Solving matrix effect, spectral overlapping and nonlinearity by generalized standard addition method coupled with radial basis functions-partial least squares: simultaneous determination of atorvastatin and amlodipine in urine

2013 ◽  
Vol 27 (3-4) ◽  
pp. 63-69
Author(s):  
Masoud Shariati-Rad ◽  
Mohsen Irandoust ◽  
Tayyebeh Amini ◽  
Mojtaba Shamsipur
Keyword(s):  
Least Squares ◽  
Simultaneous Determination ◽  
Partial Least Squares ◽  
Radial Basis Functions ◽  
Matrix Effect ◽  
Standard Addition ◽  
Basis Functions ◽  
Standard Addition Method ◽  
Addition Method

Determination of Vitamin and Aminophylline by a Method of PLS

2014 ◽  
Vol 881-883 ◽  
pp. 493-496
Author(s):  
Yan Hong Lei
Keyword(s):  
Vitamin C ◽  
Least Squares ◽  
Simultaneous Determination ◽  
Partial Least Squares ◽  
Spectrophotometric Method ◽  
Standard Addition ◽  
Standard Addition Method ◽  
Addition Method ◽  
Pls Method

This paper described a spectrophotometric method for simultaneous determination of two drugs,Vitamin C, aminophylline with the aid of partial least squares. The proposed method was successfully applied to overcome the overlapping of their absorption curves in the UV spectral region.The result was shown that the predictive errors obtained by the PLS method was 9.25%. Recovery of the method by standard addition method was respectively valued 92.43% (for vitamin C) and 102.53% (for aminophylline).

Simultaneous spectrophotometric determination of minoxidil and tretinoin by the H-point standard addition method and partial least squares

2009 ◽  
Vol 63 (3) ◽  
Author(s):  
Maryam Bordbar ◽  
Ali Yeganeh-Faal ◽  
Jahanbakhsh Ghasemi ◽  
Mohammad Ahari-Mostafavi ◽  
Nahid Sarlak ◽  
...  
Keyword(s):  
Least Squares ◽  
Partial Least Squares ◽  
Standard Addition ◽  
Partial Least Square ◽  
Least Square ◽  
Standard Addition Method ◽  
Relative Standard Error ◽  
Addition Method ◽  
Relative Standard

AbstractA simple, sensitive and selective spectrophotometric method for simultaneous determination of tretinoin and minoxidil using partial least square (PLS) calibration and H-point standard addition method (HPSAM) is described. The results of the H-point standard addition method show that minoxidil and tretinoin can be determined simultaneously with the concentration ratio of tretinoin to minoxidil varying from 2: 1 to 1: 33 in mixed samples. A partial least squares multivariate calibration method for the analysis of binary mixtures of tretinoin and minoxidil was also developed. The total relative standard error for applying the PLS method to eleven synthetic samples in the concentration range of 0–10 μg mL−1 tretinoin and 0–32 μg mL−1 minoxidil was 2.59 %. Both proposed methods (PLS and HPSAM) were also successfully applied in the determination of tretinoin and minoxidil in several synthetic pharmaceutical solutions.

scholarly journals Simultaneous spectrophotometric determination of valsartan and hydrochlorothiazide by H-point standard addition method and partial least squares regression

2011 ◽  
Vol 61 (1) ◽  
pp. 37-50 ◽  
Author(s):  
Karunanidhi Lakshmi ◽  
Sivasubramanian Lakshmi
Keyword(s):  
Least Squares ◽  
Partial Least Squares ◽  
Spectrophotometric Determination ◽  
Partial Least Squares Regression ◽  
Standard Addition ◽  
Standard Addition Method ◽  
Calibration Model ◽  
Least Squares Regression ◽  
Addition Method

Simultaneous spectrophotometric determination of valsartan and hydrochlorothiazide by H-point standard addition method and partial least squares regression Simultaneous determination of valsartan and hydrochlorothiazide by the H-point standard additions method (HPSAM) and partial least squares (PLS) calibration is described. Absorbances at a pair of wavelengths, 216 and 228 nm, were monitored with the addition of standard solutions of valsartan. Results of applying HPSAM showed that valsartan and hydrochlorothiazide can be determined simultaneously at concentration ratios varying from 20:1 to 1:15 in a mixed sample. The proposed PLS method does not require chemical separation and spectral graphical procedures for quantitative resolution of mixtures containing the titled compounds. The calibration model was based on absorption spectra in the 200-350 nm range for 25 different mixtures of valsartan and hydrochlorothiazide. Calibration matrices contained 0.5-3 μg mL-1 of both valsartan and hydrochlorothiazide. The standard error of prediction (SEP) for valsartan and hydrochlorothiazide was 0.020 and 0.038 μg mL-1, respectively. Both proposed methods were successfully applied to the determination of valsartan and hydrochlorothiazide in several synthetic and real matrix samples.

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