Insights into the Distance Dependence of Electron Transfer through Conformationally Constrained Peptides

2020 ◽  
Vol 7 (5) ◽  
pp. 1225-1237
Author(s):  
Claudio Zuliani ◽  
Fernando Formaggio ◽  
Laura Scipionato ◽  
Claudio Toniolo ◽  
Sabrina Antonello ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Conformationally Constrained ◽  
Distance Dependence ◽  
Constrained Peptides

scholarly journals Small and Simple, yet Sturdy: Conformationally Constrained Peptides with Remarkable Properties

2021 ◽  
Vol 22 (4) ◽  
pp. 1611
Author(s):  
Krištof Bozovičar ◽  
Tomaž Bratkovič
Keyword(s):  
Chemical Space ◽  
Structure Optimization ◽  
Peptide Chain ◽  
Conformationally Constrained ◽  
Drug Candidates ◽  
Conformational Constraints ◽  
Macrocyclic Peptides ◽  
Constrained Peptides ◽  
Sheer Size

The sheer size and vast chemical space (i.e., diverse repertoire and spatial distribution of functional groups) underlie peptides’ ability to engage in specific interactions with targets of various structures. However, the inherent flexibility of the peptide chain negatively affects binding affinity and metabolic stability, thereby severely limiting the use of peptides as medicines. Imposing conformational constraints to the peptide chain offers to solve these problems but typically requires laborious structure optimization. Alternatively, libraries of constrained peptides with randomized modules can be screened for specific functions. Here, we present the properties of conformationally constrained peptides and review rigidification chemistries/strategies, as well as synthetic and enzymatic methods of producing macrocyclic peptides. Furthermore, we discuss the in vitro molecular evolution methods for the development of constrained peptides with pre-defined functions. Finally, we briefly present applications of selected constrained peptides to illustrate their exceptional properties as drug candidates, molecular recognition probes, and minimalist catalysts.

Electron transfer through RNA: Chemical probing of dual distance dependence

2011 ◽  
Vol 19 (22) ◽  
pp. 6881-6884 ◽  
Author(s):  
Tadao Takada ◽  
Yumiko Otsuka ◽  
Mitsunobu Nakamura ◽  
Kazushige Yamana
Keyword(s):  
Electron Transfer ◽  
Chemical Probing ◽  
Dual Distance ◽  
Distance Dependence

Four Aspects of the Distance Dependence of Electron-Transfer Rates

1982 ◽  
pp. 213-233 ◽  
Author(s):  
EPHRAIM BUHKS ◽  
RALPH G. WILKINS ◽  
STEPHAN S. ISIED ◽  
JOHN F. ENDICOTT
Keyword(s):  
Electron Transfer ◽  
Transfer Rates ◽  
Distance Dependence

scholarly journals Theoretical Study of Shallow Distance Dependence of Proton-Coupled Electron Transfer in Oligoproline Peptides

2020 ◽  
Vol 142 (32) ◽  
pp. 13795-13804
Author(s):  
Pengfei Li ◽  
Alexander V. Soudackov ◽  
Brian Koronkiewicz ◽  
James M. Mayer ◽  
Sharon Hammes-Schiffer
Keyword(s):  
Electron Transfer ◽  
Theoretical Study ◽  
Proton Coupled Electron Transfer ◽  
Distance Dependence

Dissociative Attachment as a Probe of the Distance Dependence of Intramolecular Electron Transfer

1995 ◽  
Vol 99 (33) ◽  
pp. 12379-12381 ◽  
Author(s):  
D. M. Pearl ◽  
P. D. Burrow ◽  
J. J. Nash ◽  
H. Morrison ◽  
D. Nachtigallova ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Intramolecular Electron Transfer ◽  
Dissociative Attachment ◽  
Distance Dependence
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