scholarly journals Primary melanoma in the bronchus

2021 ◽  
Vol 9 (12) ◽  
Author(s):  
Akina Nigi ◽  
Hirokazu Toyoshima ◽  
Shigeto Kondo ◽  
Motoaki Tanigawa
Keyword(s):  
Primary Melanoma

PRIMARY MELANOMA OF THE GALLBLADDER MANIFESTED BY ACUTE CHOLECYSTITIS. DESCRIPTION OF A SINGLE CASE

2018 ◽  
Vol 64 (2) ◽  
pp. 253-255
Author(s):  
Oleg Kit ◽  
Yevgeniy Kolesnikov ◽  
Roman Myagkov ◽  
Leonid Kharin ◽  
Yevgeniya Nepomnyashchaya
Keyword(s):  
Acute Cholecystitis ◽  
Mucous Membrane ◽  
Cutaneous Melanoma ◽  
Multidisciplinary Approach ◽  
Single Case ◽  
Primary Melanoma ◽  
Metastatic Lesions ◽  
Long Term Follow Up

Most of melanomas of the gallbladder are metastatic lesions of cutaneous melanoma. Primary melanomas of the gallbladder are described as single, polypoid, intraluminal masses emanating from the mucous membrane. The most important characteristic is the absence of melanoma damage to the skin. If it is not possible to localize primary melanoma a multidisciplinary approach to diagnostic search comes to the fore. Predicting for primary melanoma of the gallbladder is a difficult task due to the small number of cases and the absence of long-term follow-up for this category of patients.

Molecular analysis of primary melanoma T cells identifies patients at risk for metastatic recurrence

immuneACCESS ◽  
2020 ◽  
Author(s):  
W Pruessmann ◽  
J Rytlewski ◽  
J Wilmott ◽  
MC Mihm Jr ◽  
GH Attrill ◽  
...  
Keyword(s):  
At Risk ◽  
T Cells ◽  
Molecular Analysis ◽  
Primary Melanoma ◽  
Metastatic Recurrence ◽  
Patients At Risk

scholarly journals Pan-cancer analysis of CD274 (PD-L1) mutations in 314,631 patient samples and subset correlation with PD-L1 protein expression

2021 ◽  
Vol 9 (6) ◽  
pp. e002558
Author(s):  
Richard S.P. Huang ◽  
Brennan Decker ◽  
Karthikeyan Murugesan ◽  
Matthew Hiemenz ◽  
Douglas A. Mata ◽  
...  
Keyword(s):  
Protein Expression ◽  
Checkpoint Inhibitors ◽  
Endometrial Adenocarcinoma ◽  
Primary Melanoma ◽  
B Cell Lymphoma ◽  
Unknown Primary ◽  
Future Research ◽  
Tumor Type ◽  
Missense Mutations ◽  
L1 Protein

BackgroundThe effects of non-amplification short variant (SV) mutations in CD274 (programmed death-ligand 1 (PD-L1)) on PD-L1 protein expression and immune checkpoint inhibitors (ICPIs) therapy are unknown. Here, we present a retrospective analysis of CD274 mutations detected by comprehensive genomic profiling (CGP) and correlate these results with tumor-cell PD-L1 immunohistochemistry (IHC)-based expression assessment to better understand the relationship between mutations and protein expression of PD-L1.MethodsCGP was performed on hybridization-captured, adaptor ligation-based libraries using DNA and/or RNA extracted from 314,631 tumor samples that were sequenced for up to 406 cancer-related genes and select gene rearrangements. PD-L1 IHC was performed on a subset of cases (n=58,341) using the DAKO 22C3 PD-L1 IHC assay and scored with the tumor proportion score (TPS).ResultsOverall, the prevalence of CD274 SV mutations was low (0.3%, 1081/314,631) with 577 unique variants. The most common CD274 SV mutations were R260H (n=51), R260C (n=18), R125Q (n=12), C272fs*13 (n=11), R86W (n=10), and R113H (n=10). The prevalence of CD274 mutations varied depending on tumor type with diffuse large B-cell lymphoma (1.9%, 19/997), cutaneous squamous cell carcinoma (1.6%, 14/868), endometrial adenocarcinoma (1.0%, 36/3740), unknown primary melanoma (0.9%, 33/3679), and cutaneous melanoma (0.8%, 32/3874) having the highest frequency of mutations. Of the R260H cases concurrently tested with PD-L1 IHC, most (81.8%, 9/11) had no PD-L1 expression, which contrasts to the five E237K cases where most (80%, 4/5) had PD-L1 expression. In addition, we saw a significantly lower level of PD-L1 expression in samples with a clonal truncating variant (nonsense or frameshift indel) when compared with samples with a subclonal truncating variants (mean: TPS=1 vs TPS=38; p<0.001), and also in clonal versus subclonal missense mutations (mean: TPS=11 vs TPS=22, respectively; p=0.049)ConclusionsWe defined the landscape of CD274 mutations in a large cohort of tumor types that can be used as a reference for examining CD274 mutations as potential resistance biomarkers for ICPI. Furthermore, we presented novel data on the correlation of CD274 mutations and PD-L1 protein expression, providing important new information on the potential functionality of these mutations and can serve as a basis for future research.

Primary Melanoma of the Lung

2006 ◽  
pp. 293-297 ◽  
Author(s):  
Richard A. Scolyer ◽  
James F. Bishop ◽  
John F. Thompson
Keyword(s):  
Primary Melanoma

Primary Melanoma of the Uterine Cervix After Supracervical Hysterectomy

2007 ◽  
Vol 51 (1) ◽  
pp. 86-88 ◽  
Author(s):  
Bo Jin ◽  
Alan Goldsmith ◽  
Harish Budev ◽  
Mousa Al-Abbadi
Keyword(s):  
Uterine Cervix ◽  
Primary Melanoma ◽  
Supracervical Hysterectomy

scholarly journals Polyclonality of BRAF mutations in primary melanoma and the selection of mutant alleles during progression

2011 ◽  
Vol 104 (3) ◽  
pp. 464-468 ◽  
Author(s):  
J Lin ◽  
Y Goto ◽  
H Murata ◽  
K Sakaizawa ◽  
A Uchiyama ◽  
...  
Keyword(s):  
Primary Melanoma ◽  
Braf Mutations ◽  
Selection Of
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