flow chemistry has the potential to act as a new enabling technology to replace some aspects of conventional batch processes. </p>

Research on Multistage-based MPCA Modeling and Monitoring Method for Batch Processes

2010 ◽  
Vol 36 (9) ◽  
pp. 1312-1320 ◽  
Author(s):  
Yu-Qing CHANG ◽  
Shu WANG ◽  
Shuai TAN ◽  
Fu-Li WANG ◽  
Jie YANG
Keyword(s):  
Batch Processes ◽  
Monitoring Method
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