Thiamine Diphosphate Dependent KdcA‐Catalysed Formyl Elongation of Aldehydes

ChemCatChem ◽  
2019 ◽  
Vol 11 (17) ◽  
pp. 4276-4280 ◽  
Author(s):  
Philipp Germer ◽  
Ekaterina Gauchenova ◽  
Lydia Walter ◽  
Michael Müller
Keyword(s):  
Thiamine Diphosphate

scholarly journals Two Marine Desulfotomaculum spp. of Different Origin are Capable of Utilizing Acetone and Higher Ketones

2021 ◽  
Author(s):  
Jasmin Frey ◽  
Sophie Kaßner ◽  
Bernhard Schink
Keyword(s):  
Sulfate Reducing Bacteria ◽  
Thiamine Diphosphate ◽  
Sulfate Reducers ◽  
Sulfate Reducing ◽  
Reducing Bacteria ◽  
Nitrate Reducing Bacteria ◽  
Different Origin

AbstractDegradation of acetone and higher ketones has been described in detail for aerobic and nitrate-reducing bacteria. Among sulfate-reducing bacteria, degradation of acetone and other ketones is still an uncommon ability and has not been understood completely yet. In the present work, we show that Desulfotomaculum arcticum and Desulfotomaculum geothermicum are able to degrade acetone and butanone. Total proteomics of cell-free extracts of both organisms indicated an involvement of a thiamine diphosphate-dependent enzyme, a B12-dependent mutase, and a specific dehydrogenase during acetone degradation. Similar enzymes were recently described to be involved in acetone degradation by Desulfococcus biacutus. As there are so far only two described sulfate reducers able to degrade acetone, D. arcticum and D. geothermicum represent two further species with this capacity. All these bacteria appear to degrade acetone via the same set of enzymes and therefore via the same pathway.

scholarly journals Thiamine Diphosphate Status and Dialysis-Related Losses in End-Stage Kidney Disease Patients Treated with Hemodialysis

2017 ◽  
Vol 44 (4) ◽  
pp. 294-300 ◽  
Author(s):  
Magdalena Jankowska ◽  
Paweł Rudnicki-Velasquez ◽  
Hanna Storoniak ◽  
Przemysław Rutkowski ◽  
Bolesław Rutkowski ◽  
...  
Keyword(s):  
Body Weight ◽  
Kidney Disease ◽  
Dietary Intake ◽  
Whole Blood ◽  
Vitamin B1 ◽  
Thiamine Diphosphate ◽  
End Stage Kidney Disease ◽  
Before And After ◽  
End Stage ◽  
The Impact

Aim: (1) To describe the whole blood content of thiamine diphosphate (TDP), a biologically active form of vitamin B1 in end-stage kidney disease patients treated with hemodialysis (HD); (2) to establish the impact of a single HD procedure on TDP blood concentrations; and (3) to describe potential explanatory variables influencing TDP dialysis related losses, including dialysis prescription, vitamin B1 dietary intake and supplementation. Methods: Single-center, cross-sectional study in 50 clinically stable maintenance HD patients. The assessment of whole blood TDP with the High Performance Liquid Chromatography method, before and after a single, middle-week dialysis session and analysis of clinical and laboratory parameters potentially influencing TDP status Results: We report a significant difference in TDP levels before and after HD sessions - 42.5 (95% CI 38.7-46.2) μg/L and 23.6 (95% CI 18.9-28.2) μg/L, respectively (p = 0.000). The magnitude of intradialytic TDP changes is highly variable among individuals and is negatively associated only with the body weight of the patients (p < 0.013). Vitamin B1 dietary intake and supplementation do not influence whole blood TDP and dialysis-related loss of TDP. Conclusions: TDP, a bioactive compound of vitamin B1, is substantially lost during the HD procedure, and the magnitude of its loss is associated with the patient's body weight but it is not influenced by vitamin B1 dietary intake and standard supplementation dose.

scholarly journals Molecular Mechanism of Allosteric Substrate Activation in a Thiamine Diphosphate-dependent Decarboxylase

2007 ◽  
Vol 282 (48) ◽  
pp. 35269-35278 ◽  
Author(s):  
Wim Versées ◽  
Stijn Spaepen ◽  
Martin D. H. Wood ◽  
Finian J. Leeper ◽  
Jos Vanderleyden ◽  
...  
Keyword(s):  
Molecular Mechanism ◽  
Thiamine Diphosphate ◽  
Substrate Activation

Thiamine-diphosphate kinase

1997 ◽  
pp. 397-400
Author(s):  
Dietmar Schomburg ◽  
Dörte Stephan
Keyword(s):  
Thiamine Diphosphate

scholarly journals Synergistic effect of cytochrome C, flavin mononucleotide and thiamine diphosphate in injured states of heart and cerebral vessels

1981 ◽  
Vol 31 ◽  
pp. 195
Author(s):  
Ryuta Ito ◽  
Hiroshi Henomatsu ◽  
Hironori Kimura ◽  
Jun Katagiri ◽  
Terumichi Kuninaka ◽  
...  
Keyword(s):  
Cytochrome C ◽  
Synergistic Effect ◽  
Cerebral Vessels ◽  
Flavin Mononucleotide ◽  
Thiamine Diphosphate

Étude de l'interaction de la thiamine diphosphate avec l'ion magnésium

Biochimie ◽  
1980 ◽  
Vol 61 (11-12) ◽  
pp. 1301-1308 ◽  
Author(s):  
Anne-Marie Chauvet-Monges ◽  
Jean-Pierre Monti ◽  
Aimé Crevat ◽  
Emile Jean Vincent
Keyword(s):  
Thiamine Diphosphate
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